nAChR Flashcards
what kind of channel is nAChR
integral ion channel
transmitter gated ion channel
what happens when an agonist binds to the receptor
induces a RAPID conformational change
how quick is the signalling
extremely rapid
what is alpha bungaratoxin
a selective high affinity antagonist
what is a vesamicol
a drug inhibits vesicular uptake of ACh
what happens when a vesamicol inhibits vesicular uptake of ACh
decreases the amplitude of mepps
black widow spider venom (alpha latrotoxin) influences what
spontaneous transmitter release
alpha latrotoxin involves what complex mechanism
Ca dependant and Ca independent pathways
where does alpha-LTX bind to presynaptically
G protein coupled receptors
what does alpha LTX form
an alpha LTX channel
cation conducting pore channel
what is the structure of nACh
pentameric
at family does it belong to
cys loop family
what is orthoosteric
agonsit to nAChR
what does ACh binding protein exist as
a homo pentamer
