Nervous Tissue Flashcards

(59 cards)

1
Q

2 principal types of cells in nervous system?

A
  • neurons
  • supporting cells
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2
Q

Supporting cells in CNS?

A

Ependymal cells

Neuroglial cells:

  • Astrocyte
  • Oligodendrocyte
  • Microglia
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3
Q

Supporting cells in PNS?

A
Schwann cells (surround nerve processes)
Satellite cells (surround nerve cell bodies in ganglia)
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4
Q

Neuron cell body

  • is also called?
  • has what type of nucleus?
  • contains…?
A
  • called “perikaryon”

- euchromatic nucleus (very active)

- contains: nissel bodies (stacks of rough ER), ## mitochondria, large perinuclear golgi

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5
Q

Where are Nissl bodies & free ribosomes found in neurons?

A
  • extend into dendrites but not into the axon

- NOT in axon hillock

- dependence on cell body for maintenance

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6
Q

Dendrites:

A
  • Carry information towards the cell body
  • Greater diameter than axons
  • Unmyelinated
  • Arborizations = dendritic trees
  • greatly increase receptor surface of neuron
  • Contain organelles characteristic of cell body
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7
Q

Axons:

A
  • Carry information away from cell body
  • 1 axon for each neuron
  • Origin = AXON HILLOCK
  • NO Nissl and Golgi
  • Terminal arborizations (axon terminals)
  • Contains: Microtubules, neurofilaments, mitochondria &vesicles
  • Plasma membrane =** Axolemma**
  • Contents = Axoplasm
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8
Q

Golgi Type 1 Neuron:

A
  • Motor nuclei of CNS
  • pyramidal cells = long axons (1 meter+)
  • leave gray matter of CNS, traverse white matter, terminate in the periphery
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9
Q

**Golgi Type 2 **Neuron:

A
  • Golgi cells in cerebellum
  • stellate neurons = short axon
  • Axon branched near target organ
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10
Q

sensory neurons

A

receptors TO cns

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11
Q

motor neurons

A

cns/ganglia TO effector cells

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12
Q

interneurons

A

make up 99.9% of neurons

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13
Q

MULTIPOLAR NEURONS

A

1 axon + 2 or more dendrites

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14
Q

BIPOLAR NEURONS

A

1 axon + 1 dendrite

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15
Q

PSEUDOUNIPOLAR NEURONS

A

1 process (axon) that divides close to cell body into 1 processes

(develop as bipolar but processes fuse, then branch)

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16
Q

ANTEROGRADE transport

A

AWAY from cell body TO periphery
- Kinesin

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17
Q

RETROGRADE transport

A

RETURN from axon terminal & dendrites TO cell body
- Dynein

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18
Q

synapses occur between…

A

neuron –> neuron

neuron –> effector cell (muscle, gland)

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19
Q

Types of SYNAPSES

A

axosomatic/axodendritic

(axon bouton –> dendrite)

axoaxonic

(axon bouton –> axon)

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20
Q

ELECTRICAL SYNAPSES

A

gap junctions (ion movement b/t cells)

  • smooth muscle (nexus)
  • cardiac muscle

NOT skeletal muscle

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21
Q

CHEMICAL SYNAPSES

A

presynaptic bouton –> synaptic cleft –> postsynaptic membrane

  • cleft = 20-30nm
  • synaptic vesicles release neurotransmitters
    ex. neuromuscular junction
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22
Q

Schwann Cells

A

- mylenation in PNS

  • originate from neural crest cells
  • create myelin sheath aroudn axon
  • sheath = Schwann cells or neurilemma (Schw.cell cytoplasm)
  • neurilemma = nucleus + most organelles

NO MYELINE = axon hillock + axon terminal

  • Nodes of Ranvier b/t schwann cells in sheath
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23
Q

Where is cytoplams located in the myelin sheath?

A

inner collar of cytoplasm

  • b/t axon + myelin

Schmidt-Lantermann clefts

  • small ilands w/i lamellae of myelin

perinodal cytoplasm

  • @ node of ranvier

outer collar fo perinuclear cytoplasm

  • around myelin
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24
Q

Unmyelinated nerves (PNS)

A
  • enveloped by Schwann cell cytoplasm
  • Single axon or group of axons:

*may be enclosed in a single invagination of Schwann cell surface

* axon rests in a cleft in the cytoplasm of a Schwann cell, with a single mesoaxon

