Neuro Flashcards

(51 cards)

1
Q

Define stroke

A

Sudden onset of focal neurological symptoms caused by interruption of the vascular supply to part of the brain, or intracerebral haemorrhage

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2
Q

Define epilepsy

A

Episodes of increased electrical activity within the brain leading to recurrent seizures

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3
Q

What is ataxia?

A

Loss of coordination of movements

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4
Q

What is rigidity?

A

Hypertonia characterised by increased resistance to passive stretch

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5
Q

Where is lumbar puncture performed and why?

What is the major contraindication and why?

A

Between L3 and L4 - spinal cord ends at L1

RICP - risk of tonsillar herniation

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6
Q

Where does an extradural haemorrhage occur?
Where does the blood come from?
Describe 2 radiological features

A
  • Between the skull and the dura mater (or really between the periosteal and meningeal layers of dura mater)
  • Arterial - usually middle meningeal artery
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7
Q

Why is extradural haemorrhage more likely to occur in younger patients?

A

In older people, the dural layers are more adhesive - less likely to split apart

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8
Q

Between which meningeal layers does a subdural haemorrhage occur?
Where does the blood come from?

A
  • Meningeal layer of dura, and arachnoid mater

- Venous - bridging veins which drain from cerebrum into DVSs

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9
Q

What is it called if blood accumulates in the subarachnoid space?
What is the most likely cause?
What is the typical presenting feature?

A
  • Subarachnoid haemorrhage
  • Rupture of berry aneurysm
  • Thunderclap headache
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10
Q

From which vessel does the anterior cerebral circulation originate?
What about the posterior circulation?

A
  • ICAs

- Vertebral arteries

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11
Q

Outline the course of the ICAs in terms of landmarks and major branches

A
  • Enters cranial cavity via carotid canal
  • Passes through cavernous sinus - pierces dura - enters middle cranial fossa
  • Gives off:
    ophthalmic artery
    posterior communicating artery
    anterior cerebral artery
  • Continues as middle cerebral artery
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12
Q

Which areas are supplied by the anterior cerebral artery?

What would the symptoms be if it was occluded unilaterally?

A

Medial aspects of frontal and parietal lobes, and corpus collosum
Contralateral lower limb motor and sensory deficit

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13
Q

Which areas does the middle cerebral artery supply?

What would be the symptoms of unilateral occlusion?

A
  • Lateral surfaces of cerebral hemispheres
  • Occlusion causes contralateral sensory and motor deficit, particularly upper limb
  • Contralateral hemianopia
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14
Q

Outline the course of the vertebral arteries in terms of landmarks and major branches

A
  • Ascend in transverse foramina
  • Enter via foramen magnum
  • Give off
    Anterior and posterior spinal arteries to SC
    Posterior inferior cerebellar artery (PICA)
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15
Q

Which areas are supplied by the PICA?

What would happen in occlusion?

A
  • Lateral medulla and cerebellum
  • Contralateral loss of pain and temp
  • Ipsilateral nystagmus/ataxia, Horner’s, dysphagia
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16
Q

What happens in occlusion of one of the vertebral arteries?

A

Usually anastomoses mean it’s fine

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17
Q

Which arteries converge to form the basilar artery?

A

Vertebral arteries

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18
Q

What does the basilar artery supply?

What would be the symptoms of occlusion?

A

Cerebellum and pons

Very serious - often coma, bilateral motor and sensory deficit, cerebellar signs, CN signs

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19
Q

How does the basilar artery terminate?

A

Bifurcates into posterior cerebral arteries

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20
Q

Which areas does the PCA supply?

A

Posterior hemispheres - posterior parietal and occiptal

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21
Q

Name 3 major vessels which could be occluded in a posterior circulation stoke

A
  • Vertebral
  • Basilar
  • PCA
22
Q

Which modalities are carried by the dorsal columns?

A

Fine (tactile) touch
Vibration
Proprioception
2-point discrimination

23
Q

Where are the cell bodies of the 1st order neurones of the DCML?

