Necrosis. L39

Question 1

Def of Necrosis

Answer 1

local death of group of cells in the living tissue.

Question 2

Gross picture in necrosis

Answer 2

Necrotic area appears opaque and surrounded by red zone of inflammation

Question 3

Microscopic picture are one of those?

Answer 3

Cytoplasmic changes
Nuclear changes

Question 4

Cytoplasmic changes in necrosis

Answer 4

a- The cells become swollen (cytomegaly)
b- Increased eosinophilia
c- The cytoplasm becomes vacuolated
d- Finally the cell membrane ruptures

Question 5

Nuclear changes inn necrosis

Answer 5

a- Pyknosis
b- Karyorrhexis
c- Karyolysis

Question 6

What happens in Karyolysis

Answer 6

Lysis and dissolution of the nuclear chromatin

Question 7

nuclear shrinkage occurs in?

Answer 7

Pyknosis

Question 8

Fragmentation of nuclear material occurs in?

Answer 8

Karyorrhexis

Question 9

Fate of necrosis?

Answer 9

1- Small area of necrosis
2- Large area of necrosis

Question 10

In Small area of necrosis?

Answer 10

Necrotic tissue is removal by macrophages

Question 11

In Large area of necrosis?

Answer 11

Surrounded by fibrous capsule

Question 12

Types of necrosis

Answer 12

1- Coagulative necrosis
2- Liquifactive necrosis
3- Caseating necrosis
4- Fat necrosis
5- Fibrinoid necrosis

Question 13

Most common type of necrosis

Answer 13

Coagulative necrosis

Question 14

Cause of necrosis

Answer 14

sudden cut of blood supply (ischemia)

Question 15

Site of Coagulative necrosis?

Answer 15

all organs except the brain

Question 16

Gross pic of Coagulative necrosis

Answer 16

firm and opaque white

Question 17

Microscopic picture Coagulative necrosis

Answer 17

Dead tissues shows preserved architecture (ghosts of cells) for a span of at least some days with no cell details

Question 18

Define Liquifactive necrosis

Answer 18

Type of necrosis characterized by softening and liquefaction of the necrotic tissue

Question 19

Examples of Liquifactive necrosis ? They happen due to?

Answer 19

a-Brain infarctions: due to high lipid and fluid content
b- Pyogenic abscess due to liquefaction of necrotic tissue by proteolytic enzymes.

Question 20

In Liquifactive necrosis ……… is dominant than …….

Answer 20

enzymatic digestion
denaturation

Question 21

Liquifactive necrosis makes The necrotic area what?

Answer 21

becomes soft and liquefied in?

Question 22

Caseation necrosis occurs in which disease?

Answer 22

Tb

Question 23

Caseation necrosis looks like?

Answer 23

cheese like

Question 24

local area of fat destruction

Answer 24

Fat necrosis

Question 25

Fat necrosis is two types name them?

Answer 25

Traumatic fat necrosis Enzymatic fat necrosis

Question 26

Occcurs to adipose tissue (e.g. breast ) → rupture of fat cells

Answer 26

Traumatic fat necrosis

Question 27

It occurs in acute pancreatitis

Answer 27

Enzymatic fat necrosis

Question 28

Describe Enzymatic fat necrosis

Answer 28

It occurs in acute pancreatitis → release of pancreatic enzymes into the substance of the pancreas or the peritoneal cavity → enzymes liquefy fat cells with release of fatty acids that combine with calcium to produce grossly visible chalky-white areas (fat saponification)

Question 29

FIBRINOID NECROSIS site

Answer 29

in blood vessels (vasculitis)

Question 30

Causes of FIBRINOID NECROSIS

Answer 30

Deposits of fibrin like material in the walls of arteries in immunological reaction

Question 31

Microscopic picture of FIBRINOID NECROSIS (color)

Answer 31

bright pink appearance