Neurology Flashcards
(114 cards)
1
Q
cauda equina syndrome vs conus medullaris syndrome
A
CES: spinal roots, more radicular pain, late onset fecal and urinary incontinence, arreflexia
CMS: early onset fecal/urinary incontinency, hyperreflexia- mix of LMN and UMN
2
Q
heat stroke symptoms
A
temp over 104
CNS dysfunction
rhabdo, renal failure, resp failure, DIC
3
Q
non traumatic SAH is most commonly due to
A
ruptured berry aneurysm
4
Q
most common cause of IC hemorrhage in children
A
cerebral AV malformation
5
Q
another word for vasovagal syncope
A
neurocardiogenic syncope
6
Q
what is hypertensive vasculopathy
A
charcot bouchard aneurysm due to high BPs can cause deep intracerebral hemorrhage like putaminal or lenticular hemorrhage
7
Q
bilateral trigeminal neuralgia caused by
A
MS
8
Q
what the thresholf for hyperglycemic hyperketotic state
A
blood sugar >600
more commonly >1000
9
Q
sphenoid bone fracture will cause what kind of brain bleed
A
acute EPIdural hematoma
10
Q
Spinal Epidural Abscess
A
- signs: back pain, fever, neurological symptoms (you may see distended bladder)
spreads hematologically from staph infection.
need MRI of spine to diagnose
11
Q
spinal cord compression symptoms
A
focal back pain
early: hyporeflexia of LE, symmetric LE weakness
late: hyper-reflexia, Babinski, paralysis
12
Q
Uhthoff syndrome?
A
worsening MS in warm temp
13
Q
acute headache, nausea, blurry vision, sluggish and dilated pupil
A
angle closure glaucoma
14
Q
what meds cause acute angle closure glaucoma
A
decongestants, antiemetics, anticholinergics
15
Q
essential tremor
A
tremor with intention motion
16
Q
migraine medical treatment
A
acute: sumitriptan and NSAIDs
prophylactic: Amitryptiline, B blocker, topimirate
17
Q
dopamine pathways
A
- nigrostriatal- movement disorders
- mesolimbic- psychotic disorders like hallucinations or euphoria
- tuberoinfundibular- prolactin
18
Q
HSV encephalitis CSF findings
A
- lymphocytic pleocytosis
- RBC due to temporal lobe hemorrhage
- normal opening pressure, normal glucose
19
Q
CSF OP > 250 but otherwise normal CSF
A
pseudotumor cerebri aka idiopathic intracranial htt
20
Q
IIH/pseudotumor cerebri medication causes
A
Growth Hormone, tetracyclines, hypervitamin A (isoretinoin)
21
Q
ischemic CN III palsy vs compression CN III palsy
A
inner somatic n
superficial parasympathetic
ischemic will affect inner n’s first and spare the pupils
whereas compression will affect both EOM and pupils
22
Q
what is paradoxical agitation?
A
benzodiazepines can cause agression and agitation in the elderly (1%)
23
Q
whats the mechanism by which low CO2 can cause decreased ICP
A
low CO2 causes cerebral vasoconstriction which decreases CBF
24
Q
what are headache warning signs that would req early imaging
A
- new characteristics, is this diff from previous headaches
- onset >40 yo
- onset trauma
- present at awakening
- neurologic findings/defecits
25
what is the Wernicke Encephalopathy triad
gait ataxia, ocular dysfunction, and encephalopathy
26
what are amitrityline side effects?
anticholinergic - dry mouth
histamine- sleepiness
alpha agonist- ortho static hypotension
27
EBV DNA in CSF is specific for ?
primary CNS lymphoma
28
how do you treat severe cancer pain
short acting opioid
29
what are the treatment options for schitzophrenia suspected?
if pt is agreeable, do oral not IV or IM longacting!
there is no different btw the antipsychotics except for clozapine, which has severe agranulocytosis and should be saved for pts unreponsive to 1st line tx
30
fasciculations are 1. upper? 2. lower? motor neuron findings?
fasciculations indicate LMN damage
31
where is Broca's area
Dominant Frontal Lobe
32
what is wallenberg syndrome
it is a lateral medullary infarct
can cause ipsilateral face and contralateral body loss of pain and temp
ipsilateral Horner's and bulbar symptoms
vestibulocerebellar impairment.
33
what is subclavian steal?
when the subclavian A is stenosed and steals reverse blood flow from vertebral A.
symptoms include asymettrical BPs in UE, dizziness with exercise of UEs, and parasthesia in UE
34
how to manage acute MS flare
GC, 2nd line plasmapheresis
35
where is the lesion causing hemineglect
R (non dom) parietal lobe
36
for what kind of stroke would you order a contrast vs noncontrast CT?
hemorrhagic- non contrast
| ischemic- contrast
37
cavernous sinus thrombosis
infection from face affects cavernous sinus and causes ICH. CN III , IV, and VI are affected.
