Neuroeffector Drugs Intro Flashcards Preview

Pharmacology 2017 > Neuroeffector Drugs Intro > Flashcards

Flashcards in Neuroeffector Drugs Intro Deck (14):
1

Sympathetic Nerves
Fight or Flight

Originate in the Thoracic and Lumbar sections
Synapse in the paraverteberal symp. ganglia (22 pairs)
Have short Pre-Ganglionic neurons (Ach)
Long Post-Ganglionic neurons (NE)

2

Parasympathetic Nerves
Rest and Digest

Originate in the Cranio-Saccral regions
Long pre-ganglionic neurons (Ach)
Short post-ganglionic neurons (Ach)

Cranial Nerves III, V, VII, IX, and X contain parasympathetic fibers.

3

Adrenal Medulla

Kidney Hat
Innervated by pre-ganglionic Cholinergic neurons
Chromaffin cells release Epi into the blood stream

4

Nicotinic

Pre-Ganglionic

5

Muscarinic

Parasympathetic post-ganglionic

6

Adrenergic

Sympathetic post-ganglionic

7

Alpha Receptors

activate vasoconstriction

8

Beta Receptors

activate vasodilation

9

Dobutamine

Selective B1 receptor agonist
Used to treat shock and cardiac arrest
Cannot be given orally
Longer half life than epi but still only 2 minutes

10

Albuterol

selective B2 adrenergic receptor agonist
used to treat athsma
a poor substrate for MAO, it has a half life of several hours
increases heart rate, elevates blood glucose, muscle tremor
Contraindicated by cardiac disease & diabetes

11

Phenylephrine

selective A1 adrenergic receptor agonist
used as a vasoconstricting decongestant
half life of several hours
contraindicated by MAO-Is

12

Clonidine

Adrenergic A2 receptor agonist
Used to treat HTN, administered by patch or orally
Half life of several hours
Used in eye drops (redness and glaucoma)

13

Phenelzine (Nardil), Tranylcypromine (Parnate), and Selegiline (Deprenyl)

All inhibit MAO activity, which increases the action of catecholamines (epi and norepi) by slowing their degradation (this makes it a sympathomimetic drug)

Potential hypertensive crisis when taken with other sympathomimetics or foods rich in dietary amines (wine, cheese, beer, chocolate, etc) which are also broken down by MAOs

14

Methylphenidate (Ritalin), and Dextroamphetamine (Adderall)

bind to re-uptake transporters (NET), and vesicular transporters (VMAT) to cause reverse catecholamine transport. Indirect acting sympathomimetics.

taken orally, crosses blood/brain barrier, can cause HTN, tachycardia, insomnia, and GI problems.