nAchR Flashcards Preview

Physiology Exam 5 > nAchR > Flashcards

Flashcards in nAchR Deck (12):
1

nACh receptor is located at?

Neuromuscular junction

2

nACh receptor is a?

Heteropentamer

3

ACh binds to what subunit?

alpha

4

nAChR agonists

1. Nicotine
2. Carbamylcholine
2. Succinylcholine
3. Levamisole
4. Pyrantel target helminth homolog

5

nAchR antagonists

1. Trimethaphan
2. alpha Bungarotoxin
3. Curare

6

Trimethaphan is a?

Ganglionic block

7

What subunit lines pore of nAchR?

M2 → determines ion selectivity

8

nAchR is nonselective for?

Monovalent cations (Na+ and K+)

9

What subunit of nAchR determines ligand affinity?

alpha → one binding site per alpha subunit

10

What subunit of nAchR determines localization?

beta

11

All forms of nAchR contain how many alpha subunits?

2

12

When nAchR causes cation channels to open, what happens?

Depolarization