N17 - CNS infections III

Question 1

Viral Meningitis basic chars:

Answer 1

“aseptic” meningitis
- less severe
- Most commonly from Enterovirus (summer months)
- Herpesvirus (commonly year round)
- arboviruses.

Question 2

Acute enceph - HSV location and sx

Answer 2

Frontal and temporal lobes
- psychosis, impairment of memory, and seizures

Question 3

Acute Enceph - West Nile location and sx

Answer 3

Motor neurons of spinal cord
- flaccid paralysis of the lower extremities

Question 4

Viral etiologies: Human to Human

Answer 4

Enteroviruses (fecal - oral )
Herpesviruses (neural pathway)

Question 5

Mosquito borne

Answer 5

Arboviruses (spread by viremia)

Question 6

Animal to human transmission

Answer 6

Rabies (spread by neural pathway)
LCMV - lympohcytic choriomeningitis virus; rodents;inhalation

Question 7

Arboviruses (arthropod-borne) are have what viral structures?

Answer 7

RNA virus
- Flaviviridae + Toga = ss+RNA enveloped
- Bunyaviridae = ss-RNA enveloped.

Question 8

Arbovirus xmission and life cycle

Answer 8

Vertebrate = reservoir, definitive host (often a bird)
vector = mosquito
humans and horses are dead-end hosts

Question 9

Togaviridae- alphavirus

Answer 9

arboviruses - mild systemic disease, encephalitis

Question 10

Flaviviridae - Flaviviruses

Answer 10

Arboviruses - mild systemic disease, enceph, epatitis, hemorrahge, shock
- St. Louis, West Nile, yellow fever virus, dengue virus