N+V Flashcards
(14 cards)
Nausea in 1st trimester
Self care
If V is severe use short term antihistamine such as promethazine, prochlorperazine, ondaesteron or chlorpromethazine
Hyperemesis gravidarum
Serious condition requiring regular antiemetic therapy, IV fluids and electrolyte replacement. Consider thiamine supplementation to reduce risk of wenicke encepathopathy
Post- Op N+V when to use combination
Combination of 2 antiemetics with different MOA if at high risk
Common prophylactic anti-emetics for post op
5HT3 receptor antagonist (droperidol, dex)
Phenothiazines (prochloperazine)
Antihistamines (cyclizine)
Which anti-emetic is used in palliative care for the relief of nausea and vomiting
Levopromazine
What anti-emetic is used for the management of chemotherapy induced N+V
Dexamethasone
Metoclopramide MHRA
Risk of EPSE
Use for maximum of 5 days
Anti dopamine anti-emetics (metoclopramide, domperidone, haloperidol) - Side effects
EPSE (bar domperidone)
Hyperprolactinameia
Erectile dysfunction
QT and domperidone
Prolonging
Domperidone and parkinsons
Does not cross the BBB therefore less risk of EPSE
Ondaesteron and QT
Prolonging
Ondaesteron interactions
QT prolonging drugs
Hepatic enzyme inducers
Carbamazepine (anti-emetic effects)
Cyclizine considerations
Can cause antimuscarnic side effects- consider the burden as can lead to dry mouth, urinary retention, constipation, blurred vision
Domperidone age and weight restriction
12+
35kg+
