Neoplasm Exam Flashcards
(42 cards)
Define Metastasis
movement of neoplastic cells via the blood, lymphatic or by transplantation to a site more or less remote from the site of origin.
What type of neoplasm does not display metastasis?
benign tumors, malignant neoplasms do.
sarcoma
malignant neoplasm of mesenchymal origin
oma
benign neoplasm of either mesenchymal or epithelial origin
carcinoma
malignant neoplasm of epithelial origin
epithelial neoplasms are derived from which embryonic line?
all: endoderm, mesoderm, ectoderm
mesenchymal neoplasm are derived from which embryonic line?
mesoderm
adenoma
benign epithelial neoplasm of glandular origin
adenocarcinoma
malignant epithelial neoplasm of glandular origin
polyp
benign epithelial tumor arising from mucosal surface, most common in intestine, outward growth
papilloma
benign epithelial tumor arising from cutaneous or mucocutaneous junction, outward growth
Why is lymphoma a “rule breaker”
malignant tumor of the lymphocytes
why is rhabdomyoma a “rule breaker”
benign tumor of striated muscle
what is a teratoma?
benign tumor that involves all 3 germ cell layers
Why is a mast cell tumor a “rule breaker”
mast cell tumor implies both benign and malignant
What is leukemia?
neoplastic cells with bone marrow origin that circulate through the vasculature
what is a multiple myeloma?
malignant plasma cell tumor
mixed tumors have both:
mesenchymal and epithelial cells
The parenchyma is composed of
neoplastic cells
the stroma helps the tumor to achieve what?
providing nutrients to the tumor and it will facilitate growth.
What are the 4 components to the tumor stroma?
- extracellular matrix- proteins and glycoproteins
- fibroblasts- synthesize collagen and ECM components
- vasculature
- inflammatory cells
Name two pro-angiogenic factors
FGF (fibroblast growth factor)
VEGF ( vascular endothelial growth factor)
Name one anti-angiogenic factor
thrombospondin
what is lymphangiogenesis?
sprouts small lymphatic vessels from pre-existing lymphatics from VEGF
