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Neonatal Flashcards

(109 cards)

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1
Q

What figure constitutes an unconjugated (indirect) jaundice?

A

CB less than 15% of total bilirubin

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2
Q

What figure constitutes a direct/conjugated jaundice?

A

Conjugated bilirubin greater than 15% of total or over 20mmol/L

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3
Q

What constitutes prolonged jaundice in term and preterm babies?

A 
Term = 2 weeks of age plus
Preterm = 3 weeks of age plus
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4
Q

6 areas of causes of conjugated hyperbilirubinaemia?

A 
Sepsis
Extrahepatic biliary obstruction
TPN jaundice
Toxic e.g. Aspirin, paracetamol, rifampicin, alcohol, steroids
Neonatal hepatitis
Metabolic or genetic
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5
Q

What type of jaundice is TPN associated jaundice?

A

Conjugated

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6
Q

6 areas of causes of unconjugated hyperbilirubinaemia?

A

Sepsis
Physiologic e.g. Breast milk
Haemolytic e.g. Rhesus/ABO
RBC defects e.g. G6PD def, hereditary spherocytosis/eliptocytosis or pyruvate kinase deficiency
Conjugation defects - Gilbert’s or Crigler Najjar
Other - galactosaemia, delayed cord clamping, cephalhaematoma/bruising, pyloric stenosis

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7
Q

What type of jaundice does congenital hypothyroidism cause?

A

Conjugated

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8
Q

What type of jaundice is breastfeeding/physiological jaundice?

A

Unconjugated

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9
Q

Why is jaundice more likely in neonates?

A

Increased bilirubin production due to higher haematocrit and higher red cell turnover due to decreased life span (85 days)
Decreased conjugation
Increased enterohepatic circulation due to reduced gut motility

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10
Q

What type is most neonatal jaundice and therefore what is more worrying?

A

Most is unconjugated

So conjugated potentially concerning

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11
Q

What is the typical pattern of physiological jaundice in neonates?

A

Occurs after 24 hours, peaks at 2-4 days and resolves within 1-2 weeks

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12
Q

Why does TPN cause jaundice? Which type?

A

Lower gut motility so increased enterohepatic circulation and increased absorption of conjugated bilirubin into blood

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13
Q

What does early (less than 24 hours after birth) jaundice often reflect?

A

Severe haemolysis e.g. ABO or rhesus
Other red cell or membrane defects
Or severe cephalhaematoma

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14
Q

What is more likely the cause of prolonged jaundice?

A

Infection or metabolic disease incl hypothyroidism

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15
Q

What type of hyperbilirubinaemia is worse for neurological function and can cause acute neonatal encephalopathy?

A

Unconjugated

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16
Q

What is kernicterus?

A

Chronic sequelae of often acute hyperbilirubinaemia (usually unconjugated), consisting of choreoathetoid CP (dyskinetic), SN hearing loss and loss of upgaze plus dental enamel dysplasia

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17
Q

Early to late signs of acute bilirubin encephalopathy?

A

Early hypotonia and high pitched cry
Febrile, poor feeding, lethargic
Later retrocolis, opisthotonos, apnoeas, seizures, hypertonic and death

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18
Q

What type of hyperbilirubinaemia is managed by UV phototherapy and why?

A

Unconjugated - converts unconjugated to water soluble photo-isomers which are then excreted in urine

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19
Q

What cause of unconjugated hyperbilirubinaemia is UV phototherapy often not very effective for?

A

Haemolysis

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20
Q

Side effects and considerations for UV phototherapy for neonatal jaundice?

A

Need to be well hydrated to maintain urine output
Can get eye damage, diarrhoea, skin rash, overheating
Also lack of parental contact

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21
Q

When might exchange transfusions or IVIg be used for hyperbilirubinaemia?

A

If very very high or quick rise

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22
Q

What is NRDS? After what gestation is it rare?