A

Dorsal root ganglion

24
Q

In which dorsal column do fibres from the upper body run?

Lower body?

A
Upper = lateral
Lower = medial
25
In Brown-Sequard syndrome, why are DCML modalities lost ipsilaterally?
Lesion occurs below the level of decussation - decussation occurs in medulla, but lesion is in SC
26
Give some examples of causes of DCML lesion
Vitamin B12 deficiency | Tabes dorsalis
27
Which modalities are carried by the lateral and anterior spinothalamic tracts respectively?
Lateral - pain and temperature | Anterior - crude touch and pressure
28
In Brown-Sequard syndrome, why are the spinothalamic tract modalities lost contralaterally?
Lesion occurs above the level of decussation
29
What is Brown-Sequard syndrome?
Hemisection of the spinal cord resulting in: - Ipsilateral loss of vibration/proprioception/fine touch - Contralateral loss of pain and temperature sensation - Ipsilateral UMN signs
30
What is syringomyelia?
CSF cyst in central canal of spinal cord resulting in selective loss of bilateral lateral spinothalamic tracts - hence loss of pain and temp in both upper limbs.
31
What is an upper motor neurone?
A motor neurone whose cell body is in the cortex, and whose axon remains in the CNS
32
What is a lower motor neurone?
A motor neurone whose cell body is int he ventral horn of the spinal cord (or brainstem) and whose axon projects to the musculature
33
What gives rise to extrapyramidal signs?
Damage to basal ganglia
34
Give some examples of extrapyramidal signs
- Resting tremor - Cog-wheel rigidity - Bradykinesia - Festinating gait
35
What are pyramidal signs?
UMNL signs
36
Give some signs of cerebellar dysfunction
- Dysdiadochokinesia - Ataxia - Nystagmus - Intention tremor - Slurred speech - Hypotonia
37
Give some causes of cerebellar dysfunction
- Posterior fossa tumour - Alcohol - MS - Trauma - Rare - Inherited - e.g. Friedrich's ataxia - Epilepsy medication - Stroke
38
Are cerebellar symptoms contralateral or ipsilateral?
Ipsilateral
39
What are the 4 cardinal signs of Parkinsons?
- Bradykinesia - Rigidity - Postural instability - Resting tremor
40
List 6 UMN signs
- Hyperreflexia - Hypertonia - Positive Babinski - Clonus - Pronator drift - Clasp-knife reflex
41
List 5 LMN signs
- Hyporeflexia - Hypotonia - Wasting - Weakness - Fasciculations
42
What produces the hyperreflexia in an UMN lesion?
Lack of descending inhibition
43
What is clonus?
Repetitive, sustained plantarflexion when the ankle is suddenly, passively dorsiflexed
44
What causes clasp-knife rigidity?
Activation of the Golgi tendon organ causing subsequent sudden relaxation while a spastic muscle is passively stretched
45
What is pyramidal weakness?
Weakness affecting extension of upper limbs and flexion of lower limbs
46
Describe decorticate posturing | Where is the lesion?
Legs extended at knee and ankle Elbows and wrists flexed Lesion above the red nucleus
47
Describe decerebrate posturing | Where is the lesion?
Everything extended Forearm pronated Lesion below red nucleus
48
What is a positive rhombergs?
Unsteady with eyes shut - sign loss of proprioception - problem with dorsal columns Shows sensory ataxia (whereas in negative rhomberg's the ataxia is cerebellar)
49
List some features of a Broca's aphasia
- Staccato speech - Lack of fluency - Understand question, problem is with expression - hence can write down answer
50
List some features of a Wernicke's aphasia
- Fluent and grammatical speech, just doesn't make sense - Inappropriate answers to questions - No problem with expression - problem is comprehension
51
List some signs of a basal skull fracture
- Periorbital ecchymosis - Mastoid ecchymosis - CSF rhinorrhoea/otorrhoea