NA-FASI-Antimyco Rationale

Question 1

Which is/are respiratory quinolones:

Moxifloxacin
Levofloxacin
Both
Neither

Answer 1

Both

Question 2

Adverse reaction of crystalluria is associated with

Answer 2

Sulfonamide

Question 3

Adverse reaction of ototoxicity is associated with

Answer 3

Capreomycin

Question 4

Activity against Mycobacterium tuberculosis:

Levoflaxacin _ Ciprofloxacin

Answer 4

Levoflaxacin > Ciprofloxacin

Question 5

Which is/are bacteriostatic

Isoniazid
Rifampin
Both
Neither

Answer 5

Neither

Question 6

Clinically used for treatment of chlamydial urethritis:

Answer 6

Levofloxacin

Question 7

TRUE OR FALSE

Trimethoprim-sulfamethoxazole is the drug of choice for toxoplasmosis.

Answer 7

TRUE

Question 8

Which is/are respiratory quinolones:

Gemfloxacin
Ciprofloxacin
Both
Neither

Answer 8

Gemfloxacin
Moxifloxacin

Question 9

Adverse effect of nephrotoxicity is associated with:

Ethionamide
Capreomycin
Cycloserine
Aminosalicylic Acid
Bedaquiline

Answer 9

Capreomycin

Question 10

Which is/are bacteriostatic

Isoniazid
Ethambutol
Pyrazinamide

Answer 10

Ethambutol
Pyrazinamide

Question 11

Classify: Sulfamethoxazole

Oral Absorbable Sulfonamide
Oral Nonabsorbable Sulfonamide
Topical Sulfonamide

Answer 11

Oral Absorbable Sulfonamide

Question 12

Which is/are respiratory quinolones:

Moxifloxacin
Ciprofloxacin
Both
Neither

Answer 12

Moxifloxacin

Question 13

Which is/are hepatotoxic:

Pyrazinamide
Rifampin
Both
Neither

Answer 13

Pyrazinamide

Question 14

Which is/are generally bactericidal?

Ethambutol
Rifampin
Both
Neither

Answer 14

Rifampin

Question 15

Mechanism of action of Trimethoprim

Inhibits topoisomerase IV
Inhibits dihydropteroate synthase
Both
Neither

Answer 15

Neither

Question 16

TRUE or FALSE

Sulfonamides stimulates growth Rickettsiae

Answer 16

TRUE

Question 17

Adverse effect of granulocytopenia is associated with:

Ethionamide
Capreomycin
Cycloserine
Aminosalicylic Acid
Bedaquiline

Answer 17

Aminosalicylic Acid

Question 18

Adverse reaction of Steven-Johnson syndrome is associated with:

Sulfonamide
Trimethoprim
Ciprofloxacin

Answer 18

Sulfonamide

Question 19

This inhibits RNA synthesis by binding to bacterial DNAdependent RNA pol

Isoniazid
Rifampin
Pyrazinamide
Ethambutol
Streptomycin

Answer 19

Rifampin

Question 20

Adverse reaction of hemolytic anemia is associate with:

