neuroleptics - 1st gen antipsychotics Flashcards Preview

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Flashcards in neuroleptics - 1st gen antipsychotics Deck (18)
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0
Q

what are the 5 phenothiazines?

A
  1. chlorpromazine
  2. fluphenazine
  3. trifluoperazine
  4. perphenazine
  5. thioridazine
1
Q

name the 8 first generation antipsychotics

A
  1. chlorpromazine
  2. fluphenazine
  3. trifluoperazine
  4. perphenazine
  5. thioridazine
  6. thiothixene
  7. loxapine
  8. haloperidol
2
Q

what drug is a thioxanthine?

A

thiothixene

3
Q

what drug is dibenzoxazepine?

A

loxapine

4
Q

what drug is butyrophenone?

A

haloperidol

5
Q

what dz and sx are the first generation antipsychotics used to tx?

A

schizophrenia (hallucinations, delusions), and movemt dis in Huntington’s

6
Q

what’s the major ADR of the first generation antipsychotics? (what are the first gen’s again?)
(TTT - 3operas; when u get a flu, you need a halo (angel), lox (omegas), and perfectionist (at taking care of u), and chlorine to kill all the germs)

A

NMS;

chlorpromazine, fluphenazine, trifluoperazine, perphenazine, thioridazine, thiothixene, loxapine, haloperiodol

7
Q

T/F: the first gen antipsychotics have effect on negative sx of schizophrenia

A

F; little effect on negative sx.

8
Q

what are some of the ADRs of 1st gen antipsychotics?

A

EPS, TD, sedation, postural hypoTN, weight gain, anticholinergic effects, sexual dysfnc, hyperprolactinemia

9
Q

what is catalepsy?

A

trance, mm rigidity, lack of voluntary movement.

10
Q

DA depleting, VMAT2 inhibitor

A

Tetrabenazine

11
Q

mm relaxant

A

dantrolene

12
Q

for movmt disorders in Huntington’s and for tardive dyskinesia

A

tetrabenazine

13
Q

to tx malignant hyperthermia (assoc with NMS)

A

dantrolene

14
Q

ADR of tetrabenazine

A

NMS

15
Q

which ones tx huntington’s movmt dis at low doses?

A

chlorpromazine, fluphenazine, haloperidol

16
Q

which drug produces more EPS than chlorpromazine?

A

fluphenazine, haloperidol

17
Q

which drugs produce less EPS than chlorpromazine?

A

perphenazine, loxapine