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Neisseria Gonorrhoea Flashcards

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1
Q

Which is the second commonest bacteria in the UK?

A

Neisseria Gonorrhoea

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2
Q

What makes neisseria Gonorrhoea a major public health concern?

A

It’s antimicrobial resistance.
Its persistence and
Its association with poor reproductive health outcomes.

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3
Q

What are the factors that divide gonococci into 4 kellog types?

A

Colonial appearance.
Ability to auto aggultinate
Virulence.

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4
Q

Name the four kellog types of gonorrhoea.

A

Type 1-4

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5
Q

Name the two kellog types that are more virulent and posses many fimbrae

A

Type 1 and 2

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6
Q

Which kellog is avirulent and non- fimbrate

A

Type 3-4

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7
Q

What’s the fxn of fimbrae on the gonococci

A

It’s aids in attachment in mucosa surfaces.

And confers resistance from phagocytosis.

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8
Q

List the two epidemiological typing used by gonococci:

A

Auxotyping (using nutritional requirements of arginine, proline, hypoxanthine and uracil.et.c) HAPU

Monoclonal antibodies.

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9
Q

List the clinical manifestation of gonococci in males:

A

Acute urethritis accompanied with purulent urethral discharge.

Water can perineum as a secondary complication

Epididymitis

Epididorchitis

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10
Q

What’s the incubation period of gonococcal in males

A

2-7 days.

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11
Q

What is water can perineum?

A

This is abscess and sinus formation in the perineum as a result of gonococcal spread to peri urethral areas.

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12
Q

Is gonococcal more severe in females? +

A

No,
Its asymptomatic in females

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13
Q

List the clinical manifestation of gonococci in females.

A

Mucopurulent cervicitis(most common presentation)

Vulvovaginitis.

Salpingitis

Pelvic inflammatory disease

Fitz Hugh Curtis syndrome

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14
Q

In what age grade is Vulvovaginitis seen in and why?

A

Prepubertal girls.
Post menopausal women.

Reason : due to low oestrogen level.

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15
Q

Why doesn’t Vulvovaginitis affect adult females

A

Because of low vagina pH and
Thick stratified squamous epithelium

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16
Q

Does this clinical manifestation affect the female sterility?

A

Yes.
It leads to sterility.

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17
Q

What is Fitz Hugh Curtis syndrome

A

Perihepatic inflammation

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18
Q

What’s the clinical manifestation of gonococci in neonates?

A

Ophthalmia Neonatorum.

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19
Q

When does purulent eye discharge occur in neonates

A

2-5 days after birth

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20
Q

How does a neonates contact Ophthalmia neonatorum?

A

Through birth via a gonococcal colonised maternal genital flora

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21
Q

Treatment of ophthalmia neonatorum

A

Silver nitrate

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22
Q

List secondary local complications of gonococcal

A

Epididymitis
.
Salpingitis

Metastatic complications like arthritis.

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23
Q

What are the other(tertiary ) manifestations of gonococcal infection.

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A

Disseminated gonococcal infection :

skin lesion, painful joints and fever.

Ophthalmia neonatorum.

Perihepatic inflammation.

And rarely endocarditis and meningitis.

24
Q

How are asymptomatic rectal and pharyngeal infection often identified.

Study These Flashcards
A

Through contact tracing

25
Does gonococcal enhance HIV transmission?
Yes
26
List the microscopic features :
Gram negative, Intracellular, Aerobic, Diplcocci,
27
Mentioned the culture steps of gonococcal investigation.
1. Collect urethral swabs from males and endocervical swabs from females. 2) Innoculate into a selective media and place in a rich CO2 culture.
28
Which is the most sensitive laboratory investigation regimen and why?
NAAT: Nucliec acid amplification test. Detects both symptomatic and asymptomatic infections. 96% more sensitive than culture
29
Which bacteria infxn accompanies gonorrhea infection.
Chlamydia trachomatis
30
Which sample is taken for disseminated gonococcal infection.
Synovial, Blood culture.
31
What's the transport media for gonococcal
Charcoal impregnated swap
32
List the culture media for gonococcal
Chocolate media, Mueller Hinton agar
33
List the selective agar
Thayer- Martins, Modified new York City media. Martin-Lewis media
34
What's the treatment for gonorrhea meningitidis
Ceftriaxone and azithromycin
35
What are the agents for bacteria of non gonococcal urethritis
Chlamydia trachomatis. Ureaplasma urealyticum. Mycoplasma hominis
36
What are the agents for virus of non gonococcal urethritis
Herpesvirus. Cytomegalovirus
37
What is the agent for parasite cause of non gonococcal urethritis
Trichomonas vaginalis
38
What is the fungal cause of non gonococcal urethritis
Candida albicans
39
What's the onset for gonococcal urethritis
48hrs(2days)
40
When is the onset for non gonococcal urethritis
Longer than 1 week
41
What is the features of the discharge in gonococcal urethritis
Purulent(flows like seed)
42
What is the features of the discharge in non gonococcal urethritis?
Mucous to mucopurulent
43
What is the complication of non gonococcal urethritis?
Reiters syndrome : Xterised by Conjunctivitis, urethritis, arthritis and mucosa lesions.
44
What are the common complications in gonococcal and non gonococcal urethritis in MALES:
Epididymitis. Prostatitis.. Seminal vasculitis. Balanitis
45
What are the common complications in gonococcal and non gonococcal urethritis in FEMALES:
Salpingitis, Fitz Hugh Curtis syndrome. Pelvic inflammatory disease.
46
Which culture is used for chlamydia diagnosis :
McCoy and Hela cell lines
47
Which culture is used for trichomonas diagnosis :
Trophozoites
48
Which culture is used for candida diagnosis :
Detection of budding yeast cells in discharge.
49
What is used to diagnose HSV and chlamydia infxn? n
PCR
49
What is used to diagnose HSV and chlamydia infxn? n
PCR
50
Treatment for chlamydia
Doxycycline
51
Treatment for trichomonas
Metronidazole
52
Treatment for candida
Clotrimazole (vagina cream)
53
Where is the habitat of non pathogenic neisseria in the body
Upper respiratory tract(they're commensals there)
54
List the examples of Non pathogenic neisseria.
N. Lactamica N. Mucosa. N. Subflava. N. Flavescens. N. Elongata. N. Sica. N. Cinera. N. Weaveri. N. Polysaccharea
55
Name the occasionally invasive disease of non pathogenic neisseria.
Meningitis, Endocarditis, Bacteriemia Pericarditis, Osteomyelitis. Ocular infections. Empyema.

Bacteriology (10 decks)

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