Neuropharm 1b: Amine neurotransmitters Flashcards
Amine neurotransmitters
what are the 3 amine neurotransmitters?
- noradrenaline
- dopamine
- serotonin
amine neurotransmitters
what is the amine neurotransmitter Noradrenaline associated with?
think hurting someone, sleep, how you feel, sex, and amount of volume of blood in blood vessels
- pain
- sedation
- mood
- arousal
- blood pressure
amine neurotransmitters
what is dopamine as a neurotransmitter associated with
think regulation of movement, how someone acts, and molecules in the body like hormones
- motor control
- behaviour
- endocrine control
amine neurotransmitters
what is serotonin (5-HT) as a neurotransmitter associated with?
think seeing things that arent actually there, how people act, sedation, how you feel, eating, neuronal transmission
- hallucinations
- behaviour
- sleep
- mood
- feeding
- sensory transmission (eg: pain)
Synthesis of dopamine, noradrenaline and adrenaline
outline how dopamine, noradrenaline and adrenaline are synthesised
tryrosine -> DOPA (Via tryrosine hydroxylase) -> Dopamine (via Aromatic Amino acid decarboxylase) -> Noradrenaline (via Dopamine B-hydroxylase) -> Adrenaline (via phenylethaoamine N-methyltransferase)
Synthesis of dopamine, noradrenaline and adrenaline
what is serotonin (5-HT) synthesised from?
synthesised from tryptophan
monoamine uptake
what uptake transporter proteins up take noradrenaline, dopamine and serotonin?
NA: NET
Dopamine: DAT
Serotonin: SERT
monoamine uptake
via what transporter protein does non neuronal uptake occur for NA, Dopamine and 5-HT
via ENT (extra-neuronal transporter)
monoamine metabolism
what enzymes metabolise NA, Dopamine and 5-HT
NA: MAO-A
Dopamine: MAO-A and MAO-B
serotonin (5-HT): MAO-A
Dopamine receptors
what type of receptors are all dopamine receptors?
GPCRs
dopamines receptors
what G protein is D1 and D5 receptors associated with, what does this mean they do, what is the most common Dopamine receptor and what is its main role?
think cAMP for the second part
- Gs coupled
- means they increase cAMP
- D1 has highest expression
- main role is Post synaptic inhibition
dopamine receptors
what G protein is D2, D3 and D4 receptors coupled with, what does this mean they do, what type of inhibition can they perform and what do they regulate?
for second part think cAMP and also think ions as there are 2 things they do
for third part think neurones
for last part think hormones
- Gi/Go coupled
- so decrease cAMP and regulate ion channels
- receptors can be both pre and post synapitc inhibition
- these receptors regulate hormone release
dopamine receptors
what 3 things are both D1 and D2 receptos involved in and give an example of drugs that work at these receptors and their effect
for first part, think regulation of movement and muscle stiffness
for second part, think how someone acts and drugs from breaking bad making someone feel really good
for third part, think hormones and hormones that make you tired to do with breasts
Involved in:
- motor control: dopamine receptor antagonists can cause catalepsy
- behavioural effects: amphetamine and cocaine cause euphoria
- endocrine control: dopamine receptor antagonists can increase prolactin secretion and cause breast development
dopamine receptors
what are dopamine receptor antagonists at D2 receptors used for?
think out of touch with reality
used as anti-psychotics
serotonin receptors
what type of receptors are serotonin receptors apart from 5HT-3 and what type of receptor is this
Serotonin receptors are all GPCRs apart form 5HT-3 which is an ion channel receptor
