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Microbiology Midterm > Neisseria > Flashcards

Neisseria Flashcards

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1
Q

Neisseria characteristics part 2

A 
Pairs - diplococci
Non motile
No spores
Oxidase positive
PMNs
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2
Q

Acid production by oxidation

A

Meningitidis - maltose and glucose

Gonorrhea - glucose only

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3
Q

Growth

A

Nonspecific - blood agar
Specific - Thayer martin (choco agar)
- mueller-Hinton media

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4
Q

Culture on Thayer martin media

A

Elevated colonies
Transparent
Non pigmented
Non hemolytic

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5
Q

Neisseria gonorrhea caharacteristic

A

Gonococcus
35-37c
Poor survival in cold temperature

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6
Q

Neisseria gonorrhea

Structure is typical of gram negative

A

LOS- lipooligosaccharide

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7
Q

Neisseria gonorrhea

Outer space is not converted with a true

A

CHON capsule

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8
Q

Neisseria gonorrhea
Virulence

Pili fimbriae

A

Major virulence factor
Anti phagocytic
Attach to host cells

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9
Q

Neisseria gonorrhea
Virulence

Por proteins A and B

A

Entry of nutrients
Inhibits phagosome-lysosomal fushion
Inhibit anti body reaction by binding to C3b and C4b

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10
Q

Neisseria gonorrhea
Virulence

Express resistant to serum killing, disseminated disease

A

Por A

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11
Q

Neisseria gonorrhea
Virulence

Antigenic variation
Serotype classification
Intracellular survival

A

Por B

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12
Q

Neisseria gonorrhea
Virulence

Opa proteins

A

Adhesion to colonies
Opaque appearance
Attachment to host cell receptors

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13
Q

Neisseria gonorrhea
Virulence

Opa 51-60

A

CEACAM 1,5,6

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14
Q

Neisseria gonorrhea
Virulence

Opa 50

A

Syndecans

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15
Q

Neisseria gonorrhea
Virulence

Opa 52-54, 57-60

A

Endothelial cells
Granulocytes
Lymphocytes

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16
Q

Neisseria gonorrhea
Virulence

Associated with Por protein in the formation of pores in the cell membrane
Stimulate antibodies that block serum bactericidal activity

A

RMP (protein3)

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17
Q

Neisseria gonorrhea
Virulence

Responsible for toxicity
Ciliary loss
Evade immune recognition

A

LOS

Lipooligosaccharide

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18
Q

Neisseria gonorrhea
Virulence

Allow binding to mucosal surface

A

IgA1 protease

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19
Q

Neisseria gonorrhea
Virulence

Resistance to beta lactam antibiotics

A

Beta lactamase

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20
Q

Neisseria gonorrhea
Virulence

Surface expose protein
Heat modifiable like opa protein

A

Lip H8

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21
Q

Neisseria gonorrhea
Virulence

Iron binding protein

A

Fbp

Transferrin
Lactoferrin
Hemoglobin

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22
Q

Neisseria gonorrhea
Epidemiology

Modes of transfusion

A

Sexual

Neonatal

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23
Q

Neisseria gonorrhea
Epidemiology

50% risk developing disease after single exposure

A

Women

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24
Q

Neisseria gonorrhea
Epidemiology

20% risk developing after single exposure

A

Men

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25
Q

Neisseria gonorrhea
Pathogenesis

Gonococci with opaque colonies

A

Men with symptomatic urethritis

Uterine cervical cultures at mid cycle

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26
Q

Neisseria gonorrhea
Pathogenesis

Go cocci with transparent colonies

A

Men asymptomatic
Menstrual women
Salphingitis and disseminated infection

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27
Q

Neisseria gonorrhea
Pathology

Attach to mucous memebranes of the

A

GUT,
Eye
Rectum
Throat

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28
Q

Neisseria gonorrhea
Pathogenesis

Males

A 
Painful urination
Yellow pus
Epididymitis
Prostatitis
Abscess
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29
Q

Neisseria gonorrhea
Pathogenesis

Women

A

Infect endocervical columnar epithelial cells

Extend to urethra and vagina

30
Q

Neisseria gonorrhea
Pathogenesis

Chronic

A

Asymptomatic

31
Q

Neisseria gonorrhea
Clinical findings
Gonococcal bacteremia

Skin lesions

A

Hemorrhagic papules and pustules on hands and feet

32
Q

Neisseria gonorrhea
Clinical findings
Gonococcal bacteremia

A 
Skin lesions
Suppurating arthritis
Endocarditis
Meningitis
Conjunctivitis
Fitz Hugh curtis syndrome
Ano rectal gonorrhea
Pharyngitis
33
Q

