Neuro II path

Question 1

Glioblastoma’s most important pathology feature

Answer 1

necrosis

Question 2

Answer 2

Low grade astrocytoma

not very good to use chemo because not quickly dividing

can’t tell where it ends/begins, no vascular changes –> low grade

headache/seizures most common symptoms

treat w/ tenazolaminde and radiation

Question 3

Answer 3

Astrocytoma

centrum semiovale; uniform nuclei, low cellularity, characteristic fibrillary background

Question 4

Answer 4

cystic, not necrosis

pilocytic astrocytoma

Question 5

Answer 5

Rosenthal fibers in pilocytic astrocytoma

these show up in glial scarring (astrocytes form glial scars)

Question 6

Answer 6

grade III astrocytoma

see lots of nuclear activity, no vascular proliferation

atypia,

Question 7

Answer 7

glioblastoma

could see cancer cells even in areas where you don’t see tumor

Question 8

Answer 8

glioblastoma, tumor center

can see necrosis, vascular proliferation

hypercellularity

Question 9

Answer 9

oligodendroglioma

“fried egg” appearance

tend to be responsive to chemo; 30s/40s is usual age of dx

test: LOHeterozygosity of chromosome 1P and 19Q (test with FISH)

Question 10

Answer 10

perivascular pseudo-rosettes

epdendymoma

Question 11

Answer 11

Medulloblastoma

A: hypercellularity

B: neuroblastic rosette aka homer-wright rosette

very responsive to radiation and chemotherapy

spread through CSF, drop mets can get into spinal cord

Question 12

Answer 12

meningioma

SLOW growing (no herniation), extra-axial (outside of the brain parenchyma)

can progress to higher grade tumors, not very responsive to therapy

Question 13

Answer 13

meningioma: characteristic whorls with variable degrees of central calcification (psammoma bodies) – most diagnostic histologic pattern of meningiomas

*note* one of the criteria for grade 1 or 2 meningioma is if it’s invaded into the brain tissue

Answer 14

Shwannoma (neurinoma, neurilemmoma)