Myeloid Disorders Flashcards

1
Q

Translocation in CML

A

9, 22

Philadelphia Chr

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2
Q

Four classic substypes of myeloproliferative disorders

A

Polycythemia Vera
Essential Thrombocytosis
Chronic Myelogenous Leukemia
Agnogenic Myeloid Metaplasia (Myeloid Fibrosis)

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3
Q

Philadelphia chromosome turns on ____

A

BCR-ABL gene

Tyrosine Kinase

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4
Q

Three physical exam findings that support a diagnosis of physical diagnsois

A

splenomegaly
ecchymoses
early satiety

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5
Q

Laboratory findings of CML

A

Elevated WBC with all granulocyte precursors in the peripheral blood
More RBC, platelets, eosinophils, and basophils

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6
Q

Polycythemia vera is associated with a ______ mutation

A

Jak2

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7
Q

What should be elevated to diagnose CLL?

A

ABSOLUTE LYMPHOCYTE NUMBER

NOT PERCENTAGE

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8
Q

Translocation favorable in AML? unfavorable?

A

FAVORABLE – 15, 17

Unfavorable – 9, 22 or multiple chromosomal defects

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9
Q

Acute Promyelocytic Leukemia is characterized by the _____ mutation

A

15, 17

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10
Q

Classic example of a drug that causes aplastic

A

Chloramphenicol

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11
Q

Paroxysmal nocturnal hemoglobinuria is associatd with an acquired mutation of…

A

PIG-A gene

Decreases CD55 and CD59

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