Neonatal Complications Flashcards

1
Q

APGAR Score- Predictive?

A
  • Lower APGAR score does not mean the child will have long lasting or long term health problems.
  • It is a score that “follows” you always. It may give the pediatric therapist a window into how life outside the womb began!
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2
Q

Perinatal Care Levels

A
  • Level I: Well Baby Nursery
    • “feed and grow” in small community hospitals
    • Stabilize ill newborns until transfer to higher level care
  • Level II: Special Care Nursery
    • physiologic immaturity and moderate illness in infants ≥32
    • weeks and 1500 grams, mechanical ventilation for <24 hours
    • Convalescence after intensive care
    • Stabilize infants < 32 weeks until transfer to NICU
  • Level III: NICU
    • Provide sustained life support and comprehensive care for
    • infants born ≤ 32 weeks and 1500 grams, mechanical vent.
    • full range of adv. imaging, peds specialists readily available
  • Level IV: Regional NICU
    • located in institution where surgical repair of complex conditions
    • provided and all peds specialists on site
    • Facilitate transport
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3
Q

Asphyxia

A
  • Results from inadequate oxygen and carbon dioxide exchange
  • 1-8/1000 live births
  • 60% of VLBW infants
  • Associated with PVH/IVH in preemies and HIE in term infants
  • Causes hypoxic-ischemic encephalopathy (HIE)
  • Hypoxemia: decreased arterial oxygen concentration – can cause bradycardia which causes ischemia(decrease amt of oxygen circulating in blood)
  • Ischemia: decreased blood flow (glucose) to brain due to systemic hypotension and decreased cardiac output (decrease in blood flow able to perfuse the brain)
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4
Q

HIE

A
  • HIE causes (leads to):
    • Cognitive impairment
    • Muscle tone abnormalities
    • Seizure disorder
  • Classification of severity
    • 1.Mild
    • 2.Moderate
    • 3.Severe
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5
Q

Mild HIE

A
  • Mild HIE: infants require resuscitation
    • Irritable
    • Jittery
    • Normal muscle tone
    • No long term neurological problems
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6
Q

Moderate HIE

A
  • Moderate HIE: infants require resuscitation and need short term assistance with respiration
    • Lethargy
    • Feeding problems
    • Seizures
    • At risk for developmental delay
    • Need PT eval
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7
Q

Severe HIE

A
  • Severe HIE: infants require resuscitation and prolonged mechanical ventilation
    • Severe hypotonia
    • Decreased movement
    • Seizures
    • Majority have developmental delay
    • May have permanent organ damage
    • May cause PVL in premature infants or watershed infarcts in term infants
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8
Q

Periventricular Leukomalacia

(PVL)

A
  • Decreased cerebral blood flow in premature infants results in PVL
  • Bleeding into and around ventricles (white matter) that may form cystic cavities
  • Associated with cognitive and visual impairment
  • Associated with spastic diplegia cerebral palsy {leading known cause of CP}
  • Often associated with IVH
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9
Q

Intraventricular Hemorrhage

(IVH)

A
  • Bleeding into ventricles
  • Most occur within 48 hours after birth (related to fragility of germinal matrix)
  • Most common in premature infants (<32 weeks GA)
  • Occurs in 45% of preemies weighing 500-750 grams and in 20% of those <1500g
  • The lower the birth weight and the more complications, the greater the risk of IVH
  • At increased risk if born with
  • unstable respiratory status
  • breech presentation
  • difficult delivery
  • Swings in blood pressure cause ischemia that causes IVH
  • Detectable with cranial ultrasound through fontanelles
  • Neurologic outcome correlated to severity of IVH
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10
Q

Grades of IVH

A

I: isolated germinal matrix hemorrhage

II: IVH in only 10-15% of area and no enlargement of ventricles

III: IVH in >50% of area with dilated ventricles

IV: IVH with dilation and spread into the periventricular white matter

***

  • Grades I and II:* minimal risk for long term neuro deficits
  • Grades III and IV:* significant risk for long-term neuro deficits including hydrocephalus (requiring shunt), CP, cognitive impairment
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11
Q

IVH Signs & Symptoms

A
  • Changes in level of consciousness
  • Changes in muscle tone
  • Changes in movement
  • Changes in respiratory function
  • Changes in eye movement