A

Lung disease in newborns due to surfactant deficiency - mostly a disease of the very premature, rare after 32 weeks

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23
Q

Give 4 metabolic disturbances that can inhibit surfactant production?

A

Acidosis
Hypothermia
Hyperglycaemia
Sepsis

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24
Q

How is NRDS prevented?

A

Maternal steroids

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25
What is transient tachypnoea of the newborn TTN? What does it usually present following?
Due to delayed surfactant clearance or absorption of surfactant - commonly in the setting of elective CS
26
How do babies get congenital pneumonia and what bugs therefore usually cause it?
Inhalation of infected amniotic fluid e.g. Chorioamnionitis or maternal illness Usually caused by GBS, E Coli, listeria, chlamydia etc.
27
What are the 3 main pathogenic features of meconium aspiration syndrome?
Mechanical airway blockage Barrier preventing airway exchange Chemical pneumonitis
28
What are exam findings for meconium aspiration syndrome?
Diffuse wet crackles, rhonchi Respiratory acidosis In setting of stained liquor
29
What infection can be related to meconium aspiration syndrome?
Listeriosis
30
What is bronchopulmonary dysplasia? Definition in terms of gestation?
Impaired alveolar development sometimes defined as oxygen requirement after 36 weeks gestation
31
What reduces the incidence of nec?
Breastfeeding
32
4 RFs for nec?
Prematurity VLBW/IUGR causing gut ischaemia Hypoxia Polycythaemia or exchange transfusions
33
What part of the bowel does nec often affect?
Terminal ileum/caecum
34
What structural findings of the bowel characterise nec?
Subserosal gas on mesenteric border of bowel | Gangrenous necrosis on antemesenteric border
35
When does nec generally present? What makes it present later?
Usually presents in 2nd week of life - 8 to 10 days | Can be later in very premature babies
36
Early signs of nec?
Change in feeding tolerance - increased aspirates and gastric retention (residual milk in stomach pre feed) Abdominal distension and vomiting
37
Later progressive signs of nec?
``` General illness and fevers Abdo tenderness Blood stained stool Ileus, perforation Shock, DIC, organ failure ```
38
What does XR show for nec?
Pneumatosis intestinalis and hepatic portal venous gas
39
What criteria is used to stage nec? Briefly outline them?
Bell's staging criteria Stage 1 is suspected nec - non specific illness, early GI signs in predisposed infant, XR shows dilated bowel Stage 2 is definite nec - as above plus mild to moderate acidosis, thrombocytopenia, gross GI bleeding plus gas and thickened wall on XR Stage 3 is advanced nec - shock, severe acidosis, DIC, significant bleeding, pneumoperitoneum etc.
40
What fbc disturbance is common and possibly severe in nec?
Thrombocytopenia
41
Management of nec?
Supportive initially - pass free drainage NG tube Broad spec Abx for 2 weeks Surgery as indicated - beware risk of short bowel syndrome
42
Where does caput succedaneum form and what is it?
Oedematous region forming between skin and galeal aponeurosis/periosteum
43
How can you tell a caput succedaneum?
It crosses suture lines
44
Which neonatal haematoma crosses suture lines?
Caput succedaneum
45
What is a cephalohaematoma and where does it form?
Traumatic subperiosteal bleed just deep to epicranial/galeal aponeurosis
46
How can you tell a cephalohaematoma?
Doesn't cross suture lines
47
Which neonatal haematoma doesn't cross suture lines?
Cephalhaematoma
48
3 risks/possible sequelae of cephalohaematoma?
Unconjugated hyperbilirubinaemia Ossification or calcification and subsequent deformation Infection
49
What is a chignon?
A temporary swelling on baby head following ventouse delivery
50
What is the term for a temporary baby head swelling following ventouse delivery?
Chignon
51
What is a subgaleal haematoma?