Sulfonamide
Trimethoprim
Ciprofloxacin

Answer 20

Sulfonamide

Question 21

Anti-leprosy drug which can cause hemolysis in G6PD deficient patients

Dapsone
Clofazimine
Rifampin
Isoniazid

Answer 21

Dapsone

Question 22

This disrupts mycobacterial cell membrane

Isoniazid
Rifampin
Pyrazinamide
Ethambutol
Streptomycin

Answer 22

Pyrazinamide

Question 23

Mechanism of Action of Sulfonamides

Inhibits DNA gyrase
Inhibits topoisomerase IV
Both
Neither

Answer 23

Neither

Question 24

TRUE or FALSE

Trimethorpim-sulfamethoxazole is the drug of choice for nocardiosis

Answer 24

TRUE

Question 25

# Mechanism of action of Quinolones Inhibits DNA gyrase Inhibits dihydrofolate reductase inhibits topoisomerase IV

Answer 25

Inhibits DNA gyrase inhibits topoisomerase IV

Question 26

# Hepatic biotransformation of absorbed sulfonamide includes: Sulfation Acetylation Methylation Glucoronidation

Answer 26

Acetylation Glucoronidation

Question 27

# Which drug combination is used to treat falciparum malaria: Sulfamethoxazole + Trimethoprim Sulfadiazine + Pyrimethamine Clofazimine + Pyrazinamide Sulfadoxine + Pyrimethamine

Answer 27

Sulfadoxine + Pyrimethamine

Question 28

# Drug of choice for prophylaxis against disseminated M. avium complex MAC Azithromycin Clarithromycin Rifabutin

Answer 28

Azithromycin Clarithromycin Rifabutin din ata | lahat ba?

Question 29

# Clinically used for menigococcal carrier: Ciprofloxacin Levofloxacin Both Neither

Answer 29

Ciprofloxacin Levofloxacin

Question 30

# Drug of choice for treatment of anthrax: Ciprofloxacin Levofloxacin Norfloxacin Ofloxacin

Answer 30

Ciprofloxacin

Question 31

# Clinically used for treatment of gonococcal infection: Ciprofloxacin Levofloxacin Both Neither

Answer 31

Neither

Question 32

# Which can cross the blood brain barrier with inflammed meninges Pyrazinamide Ethambutol Rifampin Isoniazid

Answer 32

Pyrazinamide Ethambutol Isoniazid

Question 33

** Clinically used to treat tuberculosis in patients with HIV infection on antiretroviral therapy ** Rifabutin Rifapentin Both Neither

Answer 33

rifabutin

Question 34

# Adverse effect of QTc interval prolongation is associated with: Gemfloxacin Moxifloxacin Both Neither

Answer 34

Gemfloxacin Moxifloxacin Levofloxacin

Question 35

# Oral sulfisoxazole is indicated for: Simple urinary tract infections Ocular infections Burn infections Ulcerative colitis or rheumatoid arthritis Toxoplasmosis

Answer 35

Simple urinary tract infections

Question 36

**“Megaloblastic anemia, leukopenia, and granulocytopenia are predictable adverse effects of:"** Sulfonamide Trimethoprim Beta-lactam Quinolone

Answer 36

Trimethoprim

Question 37

# MOA is mycolic acid synthesis inhibitor Ethionamide Capreomycin Cycloserine Aminosalicylic Acid Bedaquiline

Answer 37

Ethionamide

Question 38

# MOA is protein synthesis inhibitor Ethionamide Capreomycin Cycloserine Aminosalicylic Acid Bedaquiline

Answer 38

Capreomycin

Question 39

# Which is active against intracellular tubercle bacilli Isoniazid Pyrazinamide Both Neither

Answer 39

Both

Question 40

# Clinically used for treatment of chlamydial urethritis: Ofloxacin Levofloxacin Both Neither

Answer 40

Both

Question 41

# TRUE or FALSE Trimethoprim inhibits the secretion of creatinine in the distal renal tubule

Answer 41

TRUE

Question 42

**As antimetabolites of PABA, there are competitive inhibitors of dihydropteroate synthase** Sulfonamide Trimethoprim Pyrimethamine Quinolone

Answer 42

Sulfonamide

Question 43

# Which is/are hepatotoxic Isoniazid Pyrazinamide Both Neither

Answer 43

Both

Question 44

# Activity against atypical mycobacteria Levofloxacin > Ciprofloxacin Levofloxacin < Ciprofloxacin Levofloxacin = Ciprofloxacin

Answer 44

Levofloxacin > Ciprofloxacin

Question 45

# TRUE or FALSE Silver sulfadiazine is more toxic topical sulfoniamide than mafenide

Answer 45

FALSE

Question 46

**Acute hemolysis in patients with glucose-6-phosphate dehydrogenase deficiency is observed with:** Sulfonamide Trimethoprim Beta lactam Quinolone

