Neurological chronic diseases Flashcards
(45 cards)
What are the most common neurological chronic diseases?
Parkinsons
Multiple sclerosis
Motor neurone disease
What is the main neurotransmitter affected in people with parkinsons and where is it transmitted from in the brain?
Dopamine
the basal ganglia - the area responsible for movement
What are some risk factors for parkinsons?
certain pesticides, head trauma, gender (more in males than females), anaemia in women and genetics
What is the cause of parkinsons?
the cause is unkown
What is the median age of diagnosis of people with parkinsons?
59
What is the median age of death of people with parkinsons?
83.3
What are the motor signs and symptoms of parkinsons?
- The classical triad of (resting) tremor, rigidity (muscular stiffness) and akinesia (slowness and difficulty in initiating movement)
- Flexion on the trunk, gait difficulties with shuffling and freezing and reduced arm swing
- Akinesia results in difficulty turning in bed, small handwriting and a soft voice, which is difficult to understand
What are the non-motor signs and symptoms of parkinsons?
- Autonomic symptoms – postural hypotension, abnormal sweating
- Urinary and bowel dysfunction, sexual difficulties
- Cognitive decline, depression and anxiety
- Sleep disturbance, fatigue
- Loss of smell (anosmia)
- Sensory phenomena, including pain not responsive to analgesia if caused by a lack of levodopa
What medication can treat a lack of dopamine?
Levodopa combined with dopa decarboxylase inhibitor to prevent the peripheral side effects of levodopa, remains the first line treatment for the disease
synthetic dopamine agonists (pramipexole; pergolide; bromocriptine; cabergoline; and apomoprhine) which act on the dopamine receptor sites with a similar but weaker action
What is the off or on state for people with parkinsons?
o The off state describes the patient when the signs and symptoms are most obvious
o The on state describes the best the person can achieve with medications
What type of nursing care might the patient with parkinsons need?
Full nursing care for feeding, showering and transfering
when in on state patient may be independent or only need assistance while medications are in affect
What might the physio and occupational therapist assist the patient with?
• Difficulty with gait, posture and balance means that mobility is often compromised, and showering, toileting and ambulating require careful assessment by a physiotherapist and an occupational therapist
What type of aids might the person with parkinsons need?
walking aids
Why is it important to differentiate tremor from dyskinesia?
to ensure that correct treatment options are considered
What is Amomorphine?
• a by-product of morphine without opiate activity, is an injectable dopamine agonist that has a comparable effect to levodopa
o Can be used as an injection to rescue the person from the ‘off’ states or as an infusion for management of symptoms
What are some side effects of dopamine agonists?
hallucinations Postural hypotension hyper-sexuality excessive eating excessive gambling
Why should medications not be stopped abruptly in people with parkinsons?
can lead to a rare, but life threatening condition called neuroleptic malignant syndrome
This syndrome is associated with worsening of Parkinson’s signs, altered mental state, hyperpyrexia, tachycardia, raised serum CK, renal insufficiency and a high mortality
how is body image affected for people with parkinsons?
- A stooped posture, slowness in movement and gait disturbances ages the person
- Drooling, reduced facial expression, unblinking eyes, slowness in thought (bradyphrenia) and voice disturbances not only lead to a loss of personal dignity, but also interfere with communication and the person may appear of low intellect
- Social isolation for both the person with Parkinson’s and the carer can ensue
- People with the disease may resent their wishes, feelings and opinions being interpreted and reported by others and many often feel shunned by previous friends as the condition progresses
How is quality of life affected of those who have parkinsons?
• role change, independence, working, driving and physical comfort pain sexual limitations psychiatric complications depression
How can you keep up communication with someone who has parkinsons?
o Ensuring face to face position, making eye contact and using cues to encourage people to speak key words loudly
- allow them time to express themselves and check that you have understood their intended message
- listen to content rather than delivery of speech to gauge needs, mood and cognitive function
What is Multiple sclerosis?
Multiple Sclerosis is a demyelinating disease affecting the nerve fibres in the white matter of the brain, the spinal cord and the optic nerve.
A process of acute inflammation causes demyelination to occur. In some instances the body remyelinates the axon and function returns
In other situations the myelin is lost and scarring or sclerosis occurs, slowing or impairing the transmission of the nerve impulse and increasing axon vulnerability to environmental influences
How is MS diagnosed?
Brain MRI with visually evoked potential (measurement of sensory, visual and auditory nerve conduction)
Spinal cord MRI
Positive CSF
What are the 4 categories of MS?
Relapsing remitting MS
Primary progressive MS
Secondary progressive MS
Progressing relapsing MS
Explain Relapsing remitting MS
this is the most common form (attributed to 85% of MS cases) characterised by episodic attacks of neurological symptoms, commonly sensory disturbance that may not be accompanied by clinical signs. Between attacks the person recovers partial or complete neurological function
Symptoms:
- in one or more limbs
- optical
- cerebellar
- vestibular
- pain
- depression
- Sleep disturbances
- Fatigue