Neurophysiology, Plexopathy, Neuropathy Flashcards Preview

Dr. Cheng neuro review Qs > Neurophysiology, Plexopathy, Neuropathy > Flashcards

Flashcards in Neurophysiology, Plexopathy, Neuropathy Deck (24)
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1

For giant axonal neuropathy, describe the following: 

1. inheritance pattern

2. disease mechanism

3. presentation

4. pathology seen on nerve analysis

5. mutation of what gene?

6. prognosis

1. AD

2. disease that affects the intermediate filaments of both CNS and PNS

3. sensory motor axonal neuropathy, corticospinal tract involvement with UMN signs, optic atrophy/vision loss, walking on inner edge of feet, tightly curled hair

4. large focal axonal swelling that contain tightly packed disorganized neurofilaments

5. mutation in GAN gene

6. progressive, death occurs by adolescence

2

What is Refsum's disease? Describe it's inheritance pattern, symptoms (8), and treatment?

AD perioxisomal disorder due to defect in enzyme involved in fatty metabolism --> leads to accumulation of phytanic acid

sx: retinitis pigmentosa, cardiomyopathy, skin changes, large fiber sensorimotor neuropathy, hearing loss, anosmia, ataxia, cerebellar signs

txt: reduce dietary intake of phytanic acid

3

Draw the brachial plexus

4

Describe for each reflex which spinal nerve roots are involved

Reflex - Main Spinal Nerve Roots Involved

Biceps - C5, C6

Brachioradialis - C5, C6

Triceps - C6, C7, C8

Patellar - L2, L3, L4

Achilles Tendon - S1

5

Localize

6

Localize

7

Localize

8

Localize

9

Localize

10

Localize

11

Localize

12

Localize

13

Localize

14

Localize

15

Localize

16

Localize

17

Describe the neoplasm and presentations associated with the following anti-bodies: 

(1) anti-hu

(2) anti-voltage-gated calcium channel

(3) anti-Yo

(4) Anti-Ri

(5) anti-MAG

(1) Anti-Hu - peripheral neuropathy or other neurological manifestations; SCLC

(2) anti-voltage-gated Ca channel - LEMS; SCLC

(3) anti-Yo - cerebellar degeneration; ovarian carcinoma

(4) anti-Ri - opsoclonus-myoclonus +/- ataxia; lung or breast cancer

(5) anti-MAG - demyelinating neuropathy; MGUS

18

What is multifocal motor neuropathy? 

Presentation? (2)

CSF analysis?

antibody associated with this disease? 

results of NCS? 

treatment? 

-purely motor demyelinating neuropathy

-presents with asymmetric weakness from involvement of individual peripheral nerves, hypo or areflexia in the affected nerves.  No sensory symptoms. 

-CSF will have normal protein levels

-associated with Anti-GM1 antibodies

-NCS will show conduction block.  sensory NCS will be normal

-txt: poor response to steroids and PLEX. txt with IVIg

19

Function of tibialis anterior?

ankle dorsiflexion

20

Function of peroneus longus?

ankle eversion

21

Function of tibialis posterior?

anke inversion

22

23

Function of gastrocnemius?

ankle plantarflexion

24

Function of gluteus medius?

hip abduction