Neurology Flashcards

(53 cards)

1
Q

Tests to do if query myasthenia gravis

A

Short acting anticholinesterase agent in MG would transiently improve symptoms.
Do chest imaging to rule out thymoma
Do CT brain
Blood as,pale for anti acetylcholinesterase antibodies

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2
Q

Problems with MG

A

Progressive fatiguable weakness
They also have problems with mastication, talking, drinking, swallowing. Aspiration pneumonia and resp failure can result as unable to clear secretions

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3
Q

Neuro systems review

A
Headaches
 Altered vision
Fits, faints, funny turns
Hearing difficulties 
Memory problems
Speech and swallowing difficulties 
Weakness
Numbness or tingling
Incontince or retention
Erectile dysfunction
Balance or coordination difficulties 
How is it affecting ADLs
FH
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4
Q

Progressive weakness without sensory loss. Arm twitching. Legs giving way. Change in speech. Father died when in 30s.

A

Amyotrophic lateral sclerosis- UMN AND LMN lesions. Some genetic component but sporadic mutations more common

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5
Q

Severe painful unilateral headaches. No warning. Eye watering, nasal stuffiness. No symptoms between headaches. Usually at night.

A

Cluster headache

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6
Q

Tight band like headache precipitated by stress

A

Tension headache

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7
Q

Brief stabbing pain when chewing or brushing teeth

A

Trigeminal neuralgia

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8
Q

Photophobia, neck stiffness, fever, headache

A

Meningitis

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9
Q

Sudden onset excruciating headache. Reaches climax within minutes

A

Subarachnoid haemorrhage

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10
Q

Unilateral landing headshcem multiple triggers, lasts for hours, aversion to bright lights, can be preceded by aura

A

Migraine

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11
Q

20 minute unilateral debilitating headache p. Retro orbital pain with red eye and watering

A

Cluster headache

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12
Q

Headache triggered by changes in position or exertion. Changes in vision or headache with leaning forward, coughing, sneezing

A

Raised Icp- SOL- tumour, abscess. Hydrocephalus

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13
Q

Pain around eyes with blurred vision and halos around lights

A

Acute angle closure glaucoma

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14
Q

Scalp tenderness, unilateral. Jaw claudication .

A

Temporal arteritis

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15
Q

Red flags for headaches

A
Sudden onset 
High severity
Fever
New onset neurological deficit 
New onset cognitive dysfunction 
Change in personality
Impaired GCS
recent head trauma
Headache triggered by cough, sneeze, exercise or change in posture
Headache with halls around lights 
Headache with jaw claudication
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16
Q

LOC triggered you vigorous exercise in a young person

A

Hypertrophic cardiomyopathy or cardiogenic syncope

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17
Q

Triggered by pain, fear, prolonged standing. Preceded by pallor, nausea, sweating, no confusion afterwards

A

Vaso vagal

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18
Q

Triggered when standing up

A

Postural hypotension

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19
Q

Collapse on shaving or turning head

A

Carotid sinus sensitivity

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20
Q

Crying out, falling to floor, period of stiffness followed by rhythmic jerking that gradually decreases in amplitude and frequency, period of confusion after

A

Generalised tonic clinic seizure

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21
Q

LOC, pale and sweaty beforehand, jerking of limbs, eye rolled back short duration, no confusion

A

Vaso vagal

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22
Q

Violent shaking, head moving side to side , arching back, episodes of stillness before starting again, forced eye closure