TO

  • Stupor à coma
  • Respiratory distress à apnea
  • Seizures
  • Decerebrate posturing
  • Flaccid quadriplegia
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12
Q

PVL & IVH

A
  • Vergani et al’s 2004 study indicates that spontaneous prematurity and GA predict up to 2/3s of PVL & IVH
  • PVL causes greater degree of developmental delay than IVH
  • PVL believed to occur due to too little cerebral blood flow (ischemia) vs too much cerebral blood flow (high BP) with IVH
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13
Q

Preeclampsia:

A
  • maternal condition 20-40 weeks gestation and 1 week post-partum that results in development of maternal hypertension or edema; can lead to eclampsia
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14
Q

Eclampsia:

A
  • maternal condition arising from uncontrolled or undetected preeclampsia resulting in a stroke, coma, or convulsion
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15
Q

ECMO:

A
  • extracorporeal membrane oxygenation; used in infants or young children who have very poor cardiopulmonary status – buy time for healing or transplant
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16
Q

Meconium aspiration

A
  • meconium (1st stool) passed in utero and ingested by infant with 1st breath
    • Causes airway obstruction and results in respiratory distress syndrome
17
Q

Respiratory Distress Syndrome

A
  • RDS also called hyaline membrane disease (HMD)
  • Most common single cause of death and illness in preemies (50-60% if <29 wks)
  • Results from insufficient surfactant in preemies
  • Surfactant develops >35 (32) weeks GA (corticosteroids induce surfactant synthesis to help ready lungs for birth)
  • Sufficient levels of surfactant at 37-38 weeks GA
18
Q

Clinical signs of RDS

A
  • Grunting respirations
  • Retractions
  • Nasal flaring
  • cyanosis
  • If persists for several months, can result in bronchopulmonary dysplasia (BPD)
19
Q

bronchopulmonary dysplasia (BPD)

A
  • Lower gestational age
  • Mechanical ventilation still on day 7 (lung injury due to mechanical injury)
  • Over-reactive airways
  • Lung fluid retention
  • Oxygenation defect
20
Q

BPD characterized by…

A
  • Destruction of cilia in respiratory tract
  • Necrosis of respiratory epithelial cells
  • Pulmonary fibrosis occurs due to scar formation from healing

***Often associated with neurological deficits due to impaired oxygenation

21
Q

Chronic lung disease (CLD)

A
  • Believed to occur due to
    • Barotrauma associated with mechanical ventilation
    • Elevated concentrations of oxygen
    • Endotracheal tube intubation
22
Q

Retinopathy of Prematurity

A
  • ROP occurs in preemies due to incomplete growth of retinal blood vessels after birth→hypoxia→ growth of new blood vessels that are fragile and can leak→scar retina→detach retina
  • More common in LBW infants, lower GA, and BPD
  • Graded from I-V (mildest-most severe)
23
Q

ROP treatment

A
  • May be treated with cryotherapy or laser therapy to arrest progression
  • May result in
    • Nearsightedness
    • Strabismus
    • Scarring of retina
    • Retinal detachment
    • Cortical visual impairment
    • Blindness
24
Q

Gastroesophageal Reflux

A
  • GER or GER(D)?
  • relaxation of lower esophageal sphincter
  • Elevation of infant to at least 30 degrees for at least 30 minutes after a feed
  • Left side-lying effective
25
Q

Hyperbilirubinemia

A
  • Definition: excessive amount of bilirubin in blood
  • Bilirubin is byproduct of hemoglobin in red blood cells (excessive due to pregnancy)
  • Physiologic jaundice – treated with UV
  • Seen in preemies with immature hepatic function
  • If untreated, can result in kernicterus that causes brain damage to basal ganglia, etc. that causes athetosis
26
Q

Necrotizing Entercolitis (NEC)

A
  • Pathologic condition – acute inflammatory disease of the bowel
  • Occurs in 1st 6 weeks post-partum in infants who weigh <2000 grams
  • Occurs in infants who have asphyxia, hypoxia, respiratory distress; impaired blood flow to intestineàmucosal cell deathàinvasion of gas-forming bacteria
27
Q

NEC Signs & Symptoms

A
  • Vomiting
  • Abdominal distension
  • Increased gastric ascites
  • Bloody stools
  • No stools
  • Lethargy
  • Decreased urine output
  • Respiratory alterations