Nephritic Syndrome Flashcards
(28 cards)
What are the triad of nephritic syndrome?
Haematuria
Mild proteinuria
Hypertension
What causes the symptoms?
Inflammation of the glomerulus
- damage to blood flow
- activation of RAAS
- damage to glomerulus
What are other signs of nephritic syndrome?
Increased urea + creatinine
Oliguria
Oedema
What are the effects of glomerular inflammation?
Increased waste products
Low urine output
Fluid retention
What can cause nephritic syndrome?
IgA nephropathy ANCA vasculitis Goodpastures Alport syndrome Post-strep glomerulonephritis
What is IgA nephropathy also known as?
Bergers disease
What is the common presentation of IgA nephropathy?
Haematuria after URTI
What causes the inflammation in IgA nephropathy?
Over production of IgA which forms immune complexes and deposits in renal cells
What is IgA?
Immunglobulin A
Involved in immune response of mucous membranes
What does renal biopsy show in IgA nephropathy?
Mesangial proliferation
What is ANCA vasculitis?
Inflammation of blood vessels associated with ANCA autoantibodies
What are the 2 types of ANCA vasculitis?
C-ANCA (Wegner’s)
P-ANCA (Churg Strauss)
What protein is Wegner’s positive for?
PR3
What protein is Churg Strauss positive for?
MPO
What is Wegner’s syndrome?
Multi-system disorder characterised by necrotizing granulomatous inflammation and vasculitis
What are the common features of Wegner’s?
Sinusitis
Renal failure
Lung disease
What are the tests for Wegner’s?
cANCA
PR3
Urinalysis - proteinuria
How is Wegner’s managed?
Corticosteroids
Cyclophoshamide
What is Churg-Strauss?
Triad of
- asthma
- eosinophilia
- vasculitis
How is Churg-Straus managed?
Steroids
What is Goodpastures?
Acute glomerulonephritis and lung symptoms
What causes the symptoms in Goodpasture’s?
Antiglomerular basement membrane antibodies
What lung symptom is associated with Goodpasture’s?
Haemoptysis
- alveolar haemorrhage due to damage to membrane
How is Goodpasture’s managed?
Treat shock
Immunosuppressive treatment
