Nanotechology 🔬 Flashcards
Advantages of nanosizing [8]
- Surface area = INCREASED
- solubility = ENHANCED
- Rate of dissolution = increased
- Oral bioavailability = Increased
- Onset of action = rapid
- Amount of dose required = less
- Fasting and fed variability = Decreased
- Patient to patient variability = decreased
Non polymer [4]
Carbon nanotubes
Quantum dots
Metallic nanoparticles
Silica nanoparticiles
Structure of
QUANTUM DOTS
Semi conductor core
+
Coated by shell (ZnS) = improves optical properties
+
Cap = enables solubility in Aqueous buffers
Are QUANTUM DOTS
atomic or bulk semiconductors ?
No!!!!
Name POLYMER nanoparticles [5]
Dendrimers
Polymer nanoparticles
Polymeric Micelles
Liposomes
Polymer drug conjugate
What are the 3 regions of dendrimers
Core
Branch
Surface
Name the 2 classes of polymeric nanoparticles
1
Vesicular system = nano capsules
[Drug in cavity surrounded by polymeric membrane]
2
Matrix system = nanospheres
[ drug dispersed throughout polymeric matrix]
Name some NATURAL POLYMERS
+ disadvantages?
Gelatin
Albumin
Alginate
Disadvantages =
- Poor batch to batch reproductively
- prone to degradation
- potential antigenicity
Name some SYNTHETIC POLYMERS
Polycaprolactone
Poly lactic acid
Describe the design of
POLYMERIC MISCELLES
Amphilitic BLOCK Copolymers
Assembled into
Nanoscopic supramolecular core shell structures
What are polymeric Micelles especially used for
Systemic delivery of water insoluble drugs
(As they have hydrophobic cores shielded from water by a mantle of hydrophobic groups)
How do LIPOSOMES work
Drug molecules can be either
Entrapped in the aqueous space OR
intercalated into the lipid bilayer of liposomes
(Depending on physiochemical characteristics of thr drug)
Why have they designed POLYMER DRUG CONJUGATES
TO INCREASE THE OVERALL molecular Weight = which facilitates in the retention in cancer cells through enhanced PERMEATION and RETENTION = using passive delivery approach
