Myocardial and Pericardial Disease Flashcards
cardiomyopathy
priamry disorder that is not a disease of other cardia structures (ie mi, htn, valve stenosis)
Primary cardiomyopathies
- Dilated (congestive)
- Hypertrophic
- Restrictive/constrictive
Hypertrophic Cardiomyopathy
Hypertrophy w/o dilation of LV Myofiber disarray endocardial and interstitial fibrosis Impaired diastolic fxn Assymetrical septal hypertrophy systolic anterior motion of mitral valve leaflet
Restrictive vs constrictive disease
constrictive is pericardial, restrictive is infiltrative
Familial HCM
Autosomal Dominant
Most common cause of sudden death in athletes
many mutations
effect of isotonic exercise on heart
mass-volume ratio unchanged
isometric exercise effect on heart
mass-volume ration increases
resolves w/in weeks of discontinuing exertion
Most common causes of Sudden cardiac death (SCD)
- coronary atherosclerosis
2. cardiomyopathies
diltiazem
prevents cardiomyopathy in mouse
Idiopathic Dilated Cardiomyopathy
unknown etiology
LV dilation, normal wall thickness
Dilated Cardiomyopathy genetics
20-30% familial occurrence
Hallmark of restrictive cardiomyopathies
abnormal diastolic fxn (in addition to hypertrophic) , heart failure R>L, in HCM and DMC L>R
restrictive cardiomyopathy
infiltration of things which cause wall to become less compliance
cardiac amyloidosis
interstitial depostion of eosinophils
agglutination of myocytes
sarcoidosis
non caseating granulomas,
cause conduction and valve abnormalities