Answer 46

Sulfonamide

Question 47

# Absorbed Sulfonamides are removed from the body by: Urinary glomerular filtration Biliary excretion Both Neither

Answer 47

Urinary glomerular filtration

Question 48

**Adverse reaction of Drug-induced systemic lupus erythematosus is associated with:** Isoniazid Rifampin Pyrazinamide Ethambutol Streptomycin

Answer 48

Isoniazid

Question 49

# Which is/are enzyme inhibitor Isoniazid Pyrazinamide Both Neither

Answer 49

Isoniazid

Question 50

# Which is/are enzyme inducer Ethambutol Rifampin

Answer 50

Rifampin

Question 51

# Adverse reaction of red-green color blindness is associated with: Isoniazid Rifampin Pyrazinamide Ethambutol Streptomycin

Answer 51

Ethambutol

Question 52

# Anti-leprosy drug which can cause erythrema nodosum leprosum Dapsone Clofazimine Rifampin Isoniazid

Answer 52

Dapsone

Question 53

# Anti-leprosy drug which can cause Methemoglobinemia Dapsone Clofazimine Rifampin Isoniazid

Answer 53

Dapsone

Question 54

**This inhibits arabinoglycan polymerization by binding to arabinosyl transferase** Isoniazid Rifampin Pyrazinamide Ethambutol Streptomycin

Answer 54

Ethambutol

Question 55

# Activity against M. tuberculosis Moxifloxacin < Levofloxacin Moxifloxacin > Levofloxacin Moxifloxacin = Levofloxacin

Answer 55

Moxifloxacin > Levofloxacin

Question 56

# Adverse reaction of acute tubular necrosis is associated with Isoniazid Rifampin Pyrazinamide Ethambutol Streptomycin

Answer 56

Rifampin

Question 57

# **TRUE or FALSE** fluoroquinolones were originally developed against Gram-positive aerobic bacteria

Answer 57

FALSE

Question 58

**Granulocytopenia, thrombocytopenia, and aplastic anemia is a hematologic toxicity of:** Sulfonamide Trimethoprim Beta lactam Quinolone

Answer 58

Sulfonamide

Question 59

**This inhibits mycolic acid synthesis by binding to beta-ketoacyl protein synthetase** Isoniazid Rifampin Pyrazinamide Ethambutol Streptomycin

Answer 59

Isoniazid

Question 60

# **TRUE or FALSE** Trimethoprim is less lipid-soluble than sulfamethoxazole.

Answer 60

False

Question 61

# Clinically used against Shigellosis for children TMP-SMZ Ciprofloxacin Both Neiter

Answer 61

Ciprofloxacin

Question 62

# Adverse effect of cardiac toxicity is associated with Ethionamide Capreomycin Cycloserine Aminosalicylic Acid Bedaquiline

Answer 62

Bedaquiline

Question 63

# Oral triple sulfa is indicated for: Simple urinary tract infections Ocular infections Burn infections Ulcerative colitis or rheumatoid arthritis Toxoplasmosis

Answer 63

Simple urinary tract infections

Question 64

# **TRUE or FALSE** Topoisomerase IV inhibition prevents the relaxation of supercoiled DNA.

Answer 64

FALSE

Question 65

# MOA is cell wall synthesis inhibitor Ethionamide Capreomycin Cycloserine Aminosalicylic Acid Bedaquiline

Answer 65

Cycloserine

Question 66

# MOA is folate synthesis inhibitor Ethionamide Capreomycin Cycloserine Aminosalicylic Acid Bedaquiline

Answer 66

Aminosalicylic Acid

Question 67

# Adverse reaction of hyperuricemia is associated with Isoniazid Rifampin Pyrazinamide Ethambutol Streptomycin

Answer 67

Pyrazinamide

Question 68

# **TRUE or FALSE** Lomefloxacin may cause photosensitivity.

Answer 68

TRUE

Question 69

# **TRUE or FALSE** Trimethoprim-sulfamethoxazole is the drug of choice for Pneumocystis pneumonia.

Answer 69

TRUE

Question 70

**This is administered to minimize bone marrow suppression caused by pyrimethamine** Clofazimine Pyridoxine Plazomicin Leucovorin

