Nepritic syndrome - IgA nephropathy Flashcards Preview

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Flashcards in Nepritic syndrome - IgA nephropathy Deck (11):
1

What is IgA nephropathy?

The deposition of polymeric underglycosylated IgA in the mesangial matrix. (most common nephropathy worldwide)

2

What disease is considered a characteristic form of IgA nephropathy?


Henoch-Schonlein purpura

3

What disease also shows and increase in incidence of IgA nephropathy?


Celiac disease and chronic liver disease who have decreased hepatobiliary clearance.

4

What diseases can IgA nephropathy be secondary to?


1.inflammatory bowel disease
2.psoriasis
3.dermatitis herpetiformis
4.ankylosing spondylitis

5

In what subset of patients is IgA nephropathy most common?

Children and young males

6

In what race is IgA nephropathy most prevalent?

East Asians
May have genetic predisposition or be familial

7

What infections usually trigger IgA nephropathy?

Upper respiratory or gastrointestinal tract infection (mucosal infection).

8

How soon after infection does nephritic urinary sediment occur?

1 or 2 days after infection

9

What are the findings in IgA on immunoflurescence?

Mesangial IgA deposits with C3 and properdin

10

What is the treatment for IgA nephropathy?

1.Steroids
2.ACE inhibitors
3.ARB

11

What are the risk factors for progression to renal failure with IgA nephropathy?

1.Heavy proteiuria
2.Decreased GFR
3.Older age at onset
4.Familial forms of the disease
5.Uncrontrolled hypertension
6.Microscopic features such as crescentic pattern disease, diffuse mesangial proliferation etc