Bleed between periosteum and galeal aponeurosis
52
Which is potentially the most serious neonatal haematoma and why?
Subgaleal haematoma | As it can cause large intravascular loss and shock
53
What usually causes a subgaleal haematoma?
Ventouse assisted delivery
54
When is IVH most common and why?
In very premature babies (27-30 weeks or less) | Because blood vessels in brain strengthen over last 10 weeks of gestation
55
What is the natural history/progression of IVH?
Starts as periventricular subependymal germinal matrix (PVH) before extending into lateral ventricles (IVH)
56
Complications of IVH?
Post-haemorrhagic ventricular dilatation (PHVD) - wide cranial sutures Apnoeas Seizures Setting sun eyes
57
What measurement is used to track IVH for PHVD?
Ventricular index/Levine measurement
58
What 2 complications of IVH may lead to risk of cerebral palsy?
Parenchymal infarct | PHVD
59
When does IVH most commonly occur?
First few days of life
60
3 descriptions of bleeding distribution in IVH and how do these relate to grades?
Subependymal only = grade 1 germinal matrix haemorrhage IVH +/- ventricular dilatation IVH +/- parenchymal involvement = grade 4 parenchymal haemorrhage
61
What is periventricular leukomalacia?
Severe haemorrhagic periventricular infarct and HIE can lead to cortical necrosis, basal ganglia injuries, focal infarcts or subcortical leukomalacia High risk of spastic diplegic cerebral palsy
62
What processes typically underlie PVL?
Labile BP e.g. Shock or hypotension
63
What are signs of TOF/OA?
Polyhydramnios in mum Mucousy baby, choking on feeding Unable to pass NG tube - try this then CXR
64
What are the 5 types of TOF/OA by Gross classification?
A - proximal and distal oesophageal buds with missing mid segment, no TOF (long gap OA) B - proximal and distal oesophageal buds, proximal TOF C - proximal OA with distal TOF at carina D - proximal oesophagus terminates at proximal trachea, distal oesophagus arises from lower trachea E - TOF without OA
65
What is H type TOF/OA?
Isolated TOF, no OA
66
What is the most common type of TOF/OA?
C - proximal OA with distal TOF
67
Management of a TOF/OA?
Regular aspiration of proximal oesophageal pouch and IV fluids Urgent surgery if child needs mechanical ventilation
68
Long term sequelae of TOF/OA?
Tracheomalacia, respiratory disease incl early aspiration, oesophageal obstruction when moving to solids, GORD
69
Bilious vomiting in neonates is what until proven otherwise?
Midgut malrotation with volvulus
70
Differentials for bilious vomiting in neonates?
``` Malrotation +/- midgut volvulus Duodenal atresia Jejuno-Ileal atresia Meconium ileus Hirschprungs disease Nec ```
71
How does retinal vasculature develop in foetus and newborn?
Starts developing around 16 weeks duration from optic disc | Finishes vascularising to edge of peripheral retina by around 1m post birth
72
Why does retinopathy of prematurity occur?
Retinal vessels are used to growing in relatively hypoxic conditions, so if born prem the retina becomes hyperoxic which reduces VEGF production This halts vascular growth, vessels vasoconstrict and obliterate Eye continues to grow and periphery becomes hypoxic again, inducing VEGF This leads to angiogenesis of tortuous vessels, fibrovascular prolfieration and intravitreal fibrosis eventually leading to retinal detachment
73
Risk factors for ROP?
LBW/VLBW Born under 32 weeks gestation O2 therapy Respiratory distress and IVH are predictive
74
Describe screening process for ROP?
All babies born at 32 weeks or less or BW less than 1500g 32-27 weeks are screened at 28-35 d of life Less than 27 weeks are screened at 30-31 weeks gest age Then weekly or fortnightly as clinically appropriate
75
Management options for ROP?
Laser photocoagulation/cryotherapy Anti-VEGF for aggressive posterior ROP Vitrectomy or vitreoretinal surgery to reattach detached retina (stage 5)
76
