Naloxone

Question 1

Naloxone- Name

Answer 1

Narcan

Question 2

Naloxone- Class

Answer 2

Narcotic (Opiate) Antagonist

Question 3

Naloxone- MoA

Answer 3

Reverses the respiratory depression and CNS sedation of narcotics by competing for opiate receptor sites in the brain

Question 4

Naloxone- Indications

Answer 4

Known or suspected narcotic overdoses with inadequate respiratory function

Question 5

Naloxone- Contra

Answer 5

Not be used if patient has adequate respiratory status

Question 6

Naloxone- S/E

Answer 6

Cardiovascular: tachycardia, hypertension, dysrhythmias

Neurological: tremors/seizures, aggressive/combative

Gastrointestinal: nausea/vomiting

Question 7

Naloxone- Routes

Answer 7

IV, IO, IM, IN, ET

Question 8

Naloxone- A. Dose

Answer 8

1.0 – 2.0 mg IV/IM/IN.

Titrate IV dose to adequate respiratory rate and tidal volume.

May repeat dose every 5 minutes as needed

Question 9

Naloxone- P. Dose

Answer 9

0.1 mg/kg IV/IM/IN.

Titrate IV dose to adequate respiratory rate and tidal volume.

May repeat dose every 5 minutes as needed

Question 10

Naloxone- EXTRAS

Answer 10

Precautions: Give drug prior to intubation

Prepare to protect patient and EMS personnel due to aggressive/combative personality following rapid reversal of a narcotic overdose

Does not reverse narcotic-induced hypotension

Use with caution in narcotic addicts or chronic pain patients, as Narcan will rapidly reverse the CNS depressant effects of opiods.

Immediate onset when administered IV/IO/IN/ET and 5-10 minutes if administered IM. Either may last 20-30 minutes

Darvon and other synthetic narcotics may require larger dosages to reverse the effects