Nanodropper Qs

Question 1

What is the total volume of liquid the eye can hold?

Answer 1

30 microliters (uL)

Question 2

What is the eye absorption capacity?

Answer 2

7-10 uL

Question 3

Why are these numbers different?

Answer 3

When the eye is filled to it’s brim, the stimulus of so much liquid entering the eye results in volume-dependent reflexes including blinking, tearing, and drainage. These reflexes contribute to medication dilution and more rapid clearance from the eye. Only about 7-10 microliters actually stays in the eye to be absorbed.

Question 4

What volume do current eyedrop bottles dispense?

Answer 4

35-70 uL

Question 5

What volume does the Nanodropper dispense?

Answer 5

Typically about 10-15 uL (importantly, never less than 10 uL)

Question 6

How many eyedrops per mil do you usually get for regular drops?

Answer 6

Regular bottles administer about 20-25 drops per milliliter of fluid. This is a way to estimate the number of doses in a bottle (there are 100 microliters (uL) per milliliter (mL), e.g. a 5 milliliter bottle contains about 100 regular sized drops.

Question 7

How many drops per mil would you get out of a bottle using a Nanodropper tip?

Answer 7

~60-100

Question 8

What property of eyedrops has the greatest effect on drop volume?

Answer 8

Viscosity

Question 9

What are the three types of medication formulations?

Answer 9

Solutions, suspensions, emulsions

Question 10

What type of formulation tends to clog the tip?

Answer 10

Suspensions –> NanoTip: tap the bottle on a counter top after administering a suspension drop to avoid clogging

Question 11

With the Nanodropper, what type of formulation has the largest drop?

Answer 11

Typically emulsions (these are oil-based drops and tend to be thicker)

e.g. Restasis

Question 12

How much longer do bottles last with Nanodropper?

Answer 12

3x

Question 13

What was the exact average bottle life extension observed in our benchtop study?

Answer 13

2.6x

Study name: Reduction of Eyedrop Volume for Topical Ophthalmic Medications with the Nanodropper Bottle Adaptor

Question 14

Which bottles can I use Nanodropper with in my clinic?
Name at least three!

Answer 14

The Nanodropper is compatible with almost all in-clinic drops (proparacaine, Paremyd, tropicamide, phenylephrine, etc.) except Fluress / Fluorescein.

Compatibility with the Nanodropper Adaptor depends on the diameter of the threads on the bottle neck (9/16 in, ~15mm).

Any other bottles in your clinic that have the same size thread diameter as the bottles listed above will be compatible as well!

Visit www.Nanodropper.com/comp for more information.

Question 15

What is the most common in-office drop we are NOT compatible with?

Answer 15

Fluress. It is a glass bottle, so you cannot squeeze it, plus Nanodropper does not fit the threads. Fluress also gets gunky and will clog the tip.

Question 16

What is the broad category of medications we are never compatible with?

Answer 16

Preservative free (PF)

Question 17

Why are we not compatible? (2 reasons)

Answer 17

We do not fit on the single-use vials or multidose PF bottles and there would be risk of contamination because Nanodropper allows air intake into our tip

Question 18

What is the benefit of Nanodropper for preservative containing drops?

Answer 18

Nanodropper may reduce preservative exposure, reducing the ocular surface toxicity and side effects. A recent study showed microvolume delivery resulted in less inflammatory expression in corneal epithelial cells in vitro.

Question 19

What are the three types of patient issues that Nanodropper helps solve?

Answer 19

Early bottle exhaustion, patients who spend $10 or more out of pocket for drops, patients with tolerability/side effect concerns

Question 20

What is the breakeven out-of-pocket cost for patients to save money with Nanodropper?

Answer 20

$10

Question 21

What are the top 4 indications for patients to use Nanodropper?

Answer 21

Glaucoma, post-op drops, mild to moderate dry eye, pediatric myopia (for diluted atropine)

Question 22

What resource, in addition to money, can Nanodropper save clinics?

Answer 22

Administrative time - utilizing Nanodropper reduces early refill request calls.

Question 23

What are some ways that Nanodropper improves barriers to instilling an eyedrop for patients?

Answer 23

Nanodropper has a pop-off cap and it takes less pressure to squeeze a drop out of the bottle. Hold the bottle completely upside down (not at an angle) to ensure a consistent drop size, and make sure the drop doesn’t bead up on the tip. This is best practice with ALL bottles, with or without Nanodropper!

Question 24

Is the Nanodropper reusable?

Answer 24

No!

The Nanodropper Adaptor is a Class I, FDA-listed, sterile medical device. The Nanodropper should NOT be transferred between bottles of eyedrops.

We recommend using one adaptor per medication to prevent risk of contamination and injury. Since the Nanodropper triples the life of your eyedrop bottles, the savings will pay for the adaptor and much more.

We use gamma radiation for sterilization to promote a high level of patient safety. The Nanodropper CANNOT be autoclaved.