38
most common cause of spontaneous (non traumatic) lobar hemorrhage in >60 yo
amyloid angiopathy
39
most likely AE of status epilepticus
cortical necrosis
40
drop arm test- what is it? whats it sensitive for?
passively raise pt's arm over head, and have them bring it back down. if they suddenly drop the arm and are unable to lower it in a controlled fashion it is indicative of a supraspinatous injury.
41
GBS treatment
supportive care
IVIG
plasmapheresis
42
what would hypokalemia present as in clinic?
| what about on EKG?
in clinic: muscle weakness, cramping, and decreased DTR
| U waves, flattening of T wave, PVCs,
43
syringomyelia clinical findings?
muscle wasting, motor weakness, loss of pain and temperature in arms and hands/ or capelike distribution
-dorsal columns spared
44
who would benefit from carotid endartectomy?
- symptomatic- has had TIA
- WITH carotid occlusion of 70-99%
without both of these pts can do anti-platelets and statin therapy
45
steppage gait is caused by?
L5 radiculopathy or common peroneal neuropathy
46
following a subarachnoid hemorrhage whats a risk in the first day? whats a risk after 3 days?
- rebleed within 24 hr
| - cerebral vasospasm
47
alcoholic cerebellar degeneration
>10 yrs alcoholism causes toxic injury to purkinje cells in cerebellar vermis, leading to problems with gait/falls in the setting of a normal sensory exam.
48
Pick's disease
behavioral variant of Frontaltemporal dementia. 1. behavior changes 2. hoarding/compulsivity 3. executive function/memory
49
how to treat delirium?
Haloperidol
50
SCC vs cauda equina vs conus medullaris
a sensory level excludres CES
conus has back pain, urinary incontinence but is less likely to have sensory involvement or weakness
SCC has a clear sensory level with sensory loss and incontinence and weakness
51
asymmetric ascending paralysis over the course of hours
tick toxin release
52
MRI of Alzheimer's
temporal and parietal atrophy
| expecially hippocampi
53
what is the theory for NPH pathophysiology?
decrease of CSF absorption or some form of obstruction causes a a transient increase in pressure, but the ventricles increase in size and pressure normalizes
54
central cord syndrome vs anterior cord syndrome
central- usually following whiplash, causes decreased sensory and motor in arms and spares the legs
anterior- trauma injury to ASA, loss of motor and sensory of pain/temp
55
CT showing minute punctate hemorrhages and blurring of grey and white interface
diffuse axonal injury
56
Riluzole
glutamate inhibitor approved for ALS. can prolong life span and time to trach
57
intracranial hypertension
headache worse at night, nausea/vom, focal changes ex- vision
58
lumbar spinal stenosis prov/palliation
prov- extension ex: standing or walking downhill
| pall- flexsion, ex- sitting or walking uphill
59
acute dementia and sharp triphasic on EEG is?
CJD
60
thalamic pain syndrome
paroxysmal burning pain esp sensitive to light touch
61
cluster headache treatment? prophylaxis?
tx- 100% O2, IM Sumitriptan
| ppx- Lithium, Ca ch blocker
62
botulinum treatment
equine antitoxin therapy
63
TPA window
3-4.5 hr
64
Livedo Reticularis
a mottled skin appearance
| an AE of amantidine
65
anterior shoulder dislocation
causes injury to axillary n
| happens when force applied to ex rot, abducted shoulder.
66
Parkinsonian gait
narrow based, shuffling, fenistrating, hypokinetic, no movement of arms
67
Brown Sequard symptoms
ipsilateral hemiparesis, loss of proprioception and light touch at LEVEL of injury and below
contralat loss of pain and temp 1-2 BELOW LEVEL of injury
68
what does MRI of brain mets look like?
multiple circumscribed lesion at gray and white matter junction with surround edema
69
treating a Myasthenia Crisis
HOLD the pyridostigmine
| give plasmapheresis, or IVIG, with corticosteroid
70
central cord syndrome
UE weakness that spares the lower extremities
| caused by hyperextension in a pt with osteoarthritis
71
whats the treatment for idiopathic intracranial hypertension?
acetalzolamide +/- furosemide
72
how to work up amaurosis fugaux?
carotid doppler
73
2 most common causes of brain abscess
- strep viridans
| - staph aureus
74
IIH most serious consequence?
blindness
75
extra axial well circumscribed meningeal mass?
meningioma
76
how can you tell apart ACA from MCA infarct
ACA: LE> UE affected
MCA: face/UE> LE affected.
