Neurology Flashcards
(53 cards)
Name 5 peripheral causes of vertigo
BPPV
Menierres disease
Acute Vestibular Neuritis
Viral or suppurative Labyrinthitis
Acoustic Neuroma
Aminoglyocside ototoxicity
Name 5 central causes of vertigo
Cerebellar CVA
Cerebellar tumour
Vertebro-basillar insufficiency
Brain stem (any posterior circulation) CVA
Multiple Sclerosis
Drug toxicity- anti epileptics, anti depressants, antimalarials
Name 5 cerebellar signs on physical examination
broad based ataxia
nystagmus
intention tremor
abnormal finger nose test (past pointing)
abnormal heel- shin test (dysmetria)
abnormal heel-toe test (fall to side of lesion)
Complete table re clinical features of vertigo
Classic symptoms of Meniere disease
Tinnitus, vertigo, sensorineural hearing loss
Usually episodic in middle aged men
Associated with vomiting, nausea and sweating
Treatment of Meniere Disease
salt restriction
HCT 25mg daily
avoid caffeine
Classic BPPV presenting symptoms
acute onset, often after waking
worse with movement of head
improves when head still
nystagmus on provocative testing- Hall pike
F>M
50-60
BPPV treatment
Prochlorperazine 12.5mg IV
Promethazine 10mg TDS
Epleys Maneuvere
Classic Acute Vestibular Neuritis presenting symptoms
Classically follows viral illness
Onset over few hours
Persistent vertigo when head is still and eyes closed
Associated with vomiting
Nystagmus at rest
Treatment of Acute Vestibular Neuritis
Prednisolone 125mg daily, decrease by 25mg every 3 days
Prochlorperazine 25mg IV
Peripheral vertigo clinical signs
able to sit or stand without assistance
no cranial nerve or cerebellar signs
unidirectional fatiguable nystagmus
unilateral abnormal head impulse test
no skew
Central vertigo clinical signs
unable to sit or mobilise without assistance
cerebellar signs
other cranial nerve signs
negative head impulse test (eyes fixed on nose)
nystagmus- vertical, torsional, non fatiguable and no latency with head movement
skew present -usually vertical
Best Imaging for vertigo
MRI
CT often not helpful- will miss small cerebellar strokes
Stroke Mimics- name 10
hypoglycaemia/ hyponatraemia
Hemiplegic Migraine
Post ictal Todds paresis
Brain tumour
Brain abscess
Meningoencephalitis
Head injury- subdural haematoma
Multiple Sclerosis
Wernickes- Korsakoffs syndrome
Drug toxicity
Bells Palsy
Name 3 non cardiac thromboembolic causes of ischaemic stroke
Carotid artery atheroma
vertebral artery atheroma
Small vessel disease- lacunar infarct
Name 5 cardiac thromboembolic causes of ischaemic stroke
AF
Atrial myxoma
Valve disease
Mural thrombosis
PFO
Name 6 non cardioembolic causes of ischaemic stroke
Cerebral vasospasm post SAH
Aortic or vertebral artery dissection
Cerebral vasospasm- pre eclampsia
Moyamoya syndome
AFE
Gas embolism
Arteritis
Cardiac arrest- low flow state
Name 5 causes of Haemorrhagic stroke
HTN ++++++
liphylanosis
AVM
Aneurysm
Bleeding diathesis- oral anticoagulation or inherited
Secondary haemorrhage into infarction or tumour
Amyloid
Indications for thrombolysis in stroke
Onset of symptoms within 4.5 hours
Significant persistent neurological deficit
CT scan which does not show SAH or bleeding risk
Does not have any absolute contraindications
No other terminal disease or severe comorbidities
What are the Absolute contraindications for thrombolysis in CVA
-Onset of symptoms > 4.5 hours
-INR >1.7
-oral anticoagulation taken in the last 12 hours
-BP > 185 systolic or 110 diastolic
-Platelets < 100
What are the relative contraindications for thrombolysis in CVA
-Pregnancy
-Known MI in the past 30 days
-known IC bleeding past 30 days
-surgery/biopsy or trauma of internal organs past 30 days
-severe comorbidities
-advanced dementia
-CPR or arterial puncture past 30 days
Name 2 thrombolysis drugs and doses
-altelpase- 0.9mg/kg max 90 mg. Give first 10% as a push and the other 90% over 60 minutes
-tenecteplase- 0.25mg/kg. Max 25 mg given as a single push
-need to be given through dedicated IV line
What are the main complications of thrombolysis treatment
-ICH
-internal bleeding-retroperitoneal, GI/GU, solid organ
-external bleeding- massive epistaxis
-angioedema (give icatabant 30 msg s/cut- don’t want to cause HTN)
-anaphylaxis