25
Which type of axon conducts impulses faster? what is the action of an impulse "jumping" form node to node called? The speed of transmition is directly related to...
MYELINATED = FASTER - "Saltatory Conduction" - speed directly related to myelin thickness + axon thickness
26
Satellite Cells
- Surround ganglionic neuronal cell bodies - Cuboidal: complete layer around cell body (only nuclei visible) - Originate from neural crest cells - Analogous to Schwann cell \*insulation \*nutrition
27
Neuroglia
- "GLIAL" cells in CNS - More numerous than neurons - Most brain tumors = glial in origin
28
3 types of neuroglia:
**oligodendrocytes** - form myeline in CNS - 1 cell can myelinate multiple neurons **astrocytes** - physical + metabolic support for CNS neurons - found attached to blood vessels **microglia** - phagocytic cells of CNS
29
ASTROCYTES
- Largest of glial cells - 2 kinds: * *PROTOPLASMIC** = prevalent in gray matter * *FIBROUS =** more common in white matter - have elaborate processes - extend b/t vessels and neurons
30
When there is damage to the CNS, which cells form scar tissue?
ASTROCYTES | (fibrous connective tissue)
31
Which neuroglial cells might have a role in regulating tight junctions of Blood-Brain Barrier?
ASTROCYTES
32
BLOOD BRAIN BARRIER
- functional barrier w. tight/occluding junctions sealing capilary endothelium - controls passage of substances fr blood into CNS tissue **=** **protects neuronal microenvironment** - perivascular feet of astrocytes on basal lamina capillaries helps regulate **= stable composition and constant balance of ions in the interstitial fluid** **= Protects neurons + glial cells from potential toxins + infectious agents** NOT in Choroid plexus and posterior pituitary, etc.
33
OLIGODENDROCYTES
- CNS myelin formed by: \*concentric layers of oligocyte plasma membrane - Aligned in rows between axons - gives off several tongue-like processes --\> wraps around an axon **= internodal segment** **- oligodendrocyte forms myelin sheaths for several (3—50) nerve fibers**
34
Microglia
- Part of mononuclear phagocytic system - Present in small numbers ** (proliferate during injury/disease)** - Secrete immunoregulatory cytokines = dispose of unwanted cellular debris
35
Ependyma
- Lines fluid-filled cavities of CNS - Cuboidal to columnar (fluid-transporting characteristics) - several locations = specialized to: **produce cerebrospinal fluid**
36
CHOROID PLEXUS
**- Modified ependyma** (simple cuboidal - produces CSF) **- dialated fenestrated capillaries** **- invaginated fold of pia mater (villi)** - lateral, 3rd, 4th ventricles in brain - removes water from blood + release it as CSF
37
What are the 3 layers/categories of connective tissue sheaths?
endoneurium perineurium epineurium
38
ENDONEURIUM
- thin layer of reticular fibers produced by the Schwann cells - surrounds individual nerve fibers
39
PERINEURIUM
- Surrounds bundles of nerve fibers - sheath of unique connective tissue cells - Cells joined by tight junctions - Form a barrier to passage of most macromolecules - Protects nerve from aggression - numerous actin microfilaments = contractile cells
40
EPINEURIUM
- outermost tissue of peripheral nerve - typical dense connective tissue: (binds fascicles together) - adipose tissue often seen in larger nerve sheaths - carry blood vessels supplying nerves: (vessels branch + penetrate perineurium)
41
SENSORY GANGLIA
- Craniospinal (DRG, cochlear) - Pseudounipolar neurons: \*larger \*close together - Thick fascicles
42
AUTONOMIC GANGLIA
- Sympathetic and Parasympathetic - Multipolar neurons \*smaller \*far apart - Diffuse nerve fibers
43
Autonomic Nwevous System (ANS) conducts impulses to:
- smooth muscle - cardiac muscle - glandular epithelium
44
THORACO-LUMBAR OUTFLOW
**Sympathetic** - norepinepherine - postganglionic fibers
45
CRANIO-SACRAL OUTFLOW
**Parasympathetic** - acetylcholine - preganglionic + postganglionic fibers
46
Enteric Nervous System
- Confined w/i wall of gut - 2 sets of Plexus * *Myenteric (Auerbach)** * *Submucous(Meissner)** - unmyelinated nerve fibers intermingled w neuronal cell bodies - maintain *peristaltic movements* + *secretory function* of the gut
47
Spinal Cord & Spinal Nerves
- Directly continuous with brain - 31 segments: **8 cervical 12 thoracic 5 lumbar 5 sacral 1 coccygeal** - Each segment = pair of spinal nerves - Each spinal nerve is joined to its segment of cord by *roots or rootlets* (grouped as **posterior** (dorsal) or **anterior** (ventral) roots)
48
Grey Matter in spinal cord:
- Anterior Grey Horn - Posterior Grey Horn - Lateral Grey Horn - Grey commissure - surrounds the central canal ## Footnote **has neuron cell bodies, dendrites, axons & glia**
49
White matter in spinal cord:
**pheripheral** - contains mainly myelinated fibers - Arranged in three pairs of funiculus = **Anterior, Lateral &Posterior** - Functionally related bundles of axons called TRACTS
50
CORTEX of brain
**gray matter ** - contains cell bodies, axons, dendrites, and glial cells, synapses
51
NUCLEI of brain
**Islands of gray matter** - found in deep portions of cerebrum and cerebellum
52
WHITE MATTER of brain
contains mainly: - myelinated axons of nerve cells - glial cells - vessels
53
Cerebrum
Cerebral cortex + white matter - Cerebral cortex = 6 layers - PYRAMIDAL CELLS of cerebral cortex: * *found in layers III, V** * *small, medium, large pyramidal cells**
54
PURKINJE CELLS
IN CEREBELLAR CORTEX - located between outer molecular layer + inner granular layer **apical numerous dendrites (arborize in molecular layer)** - have a single axon (not visible in H&E) * *extends into granular layer** * *beginning of outflow from cerebellum**
55
3 layers of CNS connective tissue: MENINGES
COVER BRAIN & SPINAL CORD **Dura Mater:** - outermost **Arachnoid:** - beneath dura **Pia Mater:** - innermost layer; rests directly on brain/spinal cord - delicate layer
56
Some parts of CNS have no Blood Brain Barrier:
- Neurohypophysis - Substantia nigra - Locus ceruleus
57
Response to Injury in Nervous Systems: ## Footnote **"Wallerian degeneration"**
_anterograde_ - degeneration of axon distal to site of injury * *PNS degeneration takes a few days** * *CNS degeneration takes several weeks** \**Some retrograde degeneration also occurs (only extends for several internodal segments)*
58
Response to Injury in Nervous Systems: ## Footnote **"Chromatolysis"**
- loss of Nissl substance from cell body: * *1-2 days after injury** - Changes in cell body are proportionate to: **amount of axoplasm lost from injury** (large amount =CELL DEATH)
59
Response to Injury: **"Motor fiber cut"**
muscles atrophy