Narcolepsy Flashcards
1
Q
HLA association in narcolepsy
A
HLA-DR2
2
Q
Why do patients with narcolepsy have early onset sleep
A
- low levels of orexin (hypocretin) which is responsible for controlling appetite and sleep patterns
3
Q
Clinical features
A
- hypersomnolence
- cataplexy (sudden loss of muscle tone)
- sleep paralysis
- vivid hallucinations
4
Q
Typical age of onset
A
Teenage years
5
Q
investigation for diagnosis of narcolepsy
A
multiple sleep latency EEG
6
Q
Management of narcolepsy
A
daytime stimulants (e.g. modafinil)
night-time sodium oxybate
7
Q
A
