Nause and vomiting treatment Flashcards Preview

Gastrointestinal Pharmacology > Nause and vomiting treatment > Flashcards

Flashcards in Nause and vomiting treatment Deck (18)
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1
Q

What is sialorrhea?

A

Increased secretion of daliva rhat slows through the mouth

2
Q

What is arcade?

A

Violent mocmeent of tbe stomach and esophagus to induce vomiting

3
Q

What is kinetosis?

A

Motion sickness, fatigue, loss of balance, nausea and vomiting

4
Q

Vomiting triggers what?

A

The release of mediators such as 5-HT by the enterochromaffin cells in the linning of the digestive tract

5
Q

The neurotransmitters invovled in vomiting activate what?

A

Signals in the vagal afferent nerve fibers

6
Q

Vomiting is more in common in which demographic?

A

Peoole between the ages of 15-24 years of age. Less frequent in children and the elderly

7
Q

Which is a common complication in the post operative period?

A

Nausea and vomiting

8
Q

What is one of the most distressing sode effects of the cancer treatment?

A

Nause and vomiting

9
Q

What happens in the pre expulsion period?

A

Gastric relaxation and retro-peristalsis

10
Q

What is retch?

A

Rythmic action of the respiratory muscles that precedes vomiting and consists of contraction of the abdominal and intercostal muscles and the diaphragm ahaisnt a closed glottis that elevates the intra-gastric pressure

11
Q

What happens during expulsion?

A

Intense contraction of the muscles of the abdomen and relaxation of the high esophageal sphincter. A phasic and simultaneous contraction of the pylorus prevents the caudal propulsion of the gastric contents, forcing the opening pf the lower esophageal sphincter after the simultaneous relaxation of the body anf gastric fundus

12
Q

Cinnarizine is indicated for?

A

Vertigo/meniers disease/ nausea and vomiting/motion sickness/vestibular symptoms of other origins

13
Q

Cinnarizine is an antagonist of which receptors?

A

Histamine H1 receptor
Voltage-dependant L-type calcium channel
Voltage-dependant T-type calcium channel

14
Q

Cinnarizine is a binder of?

A

Dopamine receptor D1 and D2

Muscarinic acetylcholine receptor

15
Q

Dimenhydrinate is an anti emetics drug combination that contains diphenhydramine and ?

A

Theophylline

16
Q

What are the indications of dimenhydrinate?

A

Prevention of nausea, vomiting or vertigo of motion sickness (important)

17
Q

Is dimenhydrinate effective at treating nausea associated with cancer therapy?

A

No

18
Q

What is the mechanism of action of dimenhydrinate?

A

Competitive antagonist at the H1 receptor