Neoplasia I Flashcards
1
Q
What are tumours?
A
- Abnormal cell growth
- Proliferate and sometimes metastasise
2
Q
What are the two methods of classifying tumours?
A
- Based on cell or origin e.g (non) epithelial tumours
- Based on tumour behaviour e.g benign/malignant
3
Q
Give examples of malignant soft tissue tumours.
A
- OSTEOSARCOMA
- ANGIOSARCOMA
- FIBROSARCOMA
4
Q
Describe benign tumours
A
- Don’t metastasise
- Slower growth than malignant tumours
- Circumscribed
- Ulceration/haemorrhage is less frequent than in malignant tumours
- Well demarcated and well differentiated
5
Q
Compare and contrast the gross appearance of benign and malignant tumours.
A
- Smooth tumour edge compared to irregular edge in malignant tumours
- Malignant tumours will infiltrate adjacent structures
6
Q
Compare and contrast the microscopic features of benign and malignant tumours.
A
- Greater pleomorphism in malignant tumours
- More numerous mitotic figures in malignant tumours
7
Q
What would you look for in gross examinations of tumours?
A
- Size
- Shape
- Number
- Special features
8
Q
Describe tumour morphology.
A
- Tumour adopts various morphological growth patterns e.g polyps, annular, ulcerated, fungating, papillary, sessile
9
Q
Describe tumour grading.
A
- How histologically similar to normal tissue the neoplasm is
- Grade 1: well differentiated
- Grade 2: moderately differentiated
- Grade 3: poorly differentiated
10
Q
Name two ways a Grade 3 tumour might be different from a Grade 1 tumour.
A
- Greater pleomorphism and more frequent mitotic figures
11
Q
What is the difference between carcinoma and sarcoma?
A
- SARCOMA - malignant tumours affecting connective tissue
- CARCINOMA - malignant tumours affecting epithelial tissue
