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Flashcards in Myometrial Lesions And Tumors Deck (13)
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1
Q

What are the two tumors of the myometrium? Which one is benign and which one is most malignant?

A

Leiomyoma (benign) and leiomyosarcoma (malignant)

2
Q

Leiomyoma is the most common what?

A

Most common tumor in females

3
Q

What are three genes implicated in leiomyoma?

A

HMGIC, HMGIY, and MED12

4
Q

The tumor is related to what as far as cause?

A

Estrogen exposure

5
Q

What is gross examination of leiomyoma?

A

Multiple, white whorled masses

6
Q

Typical patient presenting with leiomyoma?

A

Pre menopausal

7
Q

Talk about the progression of symptoms for leiomyoma?

A

Asymptomatic usually, but if there are symptoms they are AUB, infertility and pelvic mass

8
Q

How do leiomyosarcomas arise?

A

De novo

9
Q

Typical presenting patient with the sarcoma?

A

Post menopausal women

10
Q

Gross examination of sarcoma?

A

Single lesion with necrosis and hemorrhage

11
Q

3 histo features of sarcoma?

A

High mitotic cavity, nuclear atypia, and necrosis

12
Q

What is the most common site of metastasis for sarcoma?

A

Lung

13
Q

Why is lung a common site?

A

Spreads up the uterine vein, back to the heart, and to the lungs.