Neurological degenerative disorders

Question 1

Alzheimers

Answer 1

def. Ach. w/ neurolitic plaques & neurofibrillary tangles. ApOE. PS1 & Ps2 & APP.

Question 2

what does donepezil/ aricept do (alzheimerS)

Answer 2

inhibit ACHE

Question 3

what does memantine do (alzheimers)

Answer 3

glutamate receptor blockers

Question 4

multiple sclerosis

Answer 4

autoimmune destruction of CNS myelin. genetic predisposition & then trigger. Both sensory & ,motor.

Question 5

methotrexate (ms)

Answer 5

immunoregulative - must give with folate & is hepatotoxic

Question 6

Amyotrophic lateral sclerosis

Answer 6

Genetic w/ SODI or sporadic. FR’s dmg motor neurons.

Question 7

what is riluzole (ALS)

Answer 7

antiglutimate drug

Question 8

parkinsons

Answer 8

destruction of dopamine neurons in striatum nigra in basal ganglia -> impaired extrapyramidal -> impaired coordination

Question 9

Myasthenia gravis

Answer 9

autoimmune l/o ach receptor on endplate

Question 10

huntingtons

Answer 10

decreased GABA, decreased ACH, increased dopamine.

Question 11

GB

Answer 11

AUTIMMUNE IN THE PSN