Neoplasia

Question 1

Neoplasia

Answer 1

New uncontrolled growth
Independent of physiologicalcal growth signal

Question 2

Benign tumors
Malignant tumors

Answer 2

Dont spread or invade distally well circumcized with a capsule; do not metastasize
No well defined dimarcation locally invasive irregular borders no capsule capacity to invade and metasitize

Question 3

Blood vessels
Brain

Answer 3

Benign: Hemangioma
Malignant: Angiosarcoma

Meningioma
Invasive meningioma

Mesothiolioma

Question 4

All tumors are?
Parenchyma

Answer 4

Monoclonal; One type of cell proliferating and dividing eg kappa or lamda genes
G6PD isozyme studies and HUMARA (most common)
Neoplasm that forms the parenchyma

Question 5

Hemartoma
Choristoma
Anaplasia

Answer 5

Normal tissue at normal location but the proportion is wrong egs
Ectopic tissue: adrenal below the kidney

Question 6

Malignant Atypical

Answer 6

Pleomorphism - variation
Hyperchromasia - more dense color excess dna
Nuclear/cytoplasm ratio larger
Irregular

Question 7

Morphology

Answer 7

Solid
Cyst: has cavitary
Papilloma - fingerlike
Polyp - club shapped in a hollow organ
Sessile without distinct stalk easier to become malignant
Pedunculated stalked polyp

Question 8

Benign
Malignant

Answer 8

Malignant are atypical more mitosis
Benign: “oma”
Benign has less mitosis

Question 9

Adenoma

Answer 9

Tumors originating from glands

Question 10

Papilloma
Hemartoma
Choristoma

Answer 10

Benign
** cells normally found at that given site **
** that is not normal to that site **
Arrows in leiomyosarcoma are showing mitosis

Question 11

Dysplasia

Answer 11

Dysplasia = “disordered growth” is a feature of dysplasia along with atypia
*** Dysplasia implies atypia is present (hamartoma = no atypia)
Things are starting to go wrong, but not complete!!

Question 12

Salivary glands

Answer 12

More than one neoplastic layer
2 morphological patterns