Neuro7 - 31 Flashcards
(31 cards)
Why is tube to laminae an important transition?
Major conditions can arise, correlates highly with migration abnormalities
What is lissencephaly?
Smooth brain (agyria)
How thick is the neural tube initially?
One cell
How do neural cell types divide?
Nuclear translocation
When does division massively increase?
Massively after neuropores close
What is secreted by the Cajal-Retzius cells?
Reelin
What is reelin?
3460 a/a ECM-like protein
What is reelin named after?
Reeler mouse mutant - motor deficit leads them to reel around, as if drunk
What make the reeler mouse reel?
Lack of cortical layers - similarities to lissencephaly
What is Cajal-Retzius cell development regulated by?
Foxg1
What does Foxg1 -/- have?
Extra CR cells
Define macrodevelopment
Inside-out development
What is neural cell movement most often associated with?
Radial glia
When do most radial glia appear?
After development
Which radial glia don’t appear after development?
Bergmann glia - in the cerebellum
Where do radial glia run from and to?
Ventricular to outer layers - like spokes
How are cortical glia described?
Tangential - run perpendicular to radial glia
Outline cerebellar system of cells
External surface, molecular (relative cell free), big cells (Purkinje), dense granular layer
Where does the cerebellum develop?
Boundary of mid and hindbrains, on roof of 4th ventricle
What seperates the cerebellum from the 4th ventricle?
Medullary vellum
What forms the geminal trigone?
Rhombic cells at superior and inferior edges of medullary velum
What form the external germinal layer of the cerebellum?
Superior rhombic lip cells
What form the pontine nuclei and inferior olive?
Inferior lip cells
What does the external germinal layer of the cerebellum form?
Granule cells - neurons
