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Pathology-Neoplasia > Neoplasia > Flashcards

Neoplasia Flashcards

1
Q

CML associated oncogene

A

abl (tyrosine kinase)

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2
Q

c-myc oncogene associated with what tumor

A

Burkitt’s lymphoma

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3
Q

bcl-2 is associated with what tumor

A

Follicular or undifferentiated lymphomas

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4
Q

Gene product of bcl-2

A

anti-apoptotic molecule

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5
Q

HER2/neu associated tumors

A

Breast, ovarian, gastric carcinomas

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6
Q

Mutation causes increased cancer risk with oncogenes by doing what?

A

Increasing their activity; Gain-of-function

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7
Q

ras associated tumor

A

colon carcinoma

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8
Q

GTPase is the gene product of this oncogene

A

ras

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9
Q

_-myc always produces what type of gene product

A

transcription factor

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10
Q

L-myc associated tumor

A

Lung tumor

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11
Q

N-myc associated tumor

A

Neuroblastoma

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12
Q

MEN 2A and 2B associated with what oncogene

A

ret

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13
Q

Gene product of ret

A

tyrosine kinase

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14
Q

Gastrointestinal stromal tumor (GIST) oncogene

A

c-kit

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15
Q

c-kit gene product

A

Cytokine receptor

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16
Q

Retinoblastoma, osteosarcoma associated with what tumor suppressor

A

Rb

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17
Q

Gene product of Rb

A

Inhibits E2F; blocks transition from G1 to S-phase in cell cycle

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18
Q

p53 associated tumors

A

Most cancers, Li-Fraumeni syndrome

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19
Q

Gene product of p53

A

Transcription factor for p21; blocks transition of G1 to S phase in cell cycle

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20
Q

BRCA1/2 associated tumors

A

Breast and ovarian cancers

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21
Q

Gene product of BRCA1 and BRCA2

A

DNA repair protein

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22
Q

Melanoma associated genes

A

p16 (tumor suppressor) and BRAF (protoncogene)

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23
Q

Colorectal cancer (FAP) tumor suppressor

A

APC

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24
Q

WT1 tumor suppressor associated with what tumor

A

Wilms’ Tumor (nephroblastoma)

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25
Q

Neufibromatosis 1 and 2 are associated with what tumor suppressors

A

NF1 and NF2 respectively

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26
Q

RAS GTPase activating protein (RAS-GAP) is the product of what gene

A

NF1

27
Q

NF2 gene product

A

Merlin (schwannomin) protein

28
Q

Pancreatic cancer is associated with what tumor suppressor

A

DPC4 (Deleted in Pancreatic Cancer)

29
Q

DCC tumor suppressor associated with what tumor

A

Colon cancer (Deleted in Colon Cancer)

30
Q

CarcinoEmbryonic Antigen (CEA) associated with what tumors

A

Colorectal and pancreatic mostly

31
Q

alpha-fetoprotein associated with what tumors

A

HCC and nonseminomatous germ cell tumors

32
Q

Hydatidiformmoles and chorocarcinomas associated with what tumor marker

A

beta-hCG

33
Q

CA-124 tumor marker associated with what cancer

A

Ovarian cancer

34
Q

S-100 tumor marker associated tumors

A

Melanoma, neural tumors, schwannomas

35
Q

Tumor marker in metasteses to bone, liver, Paget dx of bone

A

Alkaline phosphotase

36
Q

Bombesin is the tumor marker associated with these tumors

A

Neuroblastoma, gastric and lung cancer

37
Q

Hairy cell leukemia (B-cell) tumor marker

A

Tartrate-resistant Acid Phosphotase (TRAP)

38
Q

Tumor marker in pancreatic adenocarcinoma

A

CA-19-9

39
Q

Calcitonin is the tumor marker in what tumor

A

Medullary thyroid carcinoma

40
Q

EBV associated cancers

A

Burkitt’s lymphoma, Hodgkin lymphoma, CNS lymphoma (immunocompromised patients), nasopharygneal carcinoma

41
Q

HPV associated cancers

A

Cerivical carcinoma (16 and 18), penile/anal carcinoma, upper respiratory SCC

42
Q

Gastric adenocarcinoma and lymphoma associated with what microbe

A

H. pylori

43
Q

Schistosoma haematobium associated with what cancer

A

Bladder cancer (squamous cell)

44
Q

Cholangiocarcinoma associated with what microbe

A

Liver fluke (Chlonorchis sinensis)

45
Q

Aflatoxin (from aspergillus) associated with what cancer

A

HCC

46
Q

Angiosarcoma in liver associated with what toxin

A

Vinyl chloride

47
Q

Carbon tetrachloride can cause what

A

Centrilobular necrosis and fatty change in the liver via free radical injury

48
Q

Smoked foods associated with what type of cancer

A

Gastric cancer (smoke foods contain nitrosamines)

49
Q

Smoking can cause what cancers

A

Squamous cell carcinoma (esophagus), squamous and small cell carcinoma (lung), renal cell carcinoma, transitional cell carcinoma (bladder), pancreatic adenocarcinoma

50
Q

Asbestos can lead to what cancers

A

Bronchogenic carcinoma, mesothelioma

51
Q

Arsenic can cause what cancers

A

Squamous cell carcinoma (skin), angiosarcoma (liver)

52
Q

Alkylating agents can lead to what cancers

A

Leukemia

53
Q

Napthalene (aniline) dyes can cause what cancer

A

Transitional cell carcinoma (Bladder)

54
Q

Cushing syndrome associated with what paraneoplastic neoplasm

A

Small cell lung carcinoma

55
Q

SIADH associated tumors

A

Small cell lung carcinoma, intracranial neoplasms

56
Q

PTHrP associated neoplasms

A

Squamous cell lung carcinoma, renal cell carcinoma, breast cancer

57
Q

Vit D3 associated tumors

A

Hodgkin’s lymphoma and some non-hodgkins lymphomas

58
Q

Erythropoietin associated tumors

A

Renal cell carcinoma, hemangioblastoma, HCC, pheochromocytoma

59
Q

Antibodies to presynaptic Ca2+ channels at NMJ (Lambert-Eaton syndrome)

A

Small cell lung carcinoma

60
Q

Most likely primary tumor causing metastases to the brain

A

Lung

61
Q

Most likely primary tumor causing metastases to the liver

A

Colon(then stomach, then pancreas)

Think GI sites

62
Q

After regional lymph nodes, what organs are the most common sites of metastasis

A

Liver and lung

63
Q

Most common primary tumors that metastasize to bone

A

Prostate, breast

64
Q

Route of metastasis from prostate to bone

A

Prostatic venous plexus

Pathology-Neoplasia (1 decks)

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