Neoplasia - 5 Flashcards
(20 cards)
Aflatoxin (aspergillus)
Means of exposure/sources
Assoc. cancers
Maize and peanuts
Hepatocellular carcinoma
Arsenic
Means of exposure/sources
Assoc. cancers
Herbicides, vineyard workers, fungicides
Lung cancer, liver angiosarcoma
Benzene
Means of exposure/sources
Assoc. cancers
Component of light oil, used in printing
Acute leukemia, Hodgkin lymphoma
Beryllium
Means of exposure/sources
Assoc. cancers
Space industry materials
Bronchogenic carcinoma
Cyclophosphamide and alanine
Means of exposure/sources
Assoc. cancers
Chemotherapy agent
Trans. cell carcinoma of urinary bladder
beta-napthylamine (aniline dyes)
Means of exposure/sources
Assoc. cancers
Worker in rubber, textile and printing industry
Trans. cell carcinoma of urinary bladder
Polycyclic hydrocarbons
Means of exposure/sources
Assoc. cancers
Chimney sweeper, fish or meats charbroiled on open flame
Squamous cell carcinoma, Adenocarcinoma of distal esophagus
Radon
Means of exposure/sources
Assoc. cancers
By product of uranium decay, and in underground mines
Bronchogenic carcinoma
HTLV-1
Mechanism
Assoc. cancers
Activates TAX gene
T cell leukemia and lymphoma
EBV
Mechanism
Assoc. cancers
Promotes polyclonal B cell prolif. increase risk for t(8;14)
Burkitt’s lymphoma, nasopharyngeal carcinoma
HBV
Mechanism
Assoc. cancers
Activates proto oncogenes, inactivates p53
Hepatocellular carcinoma
HHV-8
Mechanism
Assoc. cancers
Acts via cytokines released from HIV and HSV
Kaposi sarcoma
HPV 16 and 18
Mechanism
Assoc. cancers
16 - E6 inhibits p53; 18 - E7 inhibits RB1
SCC of vulva, vagina, anus, larynx and oropharynx
Bacteria that produces adenocarcinoma and low-grade malignant lymphoma of the stomach
H. pylori
Parasite that produces SCC of the urinary bladder
Schistosoma
Parasite that produces cholangiocarcinoma of bile ducts
Clonorchis sinensis and Opisthorchis
replacement of normal bone marrow by malignant cells and/or fibrosis
Myelophthisic anemia
(IgM) cold agglutinins associated with chronic lymphocytic leukemia (CLL) and certain types of malignant lymphoma
Cold autoimmune hemolytic anemia (AIHA)
a. Activation of this pathway causes degradation of myosin heavy chains in skeletal muscle.
b. what activates it
a. ubiquitin proteasome pathway
b. PIF
LMF functions
- Activates hormone-sensitive lipase (HSL) in adipose cells
- Increases release of TNF from macrophages and monocytes. TNF suppresses the appetite center in the hypothalamus, which leads to weight loss. TNF stimulates apoptosis
