Neoplasia

Question 1

Difference between conventional ameloblastoma and canine acanthomatous ameloblastoma; locations?

Answer 1

Conventional ameloblastoma has stellate reticulum, CAA does not; CA on maxilla, CAA on rostral mandible

Question 2

Difference between CA/CAA and odontoameloblastoma?

Answer 2

ODA is inductive- has majority OE with SR, but also has PDL-like stroma pulp ectomesenchyme, enamel, and dentin

Question 3

Virus associated with hepatocellular carcinoma? In what species?

Answer 3

Hepadnaviridae (dsDNA); woodchuck, NHPs

Question 4

Where does hepadnavirus integrate?

Answer 4

c-myc or n-myc2 locus

Question 5

Key histo for hepatocellular carcinoma

Answer 5

Trabecular most common, pseudoglandular (adenoid), solid

Question 6

IHC for hepatocellular carcinoma

Answer 6

HepPar1

Question 7

Difference between cutaneous mast cell tumors and GI mast cell tumors; IHC

Answer 7

Mucosal origin, lack IgE and chymase, less histamine (less ulcers); cKIT (CD117)

Question 8

Where are GI mast cell tumors most common

Answer 8

Stomach

Question 9

Key histo for GI mast cell tumors

Answer 9

Poorly staining granules, 33% of feline GI mast cell tumors do not stain with cKIT

Question 10

Who gets GI adenocarcinoma? Where?

Answer 10

Rhesus- ileocecal and colon
Cotton-topped tamarins- colon

Question 11

Why do cotton topped tamarins get colonic adenocarcinoma?

Answer 11

Sequelae to ulcerative colitis

Question 12

Characteristic gross appearance of GI adenocarcinoma

Answer 12

Annular ring-like thickening

Question 13

Most common histologic appearance of GI adenocarcinoma?

Answer 13

Scirrhous and mucin producing
Tubular/acinar
Anaplastic
Signet rings

Question 14

Four main morphologic patterns of pancreatic adenocarcinoma

Answer 14

Small tubular**, large tubular, acinar, hyalinizing

Question 15

What is pancreatic adenocarcinoma associated with?

Answer 15

Diabetes mellitus, nitrosamines, pancreatitis

Question 16

What paraneoplastic syndrome is associated with pancreatic adenocarcinoma?

Answer 16

In cats, paraneoplastic alopecia

Question 17

Who is predisposed to AGASACA?

Answer 17

Old intact female or neutered male dogs

Question 18

What paraneoplastic syndrome with AGASACA

Answer 18

Paraneoplastic hypercalcemia caused by PTHrp

Question 19

IHC profile for AGASACA

Answer 19

CK7, BCL-2 positive
CK14 negative

Question 20

Syndrome associated with carcinoids

Answer 20

Zollinger-Ellison syndrome- secrete gastrin, cause gastric hypersecretion and ulceration

Question 21

How to diagnose carcinoids

Answer 21

Neurosecretory granules on TEM
IHC- synaptophysin, NSE, CgA

Question 22

Most common gastric tumor in the horse? What is it associated with?

Answer 22

Squamous cell carcinoma; EcPV2

Question 23

Most common oral tumor in cats?

Answer 23

Squamous cell carcinoma

Question 24

Clin path findings with SCC

Answer 24

Hypercalcemia, anemia, hypoalbuminemia

Question 25

What is SCC associated with in snakes and turtles?

Answer 25

Herpesvirus

Question 26

What is cholangiocarcinoma associated with? Classic gross appearance?

Answer 26

Flukes; umbilicated

Question 27

Positive IHCs for cholangiocarcinoma

Answer 27

CK7, CK14, CK19

Question 28

What causes choanal papilloma in parrots and macaws? Cholangiocarcinoma?

Answer 28

Psittacid herpesvirus (PsHV) 1, 2, 3; herpesvirus 1

Question 29

In which species is salivary adenocarcinoma more aggressive? Which glands?

Answer 29

Cats; Parotid and submandibular

Question 30

Stains for mucus

Answer 30

Mucicarmine, Alcian blue, PAS

Question 31

Who gets salivary gland myoepitheliomas? Which glands?

Answer 31

BALB mice; Submaxillary and parotid salivary glands

Question 32

What other findings are observed with salivary gland myoepithelioma in mice?

Answer 32

Myeloid hyperplasia of bone marrow and spleen

Question 33

What type of organism is Eimeria tenella/macusaniensis? EM findings?

Answer 33

Apicomplexan protozoan; conoid, micronemes, rhoptries

Question 34

Most pathogenic Eimeria in chickens? Location? Camelids? Location?

Answer 34

Eimeria tenella; cecum Eimeria macusansiensis; jejunum/ileum

Question 35

Key gross with Eimeria tenella; key histo

Answer 35

Fibrinonecrotic cecal core; Fibrinonecrotic typhlocolitis, villous atrophy, erosion; oocysts, schizonts with merozoites, macrogamonts, microgamonts

Question 36

EImeria stiedae affects which species? Location?

Answer 36

Weanling rabbits; bile duct epithelium

Question 37

Key histo with Eimeria stiedae?

Answer 37

Biliary hyperplasia, dilated bile ducts, gametocytes, schizonts, and oocysts in ducts