Neuro Flashcards

(36 cards)

1
Q

Cerebellar causes

A

VINDICATE:

Vascular: stroke
neoplastic: NB
degen: FA
Drug/siatrogenic: phenytoin
C..CP
AI: MS
Trauma
Endo: Wilsons, nutritional Vit E

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2
Q

signs of neuro chronicity

A

wasting
deformity
contractures
AFOs well worn
growth asymmetry

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3
Q

paresis vs plegia

A

paresis = weakness
plegia = can’t move

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4
Q

cognitive impairment phrase

A

= “behave younger than I expect”

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5
Q

pes cavus = what DDx

A

spinocerebellar lesion (friedrich’s)
peripheral nerve (CMT)
spinal lesion e.g. spina bifida

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6
Q

Exam signs of myotonic dystrophy

A

myotonic facies - droopy mouth, expressionless (squeeze eyes)
make fist and release
percussion myotonia

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7
Q

types of gait + where is the lesion?

A
  1. hemiplegic (swinging, one arm in) = unilateral spinal/brain
  2. diplegic (both legs swing, adducted) = spinal e.g. transverse myelitis / brain e.g. CP
  3. ataxic (broad based) = cerebellar (with bad turning) / vestibular / sensory
  4. myopathic i.e. high stepping gait = ankle DF weakness from L4, L5, S1 from common peroneal palsy / radiculopathy / polyneuropathy e.g. CMT
  5. myopathic i.e. Trendelenburg (waddling with circumduction) = DMD, BMD, myotonic dystrophy / systemic disease e.g. thyroid, dermatomyositis
  6. choreoform (writhing) = HD, CP, Wilsons
  7. antalgic
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8
Q

Diplegic gait

A

Brain - PVL causing CP!!
Spine - inflammatory e.g. transverse myelitis, congenital e.g. spina bifida, tumour, trauma

Hereditary spastic diplegia

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9
Q

Toe walking gait vs can’t toe walk suggests?

A

Toe walking = DISTAL strength

Can’t toe walk = PF (S1) weakness e.g. CMT
Toe walking = BMD/DMD, CP/spasticity

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10
Q

Can’t heel walk suggests?

A

DF weakness (L5) - CMT!!!, DMD, CP

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11
Q

horner’s sign and causes

A

= ptosis, miosis and anhidrosis

  1. post-cardiac surgery
  2. NB
  3. NF
  4. tumour
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12
Q

ptosis + large pupil vs small pupil
or just ptosis

A

ptosis + large pupil = CNIII palsy
ptosis + small pupil = Horner’s

ptosis e.g. MG, congenital ptosis, dystrophies

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13
Q

causes of unilat vs bilat SNHL

A

unilat e.g. acoustic neuroma, trauma
bilat
1. genetic e.g. connexin
2. syndromic e.g.
3. toxins/drugs e.g. gentamicin
4. infection e.g. rubella / CMV
5. meniere’s

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14
Q

DDx of nystagmus

A
  1. cerebellar
  2. vestibular
  3. congenital
  4. physiological
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15
Q

CNIII, IV, VI palsies

A

III = down and out with ptosis and large pupil
IV = up and in, head tilts away from side of lesion
VI = in

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16
Q

cortical blindness = ?

A

loss of vision but pupillary reflex (CNII) intact

17
Q

cataracts DDx

A

Congenital:
CMV
Turner
T21

Acquired:
Steroid
Alport

18
Q

DDx of ophthalmoplegia

A

UMN - demyelination, tumour, vascular
LMN - nerve e.g. GBS/Bell’s/ICP, NMJ, muscle

19
Q

foot drop causes

A
  1. CMT
  2. common peroneal palsy
  3. L5/S1 nerve palsy
20
Q

CMT vs FA

A

both ataxic, loss of proprioceoption and vibration, pes cavus

FA Romberg’s positive

21
Q

hemiplegia DDx

A

VINDICATE

V: vascular
- vessels e.g. Moya Moya, Sturge Weber, NF
- cardiac
- haem e.g. sickle cell
I: infection - inflammatory e.g. encephalitis
N: neoplasm
C: congenital - will get facial sparing
A: autoimmune
T: trauma
E: endocrine/metabolic

22
Q

what level of LL flexion corresponds with what nerve root? e.g. in spina bifida

A

hip flexion = L1/2
knee flexion = L3/4
ankle DF = L4/5
*saddle area = S3 and below i.e. incontinence

23
Q

key areas to look for in spina bifida

A

HC
neck - VP shunt
back - scoliosis
nystagmus
incontinence (say to look for anal tone)
percuss for bladder
abdo reflex
pressure areas

24
Q

hemiplegia - how to tell where the level of the lesion is?

A

facial weakness side:
cortical = same side as lesion
subcortical = same side
brain stem = opposite side
spine = no facial features

25
key features of SMA on exam
tongue fasciculations prox weakness FACE AND EYE NORMAL no reflexes Ix - SMN1/2 gene
26
key features of MG on exam
fatiguability ptosis facial weakness bulbar involvement +/- prox weakness Ix - tensilon test
27
peripheral polyneuropathy DDx
CMT FA Iatrogenic e.g. vincristine GBS
28
If its UMN, think...? If its LMN, think...?
UMN - brain v brainstem v spinal cord? diplegia - PVL, spina bifida, or rest of vindicate hemiplegia - VINDICATE spina bifida - where's the lesion? LMN 1) ant horn = SMA 2) nerve = CMT/FA/iatrogenic 3) NMJ = MG 4) muscle = myopathy/dystrophy
29
if you think its myopathy/dystrophy - what else to examine/ask for?
1. cardiac 2. scapulae / trendelenburg - pelvic girdle 3. gower 4. wasting and pseudohypertrophy of calves 5. gait - toe walking 6. scoliosis 7. face - dystrophy face is fine, congenital myotonic dystrophy = myopathic faces, myopathy face is bad 1. CK 2. gene panel 3. muscle biopsy
30
basically only causes of distal weakness
peripheral neuropathy SMA congenital myotonic dystrophy
31
cerebellar signs
nystagmus dysarthria past pointing intention tremor dysdiadochokinesia upward drift pronator truncal araxia broad based gait / ataxic gait
32
additional things to ask for in a cerebellar patient
eyes - slit lamp HF abdomen - NB, hepsplen for metabolic bloods - nutritional e.g. Vit E, copper/ceruloplasmin, metabolic, urinary VA/MVA genetics - GA panel
33
signs of FA
1. cerebellar 2. HCM 3. hearing loss 4. pes cavus, romberg's positive 5. LL weakness, no reflexes, no sensation/vibration Ix: triplet repeat study
34
ataxia DDx
1. cerebellar - genetic: AT vs FA 2. vestibular - acute labyrinthitis 3. neuropathy - iatrogenic e.g. vinc - CMT - diabetes 4. loss of proprioception - B12, hypothyroid
35
Ix for floppy weak vs floppy strong
floppy weak and areflexic = neuromuscular CK nerve conduction /muscle studies genetic - SMA1/2, congenital myotonic dystrophy floppy strong = central: congenital vs acquired?? MRI/CT - HIE!!, vascular / tumour endocrine - TFTs metabolic - metabolic screen genetic - PWS infectious
36
facial weakness ddx
unilat - bell's or stroke (forehead spared) bilat - myotonic dystrophy, FSHD, GBS, CP, MG