Neoplasm associations

Question 1

childhood tumor affecting cerebellar hemisphere, optic nerved, hypothalamus

Answer 1

pilocytic astrocytoma

Question 2

Temporal lobe tumor

Answer 2

glanglioglioma

Question 3

kids get this in the lateral ventricle, adults get it in the 4th ventricle

Answer 3

choroid plexus papilloma

Question 4

well circumscribed, non infiltrative cystic tumor of childhood

Answer 4

pilocytic astrocytoma

Question 5

Histo: elongate hair like astrocytes

Answer 5

pilocytic astrocytoma

Question 6

Histo: rosenthal fibers

Answer 6

pilocytic astrocytoma

Question 7

treatment for pilocytic astrocytoma

Answer 7

surgical excision

Question 8

Common genetic mutation of pilocytic astrocytoma

Answer 8

BRAF: KIAA fusion

Question 9

gross: cystic, calcified WHO grade 1 tumor

Answer 9

ganglioglioma

Question 10

Histo: increased number of jumbled, cytologically abnormal neurons mixed into low grade glial background

Answer 10

ganglioglioma

Question 11

histo: mucin and microcysts and calcifications, perivascular non-neoplastic lymphs

Answer 11

ganglioglioma

Question 12

BRAF V600E mutation

Answer 12

some gangliogliomas

Question 13

papillary formation that are abundant, crowded, numbers chorioid plexus cells

Answer 13

choroid plexus papilloma

Question 14

Two types of WHO grade II gliomas

Answer 14

diffuse astrocytoma and oligodendroglioma

Question 15

Diffuse astrocytoma âge group

Answer 15

30s-50s

Question 16

Occurs in the white matter of the cerebral hemisphere

Answer 16

diffuse astrocytoma

Question 17

histo: different astrocyte types, preponderance of fibrillary astrocytes

Answer 17

diffuse astrocytoma

Question 18

IDH1/2 mutation
NO LOH of 1P19q
mutation of p53 or ATRX

Answer 18

diffuse astrocytoma

Question 19

Which has a better prognosis: diffuse astrocytoma or oligodendroglioma?

Answer 19

oligodendroglioma

Question 20

Age group of oligodendroglioma

Answer 20

adults

Question 21

located in cerebral white matter but can infiltrate into the overlying cortex

Answer 21

oligodendroglioma

Question 22

SSx can include seizures

Answer 22

oligodendroglioms

Question 23

histo: chicken wire vascular pattern

Answer 23

oligodendroglioma

Question 24

“fried egg”

Answer 24

oligodendroglioms

Question 25

``` IDH1/2 mutation + LOH of 1p19q + No p53 or ATRX mutation ```

Answer 25

oligodendroglioms

Question 26

tends to occur in ages 0-20 and adults

Answer 26

ependymoma

Question 27

kids get them in the 4th ventricle, adults get them in the spinal cord

Answer 27

epyndymoma

Question 28

most i important prognostic factor of epyndymomas

Answer 28

location, worse in the 4th ventricle compared to the spinal cord

Question 29

Commonly presents with hydrocephalus

Answer 29

eepyndymoma. Also causing hydrocephalus:choroid plexus papilloma

Question 30

Does the his to correlate with the prognosis of anepyndemoma?

Answer 30

no, the location of the tumor does

Question 31

Which has a higher MIB-1 index, an anapestic oligodendrogliooma or a grade II oligodendroglioma

Answer 31

anaplastic oligodendroglioms

Question 32

Age group for anapestic astrocytomas

Answer 32

adult

Question 33

what determines the prognosis for an anapestic astrocytoma?

Answer 33

tumor cell growth rate

Question 34

how does the anapestic astrocytoma differ histologically from the diffuse astrocytoma?

Answer 34

there is an increased mitotic rate

Question 35

histo: enhancement with "fried egg" appearance

Answer 35

anaplastic oligodendroglioma

Question 36

age group for anapestic epyndymomas

Answer 36

kids

Question 37

where do anapestic empyndymomas occur?

Answer 37

4th ventricle

Question 38

What determines prognosis of the anapestic epyndymoma?

Answer 38

it's less about the his to because these tumors tend to recur and can spread distantly through CSF dissemination

Question 39

Most common age group for glioblastomas

Answer 39

50-60s, sometimes kids

Question 40

these tumors look well demarcated but are microscopically infiltrative

Answer 40

glioblastoma

Question 41

histo: nuclear abnormalities, mitotic, microvascular proliferation, and necrosis

Answer 41

WHO grade 4

Question 42

treat with temozolamide

Answer 42

glioblastoma

Question 43

Kids 3-8, especially males

Answer 43

medulloblastoma

Question 44

patternless sheets of small embryonal cells with scant cytoplasm

Answer 44

medulloblastoma

Question 45

small blue cells

Answer 45

medulloblastoma

Question 46

homer wright rosettes

Answer 46

medulloblastoma

Question 47

perivascular pseudorosettes

Answer 47

epyndemoma

Question 48

commonly presents with headache, vomiting, papilledeme, gait disturbance, nystagmus

Answer 48

medulloblastoma

Question 49

prognosis of medulloblastoma

Answer 49

good and responsive the chemo as long as there is no CSF spread