What is stage 5 ROP?
Retrolental fibroplasia - retinal detachment
77
What is the surgical management of biliary atresia and how does this vary?
If completely obstructed requires liver transplant | If incomplete can do Kasai procedure - hepatoportoenterostomy
78
How does biliary atresia present?
'Late' prolonged conjugated jaundice | Eventually progressing to cirrhosis, ascites, liver failure
79
2 alternative names for biliary atresia?
Extrahepatic ductopenia | Progressive obliterative cholangiopathy
80
Investigations for biliary atresia?
Bloods incl deranged LFTs Liver biopsy Imaging incl USS
81
What do they do in a Kasai procedure?
Attach part of small intestine directly to liver | Attach the rest of small intestine (from stomach - proximal end) to this small intestine to form a Roux en Y connection
82
What is the most common cause of congenital/infantile stridor?
Laryngomalacia
83
4 examples of central wall defects?
Ectopia cordis Cloacal exstrophy Exomphalos Gastroschisis
84
Which abdominal wall defect is associated strongly with other syndromes? Which ones?
Exomphalos E.g. Trisomies 13, 18, 21 and other chromosomal Beckwith-Wiedemann Penatology of Cantrell Cloacal exstrophy and other caudal defects
85
Which side does Gastroschisis usually occur on?
Right side
86
When does the diaphragm usually close in gestation?
8 weeks
87
What is the most common type of Congenital Diaphragmatic Hernia?
Bochdalek - postero-lateral CDH which affects back left of diaphragm
88
What are the 5 most important parts of newborn screening?
``` Eyes Ears Heart Hips Testes ```
89
When is newborn check usually done?
Between 6 and 24 hours of birth to give time for nappy changes, feeds, circulatory adaptations etc
90
What is normal feeding amount for an established baby up to around 6m? How often is this split up into?
150ml/kg/day, often starting at around 60ml/kg/day | Split into 3 to 4 hourly feeds
91
How often does breast feeding tend to occur and how long does it last?
Every 2-3 hours lasting 10-20 mins
92
What is the first breast milk called and when does normal breast milk after this come in?
Colostrum | Normal milk comes in around 3 days
93
Normal newborn baby heart rate?
120-160
94
Normal newborn resp rate?
40-60
95
What would you do if suspecting TTN but not cleared by 6 hours?
CXR and start empirical Abx
96
How and when is surfactant given after birth?
At the time of birth when intubation occurs, down the tube | And again at 12 hours if necessary
97
From what gestation can babies normally coordinate oral feeds?
34 weeks
98
How and when is TPN given and how is it weaned?
Normally given pre 32 weeks gestation via UVC Balance with breast milk and reduce TPN over time, giving bolus feeds from 32 weeks and moving on to oral by 34 weeks Aiming for the total of 150-175ml/kg/day
99
How do you confirm a malrotation?
Upper GI contrast
100
When do premature babies have head scans?
1 and 6 weeks of age
101
What is vernix caseosum?
White slimy stuff that covers babies
102
What is erythema toxicum?
Classically white papules with erythematous flare affecting hands, feet, back of trunk etc
103
What are milk spots?
Hypertrophic sebaceous glands often on nose
104
What is witches milk?
Milk that can come from newborn breast tissue due to withdrawal of hormonal flow from placenta
105
What is a simple naevus?
Stork bite (front and back of head)
106
How long does strawberry naevus take to go? When would you decide to treat?
Up to 18m | May treat if on eye or nappy area
107
With what disease is a sunflower cataract associated?
Wilson's disease
108
What might be the cause of later onset neonatal sepsis e.g. On SCBU?
Coagulase negative staph
109
What is the grading system for HIE? What is its role?
Sarnat staging | 1-3 mild to severe, suggests the likelihood of subsequent seizures and prognostication

Y5 Paediatrics (13 decks)

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