Nephropathology Flashcards
filtration of materials from blood into the urine occurs where in the glomerulus?
- glomerular capillaries
is the endothelium fenestrated or non-fenestrated
- fenestrated
what epithelium contains the podocytes
what is also contained there
- visceral epithelial cells
- filtration slits
what happens if there is injury to the capillary wall
- change in architecture
- abnormal filtration of proteins and blood cells
asymptomatic proteinuria is a symptom of
- nephrotic syndrome
asymptomatic hematuria is a symptom of
- Nephritic Syndrome
pathogenesis of crescent formation
- severe inflammation of glomerulus
- focal capillary wall destruction
- blood products (macrophages, fibrin, inflammatory mediators) enter Bowman’s space
- forms parietal epithelial crescent
parietal epithelial crescent indicates
- severe disease
how does pathogenesis of glomerular immune complexes work?
- formation or deposition of Ag-Ab complexes
- complement activation
- AND/OR PMN chemotaxis and activation
- AND/OR mesangial cell proliferation
what is proliferative glomerulonephritis
- extra cells in glomerulus
what is mesangioproliferative glomerulonephritis
- extra mesangial cells
where do immune complexes collect in subepithelial conditions
- layer below podocytes
where do immune complexes collect in subendothelial conditions
- layer above endothelium
there is _____ interstitium in a healthy kidney
- little
___ simple ______ epithelium in PCT
- thick simple cuboidal
