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Pathology-Neoplasia > Neoplasia > Flashcards

Neoplasia Flashcards

(64 cards)

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1
Q

CML associated oncogene

A

abl (tyrosine kinase)

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2
Q

c-myc oncogene associated with what tumor

A

Burkitt’s lymphoma

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3
Q

bcl-2 is associated with what tumor

A

Follicular or undifferentiated lymphomas

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4
Q

Gene product of bcl-2

A

anti-apoptotic molecule

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5
Q

HER2/neu associated tumors

A

Breast, ovarian, gastric carcinomas

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6
Q

Mutation causes increased cancer risk with oncogenes by doing what?

A

Increasing their activity; Gain-of-function

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7
Q

ras associated tumor

A

colon carcinoma

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8
Q

GTPase is the gene product of this oncogene

A

ras

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9
Q

_-myc always produces what type of gene product

A

transcription factor

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10
Q

L-myc associated tumor

A

Lung tumor

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11
Q

N-myc associated tumor

A

Neuroblastoma

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12
Q

MEN 2A and 2B associated with what oncogene

A

ret

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13
Q

Gene product of ret

A

tyrosine kinase

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14
Q

Gastrointestinal stromal tumor (GIST) oncogene

A

c-kit

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15
Q

c-kit gene product

A

Cytokine receptor

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16
Q

Retinoblastoma, osteosarcoma associated with what tumor suppressor

A

Rb

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17
Q

Gene product of Rb

A

Inhibits E2F; blocks transition from G1 to S-phase in cell cycle

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18
Q

p53 associated tumors

A

Most cancers, Li-Fraumeni syndrome

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19
Q

Gene product of p53

A

Transcription factor for p21; blocks transition of G1 to S phase in cell cycle

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20
Q

BRCA1/2 associated tumors

A

Breast and ovarian cancers

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21
Q

Gene product of BRCA1 and BRCA2

A

DNA repair protein

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22
Q

Melanoma associated genes

A

p16 (tumor suppressor) and BRAF (protoncogene)

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23
Q

Colorectal cancer (FAP) tumor suppressor

A

APC

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24
Q

WT1 tumor suppressor associated with what tumor

A

Wilms’ Tumor (nephroblastoma)

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25
Neufibromatosis 1 and 2 are associated with what tumor suppressors
NF1 and NF2 respectively
26
RAS GTPase activating protein (RAS-GAP) is the product of what gene
NF1
27
NF2 gene product
Merlin (schwannomin) protein
28
Pancreatic cancer is associated with what tumor suppressor
DPC4 (Deleted in Pancreatic Cancer)
29
DCC tumor suppressor associated with what tumor
Colon cancer (Deleted in Colon Cancer)
30
CarcinoEmbryonic Antigen (CEA) associated with what tumors
Colorectal and pancreatic mostly
31
alpha-fetoprotein associated with what tumors
HCC and nonseminomatous germ cell tumors
32
Hydatidiformmoles and chorocarcinomas associated with what tumor marker
beta-hCG
33
CA-124 tumor marker associated with what cancer
Ovarian cancer
34
S-100 tumor marker associated tumors
Melanoma, neural tumors, schwannomas
35
Tumor marker in metasteses to bone, liver, Paget dx of bone
Alkaline phosphotase
36
Bombesin is the tumor marker associated with these tumors
Neuroblastoma, gastric and lung cancer
37
Hairy cell leukemia (B-cell) tumor marker
Tartrate-resistant Acid Phosphotase (TRAP)
38
Tumor marker in pancreatic adenocarcinoma
CA-19-9
39
Calcitonin is the tumor marker in what tumor
Medullary thyroid carcinoma
40
EBV associated cancers
Burkitt's lymphoma, Hodgkin lymphoma, CNS lymphoma (immunocompromised patients), nasopharygneal carcinoma
41
HPV associated cancers
Cerivical carcinoma (16 and 18), penile/anal carcinoma, upper respiratory SCC
42
Gastric adenocarcinoma and lymphoma associated with what microbe
H. pylori
43
Schistosoma haematobium associated with what cancer
Bladder cancer (squamous cell)
44
Cholangiocarcinoma associated with what microbe
Liver fluke (Chlonorchis sinensis)
45
Aflatoxin (from aspergillus) associated with what cancer
HCC
46
Angiosarcoma in liver associated with what toxin
Vinyl chloride
47
Carbon tetrachloride can cause what
Centrilobular necrosis and fatty change in the liver via free radical injury
48
Smoked foods associated with what type of cancer
Gastric cancer (smoke foods contain nitrosamines)
49
Smoking can cause what cancers
Squamous cell carcinoma (esophagus), squamous and small cell carcinoma (lung), renal cell carcinoma, transitional cell carcinoma (bladder), pancreatic adenocarcinoma
50
Asbestos can lead to what cancers
Bronchogenic carcinoma, mesothelioma
51
Arsenic can cause what cancers
Squamous cell carcinoma (skin), angiosarcoma (liver)
52
Alkylating agents can lead to what cancers
Leukemia
53
Napthalene (aniline) dyes can cause what cancer
Transitional cell carcinoma (Bladder)
54
Cushing syndrome associated with what paraneoplastic neoplasm
Small cell lung carcinoma
55
SIADH associated tumors
Small cell lung carcinoma, intracranial neoplasms
56
PTHrP associated neoplasms
Squamous cell lung carcinoma, renal cell carcinoma, breast cancer
57
Vit D3 associated tumors
Hodgkin's lymphoma and some non-hodgkins lymphomas
58
Erythropoietin associated tumors
Renal cell carcinoma, hemangioblastoma, HCC, pheochromocytoma
59
Antibodies to presynaptic Ca2+ channels at NMJ (Lambert-Eaton syndrome)
Small cell lung carcinoma
60
Most likely primary tumor causing metastases to the brain
Lung
61
Most likely primary tumor causing metastases to the liver
Colon(then stomach, then pancreas) | Think GI sites
62
After regional lymph nodes, what organs are the most common sites of metastasis
Liver and lung
63
Most common primary tumors that metastasize to bone
Prostate, breast
64
Route of metastasis from prostate to bone
Prostatic venous plexus

Pathology-Neoplasia (1 decks)

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