Nervous - Week 2 Flashcards
excitable cell
able to use the resting membrane potential to generate an action potential
e.g. muscle, neurons and some endocrine cells are excitable. all others are non-excitable
chemically-gated (ligand) and voltage gated channels
contribute to the movements of ions in and out of the cell along with Na+/K+ ATPase
what is depolarization
the process by which an ion moves in or out of the cell so that the inside of the cell becomes more positive relative to the RMP
voltage- gated Na+ channels open and Na+ rushes in causing inside of cell to be more positive RMP now
(from -70mV –> -30mV)
what is the resting potential of a cell
~ -70mV
resting potential
- K+ channels are not fully closed at rest (making them leaky)
- voltage-gated Na+ channels and chemically gated K+ channels are closed at rest
What is an excitable cell?
An excitable cell is able to use the resting membrane potential to generate an electrochemical impulse called an action potential.
Examples of excitable cells include neurons, muscle cells, and some endocrine cells.
What is the process by which excitable cells generate action potentials?
The action potential is generated through depolarization events within the cell.
Depolarization involves ions moving in and out of the cell, making the inside more positive.
What are the roles of protein channels and ion pumps in excitable cells?
They facilitate the movement of ions in and out of the cell at the plasma membrane.
This includes sodium, potassium, and calcium channels, as well as the sodium-potassium ATPase (Na+/K+-ATPase).
What triggers an action potential in an excitable cell?
An action potential is triggered when depolarization reaches a threshold of -55 mV.
Depolarizations below this threshold are called failed initiations.
What occurs during the depolarization phase of an action potential?
Voltage-gated Na+ channels open, allowing Na+ to enter the cell.
During this phase, voltage-gated K+ channels remain closed.
What happens during the repolarization phase of an action potential?
Voltage-gated K+ channels open, allowing K+ to exit the cell, while voltage-gated Na+ channels close.
This phase helps restore the resting membrane potential.
What is hyperpolarization in the context of an action potential?
Hyperpolarization is when the inside of the cell becomes more negative than the resting membrane potential.
This phase is also known as the relative refractory period.
What is the resting stage of an action potential?
The resting stage is when the resting membrane potential (RMP) has been restored, typically around -70 mV.
This is the state before the next action potential can occur.
Why are Na+ and K+ channels referred to as ‘voltage-gated’?
They are called ‘voltage-gated’ because a change in voltage triggers their opening.
Specifically, Na+ channels open when the voltage exceeds -55 mV.
What occurs when Na+ channels are inactive?
When Na+ channels are inactive, no Na+ can enter the cell, preventing the elicitation of another action potential.
This is during the repolarization phase.
What is the absolute refractory period?
The absolute refractory period is the time during which no action potential can be elicited, as the Na+ channels are closed.
This ensures that action potentials are fixed in height and amplitude.
What is the relative refractory period?
The relative refractory period occurs during hyperpolarization when an action potential can be generated but requires a larger intensity stimulus.
This is because the membrane is more negative than the resting potential.
what is hyperpolarization
chemically gated K+ channels open to bring back into the cell
voltage-gated Na+ channels closed
action potential
an electrochemical impulse generated through
what is relative refractory period
another name for hyperpolarization
- the cell overcorrecting itself, making the cell more negative than at resting potential
anatomy of a neuron
soma
dendrites
axon
axon terminals
myelin sheath
Schwann cells
soma
body of cell
dendrites
- projections of the soma and the site of communications with other neurons