A

Psychogenic non epileptic struck

23
Q

Facial weakness on right side, motor weakness on left

A

Right side brainstem lesion

24
Q

Left weakness and sensory changes

A

Right hemisphere lesion

25
Lower motor neurone weakness in all four limbs and loss of sensation
Peripheral neuropathy
26
UMN signs in all four limbs and loss of sensation
Spinal cord lesion
27
Loss of vision and pain in eye. Incontinence. Leg weakness
Think MS | Do MRI brain and spine
28
Elderly patient, head trauma, worsening lethargy, confusion
Subdural haematoma | Do CT
29
Progressive weakness, cannot walk unaided, started off at numbness and tingling in hands and feet. Now SOB. Had food poisoning three weeks ago Absent reflexes , glove and sticking sensory loss
GBS Differential of transverse myelitis Do LP and MRI
30
Treatment of GBS
Iv immunoglobulin Or plasma exchange DVT prophylaxis, lots of obs
31
LP with high protein but normal white cells
GBS
32
Key features of GBS
``` Peak disability in four weeks Antecedent trigger Areflexia CSF- high protein, normal cell count Generally spontaneous recovery occurs ```
33
Differentials of GBS
``` Acute myelopathies Botulism Diphtheria Lyme disease Vasculitis neuropathy ```
34
Oligoclonal bands in CSF and not in blood
Think MS
35
Four limb symptoms and urinary disturbance
Cervical spine
36
Right sided facial weakness. Whole face, no sparing. Sensation normal
Right LMN lesion. Bell’s palsy
37
Treatment of Bell’s palsy
Steroids aciclovir Tape eye closed at night Can initially worsen before getting better
38
Painful vesicles affecting external ear, palate. Facial weakness. Ear and face pain
Ramsay hunt syndrome Treat with aciclovir within 3 days of onset and steroids
39
Young female with foot slapping when walking after a weekend kneeling
Common peroneal nerve palsy. Get nerve conduction studies Ask about back pain as the palsy could be due to prolapsed disc.
40
Wrist drop
Radial nerve palsy. Often due to compression on mid shaft of humerus. Get neurophysiology assessment. Give splint to help with function
41
Young man, blurring in right eye, discomfort and pain in movement of eye. Reduction in vision in right eye. Left eye normal
Optic nerve problem. Eg optic neuritis
42
Blood tests following RAPD
Serum b12 as deficiency can mimic optic neuropathy Look for evidence of multi system inflammation No pun specific inflammatory markers eg CRP, ESR Specific immunological markers- ANA, ANCA, serum ACE, Infectious triggers eg HIV, syphillis, hep B and C Rarer antibodies eg Devics MRI scan would show high signal in optic nerve
43
Causes of an unsteady gait
Cerebellum problems leading to cerebellar ataxia Dorsal column problem leading to sensory ataxia Peripheral nerve problems leading to sensory ataxia Vestibular problems
44
Features of cerebellar disease
Vertigo and nausea Voice changes- staccato Poor coordination in arms and legs One side of body affected- ipsilateral lesion
45
Vestibular problems
Nausea Vertigo Room spinning Can lead to hearing loss and tinnitus
46
Unsteady gait and sensory loss. Pins and needles. Balance worse in dark. Fall over when eyes closed
Sensory ataxia
47
Unsteady gait and bladder disturbance
Spinal cord lesion
48
How to treat MS relapse
High dose steroids, give PPI alongside this | Try to treat symptoms of the relapse
49
Medications used in MS
Steroids to treat relapse Disease modifying agents eg beta interferons Baclofen- reduce muscle spasticity. Can be very sedative through Gabapentin- reduce neuropathic pain Sertraline- depression often common with chronic disease Oxybutinin- if urge incontinence a problem but can lead to bladder retention
50
How to treat neuropathic pain
Pregablin Gabapentin Tricyclic antidepressant eg amitriptylline Carbamazepine (useful in trigeminal neuralgia)
51
Side effects of beta interferons
Injection site reaction or rash Flu like symptoms for a few days Reduced immune system
52
Conditions that can mimic MS
Devics syndrome- neuromyelitis optics, affects spinal cord and optic nerve. Test for NMO antibodies Anticsediolipin antibody syndrome Neurosarcoidosis Sjogrens
53
Side effects of steroids
``` Acne Blurred vision Cataracts Glaucoma Easy bruising Difficulty sleeping High blood pressure Increased appetite and weight gain Increased Body hair Ulcers Diabetes Osteoporosis Impaired wound healing ```