Neuro-oncology

Question 1

Opsoclonus myoclonus syndrome is associated with what tumor in children?

Answer 1

neuroblastoma

Question 2

How do you typically treat meningeal carcinomatosis?

Answer 2

whole brain radiation + intraventricular methotrexate

Question 3

Gamma knife is usually used to threat what?

Answer 3

focal lesions

Question 4

What do you see on pathology in GBM?

Answer 4

perinecrotic pseudopalisading

Question 5

What tumor has a “friend egg” appereance?

Answer 5

oligodendroglioma

Question 6

What tumor has perivascular pseudorosettes?

Answer 6

ependymomas

Question 7

What tumor has homer wright rosettes?

Answer 7

medulloblastoma

Question 8

What is the predominant antibody in paraneoplastic optic neuropathy?

Answer 8

anti-CRMP-5
*associated with lung cancer

Question 9

What is the predominant antibody in paraneoplastic retinal degeneration?

Answer 9

anti-recoverin or anti-CAR
*small cell lung cancer, thymoma, renal cell carcinoma, melanoma

Question 10

What is the predominant antibody in paraneoplastic subacute sensory neuropathy and neuronopathy?

Answer 10

anti-Hu
*small cell lung cancer

Question 11

What is the predominant antibody in paraneoplastic cerebellar degeneration?

Answer 11

Anti-Yo
*ovarian, GYN cancers as well as breast cancer

Question 12

What mutation is associated with nearly half of anaplastic astrocytomas?

Answer 12

p53

Question 13

“Cancle gutterings” can be seen in what tumor?

Answer 13

subependymal giant cell astrocytoma

Question 14

is SEGA benign or malignant?

Answer 14

benign, WHO grade 1

Question 15

In terms of oligiodendrogliomas, is a 1p19q deletion better or worse in terms of survival?

Answer 15

better

Question 16

Myxopapillary ependymoma almost exclusively where?

Answer 16

filum terminale

Question 17

Neurocytoma is positive for what marker?

Answer 17

synaptophysin
*negative for GFAP (unlikely oligodendroglioma)

Question 18

Psammoma bodies are seen in what brain tumor?

Answer 18

meningiomas

Question 19

Which tumor causes temporal lobe seizures?

Answer 19

DNET

Question 20

Which tumor is filled with “machine oil like fluid” and if spilled can cause xanthogranulomatous inflammation?

Answer 20

craniopharyngioma

Question 21

Where are chordomas usually found?

Answer 21

clivus and sacrococcygeal region

Question 22

Which tumor is an invasive osseodestructive tumor?

Answer 22

chordomas
*made of physaliphorous cells

Question 23

Which tumor has a biphasic pattern with a more compact phase (antoni A) and a looser pattern (antoni B) ?

Answer 23

vestibular schwannoma
*have verocay body

Question 24

What is the size difference between pituitary microadenoma vs macroadenoma?

Answer 24

If it is >1 cm it is a macroadenoma

Question 25

What tumor is positive GRAP and Ki-67

Answer 25

astrocytoma

Question 26

Polymyositis is associated with what malignancies?

Answer 26

non hodgkins lymphoma, lung and bladder cancer

Question 27

dermatomyositis is associated with what cancers?

Answer 27

ovarian, lung, gastric, colorectal, pancreatic and non hodgkins lymphoma

Question 28

What antibody is most commonly detected in paraneoplastic limbic encephalitis?

Answer 28

anti-Hu strongly associated with small cell lung cancer

Question 29

opsoclonus myoclonus syndrome is most commonly associated with what anitbody especially in the setting of breast cancer?

Answer 29

anti-Ri (ANNA 2)