Neoplasia

Question 1

The malignant counterpart of ovarian dermoid cyst is termed as:

a) Dermatofibroma
b) Cystadenoma
c) choriocarcinoma
d) immature teratoma

Answer 1

D

Question 2

The single most common abnormality in dominant oncogene of tumors in humans in the point mutation in:

a) RAS
b) RET
c) cylin – DI

Answer 2

A

Question 3

In adenoma carcinoma model of colon carcinogenesis, the initial event is:

a) Activation of APC
b) Activation of RAS
c) Loss of tumor suppressor gene on chromosome 18q
d) loss of p53

Answer 3

A

Question 4

Dysregulation in MYC gene occurs in

a) CML
b) Neuroblastoma
c) Burkette

Answer 4

C

Question 5

Reduplication of DNA sequences produced by several changes in the proto-oncogene are exemplified by

a) BCR 2/neu in breast cancer
b) BCR – ABL in chronic myelogenous leukemia
c) Rb in retinoblastoma
d) Bcl2 in follicular lymphoma

Answer 5

A

Question 6

Example of apoptosis gene

a) ras
b) n-myc
c) rb
d) bcl – 2

Answer 6

D

Question 7

Molecular policeman:

a) APC
b) p 53
c) rb gen

Answer 7

B

Question 8

Mesothelioma is strongly associated with exposure to:

a) Arsenic
b) Asbestos
c) Cadmium
d) Vinyl chloride

Answer 8

B

Question 9

What is true of HPV in cervical carcinogenesis

a) Associated with type 16 & 18
b) Genome is non-integrated
c) Aggregation is non-clonal
d) Associated with host proto-oncogene

Answer 9

A

Question 10

A neoplasm associated with Helicobacter pylori

a) Gastric cancer
b) Nasopharyngeal cancer
c) Leukemia
d) Burkitt lymphoma

Answer 10

A

Question 11

What is the most common paraneoplastic condition?

a) Polycythemia
b) Hypercalcemia
c) Hypoglycemia
d) Myesthenia

Answer 11

B

Question 12

True of cancer cachexia

a) loss of ion muscle only
b) caused by nutritional demands of tumor
c) patient’s metabolic rate is reduced
d) effects of cytokines

Answer 12

D

Question 13

Which of the following factors favors the formation and vessels in a tumor?

a) vasculostatin
b) angiostatin
c) thromboxanes
d) beta fibroblast growth factor

Answer 13

D

Question 14

Flow cytometry is helpful in:

a) characterization of leukemia
b) intraoperative consultation
c) diagnosis of cervical cancer
d) Her2/neu protein detection

Answer 14

A

Question 15

A Fetoprotein is a marker for carcinoma of what organ?

a) thyroid
b) liver
c) pancreas
d) stomach

Answer 15

B

Question 16

Tumors will not elicit an immune response

a) no production of tumor antigens
b) activation of immune system by chemical carcinogens
c) decreased cytotoxic T- cell
d) overexpression of HLA Type I

Answer 16

A

Question 17

Which one is a benign neoplasm?

a. Hepatoma
b. Lymphoma
c. Melanoma
d. Adenoma

Answer 17

D

Question 18

Which of the following conditions predisposes to neoplastic formation?

A. Physiologic hypertrophy
B. Physiologic hyperplasia
C. Metaplasia
D. Atrophy

Answer 18

C

Question 19

Which is not an oncogene?

A. Human Papilloma Virus
B. Hepatitis B Virus
C. Herpes Virus
D. Epstein Barr Virus

Answer 19

C

Question 20

Which is not a malignant tumor?

A. Lymphoma
B. Melanoma
C. Leiomyosarcoma
D. Hamartoma

Answer 20

D

Question 21

Leading cause of cancer in men:

A. Skin Cancer
B. Prostate Cancer
C. Lung Cancer
D. Testicular Cancer

Answer 21

B

Question 22

Characteristic of benign tumor

A. Invasive
B. Cohesive
C. Immortal
D. Escape from regulatory control

Answer 22

B

Question 23

Identify which gene is involved. A 45 year old woman has a 2cm mass on her right breast. She has it taken out….pathologist’s results show ductal carcinoma—grade 3. As a resident, they ask you to conduct immunochemistry to
verify.

A. ki-RAS
B. c-src
C. BCR/abl gene
D. c-myc

Answer 23

D

Question 24

All of the following are tumor-suppressor genes except:

A. p53
B. APC
C. Bcl-2
D. NF-1

Answer 24

C

Question 25

Sarcoma is malignant neoplasm of: a. endothelial cell b. epithelial cell c. mesenchymal cell d. NOTA

Answer 25

A

Question 26

A polyp: a. Is not a neoplasm b. Always has a stalk c. Maybe benign or malignant d. Regresses spontaneously

Answer 26

B

Question 27

High incidence of malignancy in both males and females: a. lung b. liver c. spleen d. GI

Answer 27

A

Question 28

In a specimen showing pericarditis, the irregular masses of deeply acidophilic acellular material at the surface of the pericardium are: a. fibrinous exudate b. necrotic debris c. thrombotic material d. granulomatous inflammation

Answer 28

A

Question 29

Dysplasia a. Always proceeds to malignancy b. Is irreversible c. Is disorganized growth of epithelium

Answer 29

C

Question 30

Which characteristic is the hallmark of malignancy? a. Mitotically active cells b. Giant cells c. Paraneoplastic syndrome d. Lymphatic spread

Answer 30

D

Question 31

The Epstein-Barr virus is implicated in which tumor? a. cervical cancer b. hepatocellular carcinoma c. Burkitt lymphoma d. lung cancer

Answer 31

C

Question 32

Most common paraneoplastic syndrome: a. Cushing’s syndrome b. Hypercalcemia c. Myasthenia gravis d. Polycythemia

Answer 32

B

Question 33

The amount of differntiation and/or mitotic activity of a tumor is the basis for: a. tumor nomenclature b. tumor spread c. tumor stage d. tumor grade

Answer 33

D

Question 34

What is the significance of immunohistochemistry? a. cancer screening b. identify mitoses c. quantify DNA d. categorize lymphoma

Answer 34

D

Question 35

Development of hereditary nonpolyposis cancer syndrome requests: a. Evasion of apoptosis b. Loss of tumor suppressing gene c. defect in DNA repair d. Gene amplification

Answer 35

C

Question 36

The most common abnormality of dominant oncogene: a. Ras mutation b. Myc overexpression c. Rb deletion d. p53 loss

Answer 36

A

Question 37

A benign tumor arising from the lymph vessels is properly termed as: a) Lipoma b) Lymphoma c) Lymphangioma d) Lymphangiosarcoma

Answer 37

D