77
pronator drift is sensitive for
pyramidal/corticospinal tract lesion
78
Neuroleptic Malignant syndrome
- fever
- rigidity
- autonomic dysfunction
- mental status change
79
Lewy Body Dementia
cognitive disturbance
Parkinsonism
visual hallucination
80
Multiple Systems Atrophy (shy drager syndrome)
Parkinsonism, orthostatic hypotension, autonomic dysfunction
81
corneal vesicles and dendritic ulcers
HSV keratitis
82
how to manage sunconjunctival hemorrhage?
- just observe for 48 hr, it should self resolve
| usually benign and due to simple trauma
83
how to manage conjunctivitis?
simple viral- use cold compress
| bacterial superinfection- give antibiotics, this will be more purulent
84
"curtain coming down over my eye" with preceding floaters
retinal detachment will show gray retina with tears
85
closed angle vs open angle glaucoma
closed angle is acutely painful eye, headache, and mid-dilated NR pupil
open angle is slower with a gradual loss of vision, seen in AA esp with diabetes and glaucoma hx.
86
acute angle glaucoma diagnosis
goniometry is ophtho available
| tonometry in emergency
87
sudden loss of vision, floaters, can't visualize fundus, red glow
vitreous hemorrhage most often due to diabetic retinopathy
88
dacrocystitis
infection of lacrimal duct. redness and pain over medial canthal region. purulent discharge sometimes
89
contact lens wearer gets corneal ulceration and injection of sclera, painful.
contact keratitis usually caused by pseudomonas or serratia
90
CMV retinitis vs HIV retinitis vs toxo chorioretinitis
CMV- yellow and fluffy with hemorrhages around vasculature
HIV- cotton wool, without hemorrhage, around vasculature
toxo- not around vasc
91
whats sympathetic ophthalmia
it is the "spared eye injury". when one eye is injured and loses sight the other eye experiences disturbances due to an immune mediated reaction from the exposure of "hidden agents"
92
anterior uveitis
red painful eye, decreased visual acuity, hazy aqueous humor, pupillary constriction
assn with IBD, Sarcoid etc.
93
vertical lines in visual grid test seen as wavy and blurred is found in
macular degeneration
94
sudden painless loss of vision is most likely? treatment?
CRAO
| give ocular massage to dislodge thrombus into a more distant branch of eye, and high flow O2.
95
what does CRVO look like on fundoscopy
blood and thunder
| hemorrhage, dilated tortous veins, cotton wool spots
96
what does the visual fields of macular degeneration look like
central vision lost, with peripheral and navigational vision intact
97
retinal necrosis in HIV+ pt is caused by
HSV
98
what are the fetal hydrantoin features
- caused by use of AEDs in pregnancy
| - midfacial hypoplasia, microcephaly, cleft palate/lip, hirsutism, developmental delay, hirsutism
99
homocystinuria
fair and marfanoid with hyperelasticity, thrombosis is common so watch out for stroke
give B6, folate, and antiplatelet agents
100
heat stroke complications
DIC (bleeding)
rhabdo
ARDS
renal failure
101
cherry red spot seen in blindness?
CRAO
102
how to reverse warfarin
vit K (can take a day)
prothrombin complex
FFP ( not preferred bc it takes time to prepare and infuse)
103
glactosemia
a def in galactose 1P uridyl transferase
| cataracts, vomitting, jaundice, MR etc.
104
how is galactosemia diff from a galactokinase def or a UDP galactose 4 epimerase def
galactokinase- purely cataracts
| UDP galactose 4 epimerase def- all of galactosemia + HYPOTONIA and sensorineural DEAFNESS
105
most common cause of spontaneous lobar hemorrhage in >60 yo
amyloid angiopathy, causes weakening of the vessels make a rupture and bleed out more likely. Esp common in alzheimers
106
CONUS vs CAUDA
CONUS- peri anal numbness, hyper-reflexia, early onset incontinence
CAUDA- saddle anesthesia, hyporeflexia , late onset incontinence
107
how to differentiate vascular dementia and alzheimer's
alzheimer's has early onset memory loss, but vasc has early onset executive function losses.
108
commando crawl baby with equinovarus deformity of lower extremities has what?
CP
109
shy drager syndrome
parkisonism + autonomic instability (post hypo, ED) + neuro signs
110
Myotonic Dystrophy genetics
AD
111
Myotonic Dystrophy features
```
myotonia (slow to release grip)
dysphagia
weak face
catarcts
frontal balding
small testis
cardiac conduction
```
112
glucocorticoid induced myopathy has what lab findings?
normal ESR and CK
113
carotid endartectomy indication
>70% stenosis with symptoms
114
NPH caused by ?
decreased CSF absorption
