nephrolithiasis Flashcards

1
Q

70% of all stones are..

A

calcium oxalate

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2
Q

dehydration is the most common cause of what two stone compositions

A

calcium oxalate
uric acid

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3
Q
  • forms in wide range pH
  • radio-opaque
  • not dissolvable
A

calcium oxalate

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4
Q
  • forms in acidic urine & dissolves w/ urinary alkalinization
  • radiolucent
A

uric acid stones

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5
Q
  • etio: metabolic conditions
  • forms in alkaline urine
  • radio-opaque
A

calcium phosphate

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6
Q
  • etio: UTI
  • forms in alkaline urine
  • radio-opaque
  • dissolves w/ urinary acidification
A

magnesium ammonium phosphate

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7
Q
  • etio: cystinuria (hereditary); forms starting in childhood
  • forms in acidic urine; radio-opaque
  • disolves with alkalinization
A

cysteine stones

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8
Q
  • colic/wave like, sharp flank pain (may radiate to abdomen, testicles/labia)
  • hematuria; N/V; LUTS or asymp. (usually non-obstructing)
A

nephrolithiasis (kidney stones)
obstructing ones usually cause sx secondary to hydronephrosis
intermittent obstruction–> colic

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9
Q
  • fluid in kidneys d/t obstruction anywhere along tract
  • silent or sx
  • can d/t stone, strictures, BOO, BPH, extraureteral compression, trauma, edema, UPJ, clot, reflux
A

hydronephrosis
hydroureteronephrosis?
imaging: IVP (IV pyelogram), KUB, non- con CT flank, etc

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10
Q

tx of nephrolithiasis

A
  1. sx control
  2. surveillance- small nonobstructing renal calculi
  3. dissolution tx- uric acid stone -> urinary alkalinization
  4. medical expulsive therapy
  5. surgical intervention– large ureteral or bladder calculi, refractory small/medium, large non-obstructing
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11
Q

what is medical expulsive therapy

A
  • trial of spontanoeous passage where you try hydration, pain control + alpha blocker or steroids
  • good if its a passable stones, good pain control, no infection, appropriate renal function
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12
Q

what surgical procedure is this

  • gel pad under lower body & fluoroscopy
  • US waves to break up stone +/- stenting
  • C/I: pregnancy, coagulopathy, UTI, renal artery calcifications, AAA, radiolucent stones
  • complications: hematoma, ecchymosis, UTI, pain, steinstrasse, lower stone clearance rate
A

ESWL– extracorporal shockwave lithotripsy

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13
Q
  • option for stone basketing; good for failed ESWL or non-ESWL candidate
  • cystolitholapaxy
  • complications: ureteral perforation, stricture
  • rigid version for ureteral distal stones
  • felxible for failed ESWL, < 2 cm, complex anatomy, proximal stones
A

ureteroscopy w/ laser lithotripsy

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14
Q
  • removes renal calculi from kidney through percutaneous access from back into kidney
  • small hole for large stones
  • disadv: 2-3 day admission, stent or nephrostomy tube
  • uses: large stones over 2.5 cm, failed ESWL, complex anatomy, staghorn stones
  • complications: infxn, pneumo/hemothorax, injury, extravastation of urine, bowel injury
A

PCNL– percutaneous nephrolithotomy

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15
Q

5 indications for emergent tx

A
  • obstructing stone + infection
  • bilateral
  • one kidney
  • refractory pain
  • cannot tolerate oral intake d/t N/V

goal is to drain system via stent & run or nephrostomy tube

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16
Q

5 indications for emergent tx

A
  • obstructing stone + infection
  • bilateral
  • one kidney
  • refractory pain
  • cannot tolerate oral intake d/t N/V

goal is to drain system via stent & run or nephrostomy tube

17
Q

why is it super important to prevent stones

A

if you have it once theres a high chance it will happen again– $$, pain, etc

18
Q

what 4 group of foods should be avoided to help prevent stones

A

high oxalate foods- rhubarb, spinach, tofu, nuts, beans, beets, potatoes/ yams
high sodium
excess fleshy foods
high purines or caclium intake

19
Q

how are calcium stones managed? (4)

A
  • tx hypercalcemia– thiazide diuretics
  • tx hypocitraturia w/ potassium citrate
  • tx hyperuricosuria w/ allopurinol
  • tx cystinuria w/ thiola
20
Q

4 metabolite abnormality seen in urine with calcium stones

A

hypercalcemia, hyperuricosuria
hypocitraturia
cystinuria

21
Q

medication? what should you monitor for? treats what?

  • decreases urinary Ca & corrects acidoses by increasing its reabsorption in proximal & distal tubules
  • inhibits sodium reabsorption in distal tubule
A

thiazides– hypercalciuria
monitor for HYPOkalemia

22
Q

medication? what should you monitor for? treats what?

  • urinary alkalinizer that increases urinay citrate w/ goal pH over 6.5
A

potassium citrate- treats hypocitraturia
monitor for HYPERkalemia (sodium bicarb, baking soda)

23
Q

medication? treats what?

decreases urinary uric acid and works even if normal serum uric acid

A

allopurinol- treats hyperuricemia

24
Q

medication? treats what?

forms bond w/ cysteine to increase its urine solubility

A

thiola– treats cystinuria