Neonatology Flashcards
(37 cards)
Whom does respiratory distress syndrome affect
Mainly premature neonates, commonly before 32 weeks
What causes respiratory distress syndrome
Lungs haven’t started producing adequate surfactant yet (type 2 pneumocytes) . Leading to high surface tension within alveoli. Leads to lung collapse, as more difficult for alveoli and lungs to expand.
Presentation of RDS
- Tachypnoea (>60 breaths/min)
- Labored breathing, chest wall recession, nasal flaring
- cyanosis
- hypoxia, hypercapnia
Mx of RDS
- Antenatal corticosteroids - dexamethasone to mothers with suspected or confirmed pre term.
- intubation + ventilation
- endotracheal surfactant, artificial surfactant
Definition of bronchopulmonary dysplasia
CHRONIC LUNG DISEASE
- oxygen dependence at 36 weeks of corrected gestational age (gestational age + postnatal age)
Whos mostly affected by bronchopulmonary dysplasia
premature birth babies (usually 23-28 week) and low birth weight
Presentation of bronchopulmonary dysplasia
Baby that needs ventilation/CPAP/supplementary O2 at and passed 36 weeks of postmenstrual age
- Most have initial RDS and then depend on O2
- Many babies continue to have tachypnoea + signs of resp. distress (intercostal recession, nasal flaring), wheezing
Ix for bronchopulmonary dysplasia
CXR, ABG - acidosis, hypercapnia, hypoxia
Mx of bronchopulmonary dysplasia
Resp support - intubation/ventilation, CPAP, O2
Medicine - dexamethosone, diuretics
Complications of bronchopulmonary dysplasia
Developmental delay, hospital readmission, risk of infection
Why is physiological jaundice common in neonates
- Marked release of haemoglobin due to high RBC no.s (hypoxic intrauterine environment)
- red cell life span is shorter in newborn infants
- hepatic bilirubin metabolism is less efficient in first few days of life
What 2 things need to be wary of with neonatal jaundice
- May be sign of another disorder e.g. haemolytic anaemia, infection, metabolic or liver disease
- Unconjugated bilirubin (=fat soluble + can stick to cells) can be deposited in brain, particularly basal ganglia causing kernicterus.
What is Kernicterus
Deposition of unconjugated bilirubin in basal ganglia and brainstem. Bilirubin is fat soluble so can cross bbb.
Px: can vary; lethargy, poor feeding, irritability, increased muscle tone, seizures, coma.
Causes of increased production of bilirubin
- physiological
- haemolytic disease of newborn
- ABO incompatibility
- G6PD deficiency
- sepsis + DIC
- heammorhage
- polycythemia
- normal urine (unconjugated bilirubinaemia insoluble in water)
Causes of Decreased clearance of bilirubin:
- Prematurity (liver development)
- Neonatal cholestasis
- Extrahepatic biliary atresia
- Endocrine disorders (hypothyroid and hypopituitary)
- Gilbert syndrome
- Pale stools (bilirubin not excreted in faeces) + dark urine (bilirubin principally excreted by kidneys)
What time frame is neonatal jaundice considered pathological or physiologocial
- first 24 hours of life = pathological - neonatal sepsis common cause.
- 2-14 days = physiological in full term
- 2-21 days = physiological in premature
Why is jaundice exaggerated in premature neonates
immature liver - increases risk of kernicterus.
Ix for neonatal jaundice
- FBC + blood film: polycythaemia (high RBC/haematocrit) or anaemia (low RBC, Hb)
- Conjugated bilirubin: high indicate hepatobilliary cause
- Unconjugated: high = increased production of bilirubin
- G6PD levels for deficiency
- Blood type testing: ABO incompatibility
- Thyroid function: hypothyroid
Mx of neonatal jaundice
- Total bilirubin levels plotted on treatment threshold charts
- phototherapy (breaks down unconjugated bilirubin so can be excreted into bile and urine)
Common Causes of jaundice in baby less than 24 hours
ALWAYS ABNORMAL
- rhesus hemolytic disease (mum is rhesus negative, baby is rhesus positive)
- ABO incompatibility (mother is type O and baby is type A or B. Mum can develop anti B or anti A antibodies. Coombs test to diagnose)
- G6PD def.
- Hereditary spherocytosis
Common causes of jaundice in baby 2-14 days
- Physiological (HbF lifespan + liver immaturity)
- Breastmilk jaundice (feeding difficulties, dehydration, impaired bilirubin elimination)
- Infection
- Can be exacerbated by bruising and polycythaemia
Common causes of jaundice in baby older than 2 weeks
- Breast milk jaundice
- Congenital hypothyroidism (slows everything down including bilirubin excretion)
- Cystic fibrosis
- Biliary atresia (surgery improves outcomes, failure of biliary tree development).
Why does meconium aspiration occur
- meconium (dark green, sticky faecal material) is usually released from the bowels after birth (within 48hrs)
- in some pregnancies baby can pass meconium in utero, and aspirate the meconium amniotic fluid
What is presentation of meconium aspiration
- Respiratory distress, can be life threatening: tachypnoea, tachycardia, cyanosis, nasal flaring, intercostal recession, gasping or unable to breath