Answer 70

Leucovorin

Question 71

# Activity against M. tuberculosis Levofloxacin > Ciprofloxacin Levofloxacin < Ciprofloxacin Levofloxacin = Ciprofloxacin

Answer 71

Levofloxacin > Ciprofloxacin

Question 72

# This is an inhibitor of dihydrofolate reductase pyrimethamine sulfonamide quinolone beta lactam

Answer 72

pyrimethamine

Question 73

# Adverse effect of crystalluria is associated with Ethionamide Capreomycin Cycloserine Aminosalicylic Acid Bedaquiline

Answer 73

Aminosalicylic Acid

Question 74

**This weakly acidic compound that have a common chemical nucleus resembling p-aminobenzoic acid (PABA)** sulfonamide trimethoprim pyrimethamine quinolone

Answer 74

sulfonamide

Question 75

**Adverse reaction of crystalluria is associated with** Sulfonamide Trimethoprim Ciprofloxacin

Answer 75

Sulfonamide

Question 76

# Hepatic biotransformation of absorbed sulfonamide includes methylation glucuronidation both neither

Answer 76

glucuronidation

Question 77

**Anti-leprosy drug which can be used to treat Pneumocystis jiroveci in AIDS patients** Dapsone Clofazimine Rifampin Isoniazid

Answer 77

Dapsone

Question 78

# Anti-leprosy drug which inhibit folate synthesis Dapsone Clofazimine Rifampin Isoniazid

Answer 78

Dapsone

Question 79

# Which has the longest half-life? Ofloxacin Levofloxacin Moxifloxacin Gemifloxacin

Answer 79

Moxifloxacin

Question 80

# Anti-leprosy drug which can cause discoloration of the skin Dapsone Clofazimine Rifampin Isoniazid

Answer 80

Clofazimine

Question 81

# **TRUE or FALSE** Pseudomonas is intrinsically resistant to sulfonamides.

Answer 81

TRUE

Question 82

# Clinically used against UTI for children TMP-SMZ Ciprofloxacin Both Neither

Answer 82

TMP-SMZ

Question 83

# Classify: Sulfadiazine-pyrimethamine Oral Absorbable Sulfonamide Oral Nonabsorbable Sulfonamide Topical Sulfonamide

Answer 83

Oral Absorbable Sulfonamide

Question 84

# Adverse effect of psychosis is associated with

Question 85

# Mechanism of action of Sulfonamides inhibits topoisomerase IV inhibits dihydropteroate synthase Both Neither

Answer 85

inhibits dihydropteroate synthase

Question 86

# Adverse effect of depression is associated with Ethionamid Capreomycin Cycloserine Aminosalicylic Acid Bedaquiline

Answer 86

Cycloserine

Question 87

# Oral sulfa-salazine is indicated for: Simple urinary tract infections Ocular infections Burn infections Ulcerative colitis or rheumatoid arthritis Toxoplasmosis

Answer 87

Ulcerative colitis or rheumatoid arthritis

Question 88

# Which is nephrotoxic Sulfonamide Trimethoprim Both Neither

Answer 88

Sulfonamide

Question 89

**This selective inhibitor of bacterial dihydrofolate reductase that prevents formation of the active tetrahydro form of folic acid** trimethoprim sulfonamide beta lactam quinolone

Answer 89

trimethoprim

Question 90

# **TRUE or FALSE ** Sulfonamides stimulates growth of Ricketsiae.

Answer 90

TRUE