Neoplasms of mature T cells or NK cells

Question 1

Adult T cell leukemia/ lymphoma

Answer 1

Helper T cell
HTLV-1 provirus present in tumor cells
adults with cutaneous lesions, marrow involvement and hypercalcemia, mainly in japan, west africa and caribbean, Agressive

Question 2

Peripheral T cell lymphoma, unspecified

Answer 2

Helper or cytotoxic T cell
no specific chromosomal abnormality
mainly older adults; usualy with lymphadenopath; aggressive

Question 3

Anaplastic Large-cell lymphoma

Answer 3

cytotoxic t cell
rearrangements of ALK
children and young adults, usually with lymph node and soft tissue disease; aggressive

Question 4

extranodal NK/ Tcell lymphoma

Answer 4

NK cell (common) or cytotoxic T cell (rare)
EBV associatd; no specific chromosomal abnormality
adults with destructive extranodal masses most commonly sinonasal aggressive

Question 5

mycosis fungoides/ sezary syndrome

Answer 5

helper t cell
no specific abnormality
adult patients with cutaneous patches, laques, nodules or generalized erythema; indolent

Question 6

large granular lymphocytic leukemia

Answer 6

Cytotoxic T cell and NK cell
No specific chromosomal abnormality
Adult patients with splenomegally, neutropenia and anemia sometimes accompanied with autoimmune disease.