Neisseria gonorrhea
Clinical findings
Gonococcal opthalmia neonatorum

Prevention

A

1% tetracycline ointment
5% erythromycin
Silver nitrate

34
Q

Neisseria gonorrhea
Diagnosis

Specimens

A

Pus

Secretions

35
Q

Neisseria gonorrhea
Diagnosis

Blood culture

A

Systemic illness

36
Q

Neisseria gonorrhea
Diagnosis

Special culture system

A

Poly ethanol sulfonate standard in blood culture media

37
Q

Neisseria gonorrhea
Diagnosis

Smears

A

Men

90% sensitivity
99% specificity

Women

50% sensitivity
95% specificity

38
Q

Neisseria gonorrhea
Diagnosis

Culture

A

For women

Not necessary for men if stain is positive

39
Q

Neisseria gonorrhea
Diagnosis

Culture

Selective media for neisseria

A

Thayer martin media
With VNC

Vancomycin - gram positive
Nystatin - yeast and fungi
Colistin - gram negative

40
Q

Neisseria gonorrhea
Diagnosis

Direct detection in GU specimens
Preferred test

A

Nucleic Acid amplification test

NAAT

41
Q

Neisseria gonorrhea
Diagnosis

Immunoblotting
Radioimmunoassay
ELISA

A

Serology

Detect antibodies to gonococcal pili

42
Q

Neisseria gonorrhea
Treatment

CDC recommendation

A

125mg ceftriaxone IM single dose for uncomplicated infection

43
Q

Neisseria gonorrhea
Treatment

For contaminant infection

A

Azithromycin

Doxycycline

44
Q

Neisseria gonorrhea
Treatment

Substitute for doxycycline in pregnant

A

Erythromycin

45
Q

Neisseria gonorrhea
Treatment

CDC recommendation for disseminated infection

A

Ceftriaxone

Alternative
Cefotaxime
Ceftizoxime
Spectinomycin

46
Q

Neisseria menigitidis

Characteristics

A

Capsulated
Nasopharynx colonizer
Human
At least 13 serogroups

47
Q

Neisseria menigitidis

Sero groups

Most important

A

A,B,C,X,Y,W135

48
Q

Neisseria menigitidis

Sero groups

Epidemic disease

A

Group C and A

49
Q

Neisseria menigitidis

Sero groups

Outbreaks and sporadic cases

A

B,C,Y, W135

50
Q

Neisseria menigitidis

Sero groups

Developing countries

A

Group A

51
Q

Neisseria menigitidis

Sero groups

Meningococcal pneumonia

A

Group Y and W135

52
Q

Neisseria menigitidis

Virulence

A

Capsule
Outer membrane (1-5)
Pili
LOS

53
Q

Neisseria menigitidis

Outer membrane

A 
Epidemic disease - 2&15
Opa- class 5
RMP- class 4
54
Q

Neisseria menigitidis

Epidemiology

A

Worlwide
Developing countries
Greatest in children younger than 2 years old
Def in C5-8

55
Q

Neisseria menigitidis

Pathogenesis

A

Nasopharynx
Attached to epithelial cell
Bloodstream
Bacteremic spread

Similar to URTI

56
Q

Neisseria menigitidis

Clinical finding

Meningitis

A 
Most common
Abrupt onset
Headache fever
Hearing defects
Arthritis
Brain covered with thick purulent exudate
57
Q

Neisseria menigitidis

Clinical finding

Meningicoccemia

A

Without meningitis
Thrombosis of small blood vessels
Petichial hemorrhages

58
Q

Neisseria menigitidis

Clinical finding

Meningo

A

Water house- friderichsen syndrome

59
Q

Neisseria menigitidis

Diagnosis

A

Ituloy mo na lang

60
Q

Neisseria menigitidis

Diagnosis

Specimens

A

Blood
Spinal fluid
Nasopharyngeal swab
Material from petechiae

61
Q

Neisseria menigitidis

Diagnosis

Smear

A

Smear of spinal fluid or petechiae aspirate

62
Q

Neisseria menigitidis

Diagnosis

Culture

A

Thayer martin media- nasopharyngeal specimen with VCN

63
Q

Neisseria menigitidis

Diagnosis

Culture

A

Blood specimen- without sodium polyanethol sulfonate

Chocolate agar-

64
Q

Neisseria menigitidis

Diagnosis

Serology

A

Latex agglutination

Hamaglutination

65
Q

Neisseria menigitidis

Treatment

DOC

A

Pen G

66
Q

Neisseria menigitidis

Treatment

If allergic to Pen G

A

3rd generation cephalosporin

67
Q

Neisseria menigitidis

Treatment

Chemoprophylaxis

A

Rifampicin

Ciprofloxacin

68
Q

Neisseria menigitidis

Prevention

A

Polyvalent vaccine

Group A,C,y and W135

69
Q

Person with asplenia

A

Decrease defense against encapsulated bacteria

70
Q

Neisseria characteristics

A 
Human pathogens
Fastidious
Aerobic
Gram negative cocci
Coffee bean shape

Microbiology Midterm (2 decks)

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