NAPLEX **

Question 1

epzicom

Answer 1

lamivudine and abacavir

both NRTIs

Question 2

triumeq

Answer 2

lamivudine, abacavir, dolutegravir

a preferred option in treatment naive patients

Question 3

Genvoya

Answer 3

cobicistat, elvitegravir, emtricitabine, tenofovir AF
strong 3A4 inhibitor
first line, single pill

Question 4

elvitegravir considerations

Answer 4

do not administer with polyvalent cations

Question 5

NRTIs

Answer 5

cause DNA chain termination, blocking viral DNA synthesis by reverse transcriptase
entire class has a boxed warning for lactic acidosis
do not undergo transformation via CYP450
require renal dose adjustments, except for abacavir

Question 6

truvada

Answer 6

emtricitabine + tenofovir disoproxil fumarate

Question 7

Viread

Answer 7

tenofovir DF

NRTI

Question 8

rilpivirine side effects

Answer 8

in complera

depression, mood changes, insomnia, suicidal idealation

Question 9

HIV medication that can cause asymptomatic jaundice

Answer 9

Reyetaz (atazanavir) “bananavir”

Question 10

protease inhibitor recommended in a preferred regimen for treatment-naive paitents

Answer 10

Darunavir

Question 11

PEP duration

Answer 11

4 weeks

Question 12

Isentress

Answer 12

raltegravir
avoid polyvalent cations (give 2 hours before or 6 hours after)
400 BID or 1200 daily both appropriate
can give with food
can increase CPK

Question 13

PrEP medications

Answer 13

truvada
(emtricitabine + TDF)
will require HIV testing q3months during PrEP

Question 14

complera

Answer 14

emtricitabine + TDF + rilpivarine

Question 15

prezista

Answer 15

darunavir
should always be given with boosting agent (ritonavir or cobicistat), has a sulfa moiety so should be used with caution in allergy, st johns wort can decrease levels, take with food, monitor lipids and glucose

Question 16

Zidovudine

Answer 16

IV formulation used to prevent perinatal transmission during delivery

Question 17

CCR5 testing required before starting

Answer 17

maraviroc

will only be effective in CCR5-tropic disease

Question 18

PPIs are contraindicated with what HIV meds?

Answer 18

rilpivirine (Edurant) containing products

i.e. complera, edurant, odefsey

Question 19

HIV medications to take with food

Answer 19

most PIs to decrease GI upset

i.e. edurant, prezista, reyataz

Question 20

HIV meds that should be taken on an empty stomach at bedtime

Answer 20

sustiva (efavirenz) and atripla (efavirenz + emtricitabine + TDF)

Question 21

descovy

Answer 21

emtricitabine + TAF

Question 22

stribild in renal impairment

Answer 22

cobicistat increases Cr (without damaging kidneys), tenofovir causes nephrotoxicity
do not start if less than 70, d/c if less than 50
genvoya can be used until CrCl less than 30

Question 23

cobicistat use

Answer 23

3A4 inhibitor to boost levels

Question 24

stribild

Answer 24

elvitegravir + cobicistat + emtricitabine + TDF

Question 25

abacavir

Answer 25

Ziagen risk of serious, possibly fatal hypersensitivty reaction If HLA-B*5701 positive, do NOT give abacavir + lamivudine is Epzicom

Question 26

symbicort ingredients

Answer 26

formoterol + budesonide

Question 27

airduo ingredients

Answer 27

fluticasone + salmeterol

Question 28

theophylline levels

Answer 28

peak at SS 5-15

Question 29

humulin n stable at room temp for

Answer 29

14 days

Question 30

leukocytosis vs leukopenia

Answer 30

``` cytosis = high penia = low ```

Question 31

digoxin level

Answer 31

0. 5-0.9 for HF | 0. 8-2 for AF

Question 32

max lifetime dose of bleomycin

Answer 32

400 units sue to risk of pulmonary toxicity

Question 33

chemo pulmonary fibrosis agents

Answer 33

carmustine, busulfan, bleomycin, and lomustine

Question 34

rituximab PG testing

Answer 34

CD20 positive to use

Question 35

rituximab can activate what?

Answer 35

Hep B

Question 36

max dose of vincristine

Answer 36

2 mg

Question 37

cetuximab PG testing *

Answer 37

EGFR | KRAS negative

Question 38

simvastatin and diltiazem

Answer 38

max simvastatin dose 10 mg due to 3A4 | max simvastatin dose 20 mg with ranolazine

Question 39

niacin side effects

Answer 39

increased blood sugar, increased uric acid, flushing and/or itching

Question 40

niaspan administration

Answer 40

at bedtime after a low-fat snack

Question 41

lovaza side effects

Answer 41

burping, dyspepsia, taste perversions

Question 42

fenofibrate contraindications

Answer 42

severe liver disease, gallbladder disease

Question 43

odefsey

Answer 43

rilpivirine + emtricitabine + TAF | same as complera (TDF) but TAF

Question 44

tivicay

Answer 44

dolutegravir | INSTI

Question 45

fuzeon

Answer 45

enfuvirtide SC inj almost 100% experience inj site reactions

Question 46

drugs that can increase LDL

Answer 46

fenofibrate, geodon, dexamethasone, lovaza

Question 47

mipomersin contraindication

Answer 47

mod-severe hepatic impairment or hepatic disease

Question 48

myalept indication

Answer 48

leptin deficiency with congenital or acquired generalized lipodystrophy