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Pharmacology of Ion Channels > Neil Marrion Drugs > Flashcards

Neil Marrion Drugs Flashcards

1
Q

Non-selective VGKC blocker

A

TEA - binds to tyrosine in P-loop

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2
Q

SK channel blocker (experimentally)

A

Apamin

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3
Q

BK channel blocker (experimentally)

A

Paxilline

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4
Q

M current enhancer

A

Retigabine (1 subunit = functional block)

ICA73 = stronger (4 subunits = functional block)

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5
Q

M current blocker

A

Linopiridine

Cognitive enhancer - vascular dementia + age-related cognitive enhancer

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6
Q

SK therapeutic

A

1-EBIO = SK2/3 enhancer
As dose increased, mAHP increased and number of mice convulsions decreased

Anti-convulsant

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Pharmacology of Ion Channels (9 decks)

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